Avorelin

Avorelin is a new superagonist of natural LH-RH.Avorelin was formulated in high mol. weight poly(lactic-co-glycolic acid) to afford protracted and continuous release of the peptide from s.c. implants.Two different formulations (10 and 15 mg) were tested first in dogs and then in men during a clin. phase II trial.Chem. castration was maintained for at least 6 mo in dogs with both formulations.A similar duration of activity (approx. 6 mo) was observed in men.