[99mTc]Tc-compound 3 (Egyptian Atomic Energy Authority)([99mTc]Tc-compound 3 (Egyptian Atomic Energy Authority))

概要

基本信息

药物类型

小分子化药、治疗用放射药物

别名-

靶点-

作用方式-

作用机制-

治疗领域

肿瘤

在研适应症

肿瘤

非在研适应症-

原研机构

Egyptian Atomic Energy Authority

在研机构

Egyptian Atomic Energy Authority

非在研机构-

权益机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 [99mTc]Tc-compound 3 (Egyptian Atomic Energy Authority) 相关的临床结果

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100 项与 [99mTc]Tc-compound 3 (Egyptian Atomic Energy Authority) 相关的转化医学

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100 项与 [99mTc]Tc-compound 3 (Egyptian Atomic Energy Authority) 相关的专利（医药）

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1

项与 [99mTc]Tc-compound 3 (Egyptian Atomic Energy Authority) 相关的文献（医药）

2022-08-01·Bioorganic Chemistry2区 · 化学

Conventional and microwave-assisted synthesis, anticancer evaluation, 99mTc-coupling and In-vivo study of some novel pyrazolone derivatives

2区 · 化学

Article

作者: Sayed, Galal H ; Selim, Adli A ; Essa, Basma M ; Anwer, Kurls E

New pyrazolone derivatives were successfully synthesized by both microwave-assisted and conventional techniques. Compound 3 (3-(3-Methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)-3-oxopropanehydrazide) displayed remarkable anti-cancer activity (IC₅₀ obtained at 8.71 and 10.63 µM for HCT-116 and MCF-7, respectively. Moreover, biodistribution study using radiolabeling approach revealed a remarked uptake of [^99mTc]Tc-compound 3 complex into tumour induced in mice. The biodistribution showed high accumulation in tumour tissues with T/NT of 6.92 after 60 min post injection. As a result of these promising data, the newly synthesized compounds especially compound 3 affords a potential radio-carrier that could be used as a tumour marker and can be used for cancer therapy after further preclinical studies.

100 项与 [99mTc]Tc-compound 3 (Egyptian Atomic Energy Authority) 相关的药物交易

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