Gamma-PN3(Gamma-PN3) - 在研适应症：肺炎球菌感染，肺炎球菌性肺炎_专利_临床

概要

基本信息

药物类型

灭活疫苗、预防性疫苗

别名-

靶点-

作用机制

免疫刺激剂

治疗领域

感染呼吸系统疾病

在研适应症

肺炎球菌感染肺炎球菌性肺炎

非在研适应症-

原研机构

GPN Vaccines Ltd.

在研机构

GPN Vaccines Ltd.

非在研机构-

最高研发阶段临床1/2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

3

项与 Gamma-PN3 相关的临床试验

NCT06562790 / Recruiting临床1期

A Phase 1, Randomised, Active-controlled, Blinded, Dose-ranging Study of the Safety, Tolerability, and Immunogenicity of an Inactivated Whole-cell Pneumococcal Vaccine (Gamma-PN3) in Elderly Participants

Phase 1 double- blind randomised active comparator dose escalating study of Gamma PN3 in the elderly

开始日期2024-08-26

申办/合作机构

GPN Vaccines Ltd.

NCT05982314 / Recruiting临床1/2期

A Safety and Immunogenicity Extension Study of GPNV-001

A 6 and 12 month safety and immunogenicity study of participants in study GPNV-001, a novel whole-cell pneumococcal vaccine.

开始日期2023-07-17

申办/合作机构

GPN Vaccines Ltd.

NCT05667740 / Completed临床1期

A Phase 1, Randomised, Placebo-controlled, Double-blind, Sequential Ascending-dose Study to Evaluate the Safety, Tolerability, and Immunogenicity of an Inactivated Whole-cell Pneumococcal Vaccine (Gamma-PN3) in Healthy Adults

This is a randomised placebo-controlled first-in-man dose-ranging study to determine safety and markers of efficacy.

开始日期2023-01-16

申办/合作机构

GPN Vaccines Ltd.

100 项与 Gamma-PN3 相关的临床结果

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100 项与 Gamma-PN3 相关的转化医学

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100 项与 Gamma-PN3 相关的专利（医药）

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4

项与 Gamma-PN3 相关的文献（医药）

2017-04-18·Ying yong sheng tai xue bao = The journal of applied ecology

保氮剂对水葫芦堆肥进程及氮素损失的影响.

Article

作者: DU, Yu Long ; Gou, Xiao Lin ; Luo, Xue Mei ; Tu, Wei Guo ; Li, Sen ; Wang, Qiong Yao ; Li, Ling ; Fan, Hua

为研究保氮剂对水葫芦堆肥进程及氮素损失的影响,以切碎的水葫芦为原料,以硫酸亚铁、腐植酸钠、过磷酸钙按75∶20∶5质量比配制成保氮剂,进行35 d的好氧堆肥试验.试验设置占堆体总质量0%(对照,CK)、1%(PN1)、2%(PN2)、3%(PN3)的保氮剂4个处理,对堆肥过程中堆体理化性质、氮组分含量、氨挥发及氮素损失率进行监测.结果表明: 堆肥高温期,保氮剂处理的堆温明显高于CK,堆体含水量则在降温期显著低于CK(P＜0.05).堆肥完成后,保氮剂处理的全氮、有机氮含量均显著增加,以PN3处理最高,其全氮、有机氮含量分别比CK高16.3%和13.2%;同时,PN1、PN2、PN3处理的氨挥发总量分别比CK低25.9%、31.5%、42.4%,氮素固定率则分别达31.3%、40.7%、72.2%.表明水葫芦堆肥过程中添加保氮剂可加快启动速度、缩短堆肥时间,并能减少氨挥发、氮素损失.总体上,以PN3处理效果最佳.

2016-06-01·Yonago acta medica

Wnt/Beta-Catenin Signal Inhibitor HC-1 Sensitizes Oral Squamous Cell Carcinoma Cells to 5-Fluorouracil through Reduction of CD44-Positive Population.

Article

作者: Oka, Hiroyuki ; Tsubota, Toshiaki ; Itaba, Noriko ; Morimoto, Minoru ; Ryoke, Kazuo ; Yokogi, Satoshi ; Shiota, Goshi ; Kanki, Keita ; Azumi, Junya

BACKGROUNDOral squamous cell carcinoma is a prevalent and frequently lethal malignancy worldwide. Existence of treatment-resistant cancer stem cells is considered to be associated with tumor formation, recurrence and metastasis. Wnt/beta-catenin signal is one of the crucial signaling pathways for cancer stem cells. Wnt/beta-catenin signal inhibitor may reduce the population of cancer stem cells and improve therapeutic effects on the cancers.METHODSThe effects of three derivatives of Wnt/beta-catenin signal inhibitors, HC-1, IC-2 and PN3-13, which we recently developed, on oral squamous cell carcinoma cell line HSC2, were examined by luciferase reporter assay, WST assay, cell sorting assay and apoptosis assay.RESULTSThe reporter assay showed that these small molecule compounds reduced Wnt/beta-catenin transcriptional activity in HSC2 cells. Of these compounds, IC-2 and PN3-13 inhibited cell viability in a dose-dependent manner, whereas HC-1 did not at even higher concentrations. Notably, however, the cell-sorting assay revealed that HC-1 significantly reduces the CD44-positive population of oral squamous cell carcinoma cells, compared to other compounds without affecting cell viability. In addition, HC-1 increases the cytotoxicity of HSC2 cells to 5-fluorouracil. The combination treatment of HC-1 with 5-fluorouracil significantly increased the apoptotic cells whereas treatment by either compound did not.CONCLUSIONThese data suggest that HC-1 is an effective compound to target cancer stem cells, and the combination treatment of HC-1 and 5-fluorouracil can stimulate the tumor suppressive effect on oral squamous cell carcinoma cells.

Nutrients2区 · 医学

Bamboo Stems (Phyllostachys nigra variety henosis) Containing Polyphenol Mixtures Activate Nrf2 and Attenuate Phenylhydrazine-Induced Oxidative Stress and Liver Injury

2区 · 医学

ArticleOA

作者: Cho, Sam Seok ; Yang, Ji Hye ; Shin, Hyun-Jae ; Kim, Jae Hoon ; Ki, Sung Hwan ; Na, Chang-Su ; Choi, Moon-Hee ; Cho, Il Je ; Ku, Sae Kwang

This study was designed to investigate the hepatoprotective effect of bamboo stems using in vitro and in vivo experimental liver damage models. Ethyl acetate fraction of 80% ethanol extract of Phyllostachys nigra stem (PN3) containing polyphenols had a higher NQO1-ARE reporter gene activity as monitored by the activity of the NF-E2-related factor (Nrf2) antioxidant pathway in cells in comparison to extracts from other species and under other conditions. The Nrf2 was translocated from the cytosol to the nucleus in response to PN3, followed by induction of the Nrf2 target gene expression, including HO-1, GCL, and NQO-1 in HepG2 cells. Phosphorylation of Nrf2 in HepG2 cells was enhanced in PN3, which was mediated by PKCδ, ERK, and p38 MAPK. Consequently, PN3 inhibited arachidonic acid (AA) + iron-induced reactive oxygen species generation and glutathione depletion, and, thus, highlighted their role in cytotoxicity. Treatment with major polyphenols of PN3, including catechin, chlorogenic acid, caffeic acid, and p-coumaric acid, also improved AA + iron-mediated oxidative stress and, thus, improved cell viability. Treatment with phenylhydrazine in mice, i.e., the iron overload liver injury model, increased plasma alanine aminotransferase and aspartate aminotransferase levels and changed histological features in mice—a response that was almost completely blocked by PN3 administration. Moreover, PN3 extract mitigated phenylhydrazine-induced oxidative stress and inflammatory responses. Conclusively, PN3 can exert a hepatoprotective effect against iron overload-induced acute liver damage due to its antioxidant properties.

100 项与 Gamma-PN3 相关的药物交易

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