INP-102(INP-102) - 药物靶点：INSR_在研适应症：阿尔茨海默症_专利_临床

概要

基本信息

药物类型

合成多肽

别名

Insulin、POD insulin

靶点

INSR

作用机制

INSR激动剂(胰岛素受体激动剂)

治疗领域

神经系统疾病

在研适应症

阿尔茨海默症

非在研适应症-

原研机构

Ipi Legacy Liquidation Co.

在研机构

Ipi Legacy Liquidation Co.

非在研机构-

最高研发阶段临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

27

项与 INP-102 相关的临床试验

NCT05006599 / Not yet recruiting临床2期IIT

Study of Nasal Insulin to Fight Forgetfulness (SNIFF) - 3-Week Aptar CPS Device

The SNIFF 3-Week Aptar Device study will involve using a device to administer insulin or placebo through each participant's nose or intra-nasally. Insulin is a hormone that is produced in the body. It works by lowering levels of glucose (sugar) in the blood. This study is measuring how much insulin the device delivers. In addition, this study will look at the effects of insulin or placebo administered intra-nasally using an intranasal delivery device on memory, blood, and cerebrospinal fluid (CSF).

开始日期2025-05-01

申办/合作机构

Wake Forest School of Medicine

NCT06592261 / Recruiting临床1期IIT

Human Models of Selective Insulin Resistance: Graded Insulin Suppression Test (GIST) Pilot & Feasibility Study

The goal of this study is to learn about how the hormone insulin controls blood sugar in a variety of people. The main question it aims to answer is about how much insulin the body actually needs to maintain a normal blood sugar level. Participants will be asked to come in for a one-day study visit in which they will undergo a "graded insulin suppression test" ("GIST"). The GIST involves intravenous (into the vein) infusions of octreotide, a medication that turns off the body's own production of insulin, as well as replacement insulin at two different levels (low and high) and glucose (sugar). The study investigators will check blood sugar levels every few minutes during the procedure to determine the effect of the two different insulin levels. This study will evaluate the GIST in both healthy volunteers and those at higher risk for type 2 diabetes.

开始日期2024-09-16

申办/合作机构

Columbia University

[+1]

IRCT20240606062025N1 / Recruiting临床3期IIT

Investigating the effect of administration of insulin glucose solution in the preanhepatic phase on the heart outcome of patients undergoing orthotopic liver transplantation

开始日期2024-06-19

申办/合作机构

Shahid Beheshti University of Medical Sciences

100 项与 INP-102 相关的临床结果

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100 项与 INP-102 相关的转化医学

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100 项与 INP-102 相关的专利（医药）

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5

项与 INP-102 相关的文献（医药）

2024-08-01·Journal of Hazardous Materials

Peroxidase in plant defense: Novel insights for cadmium accumulation in rice (Oryza sativa L.)

Article

作者: Wu, Yingjie ; Liu, Jiahui ; Tao, Qi ; Lv, Yunxuan ; Wang, Changquan ; Li, Bing ; Li, Meng

Phenylpropanoid biosynthesis plays crucial roles in the adaptation to cadmium (Cd) stress. Nevertheless, few reports have dabbled in physiological mechanisms of such super pathway regulating Cd accumulation in plants. Herein, by integrating transcriptomic, histological and molecular biology approaches, the present study dedicated to clarify molecular mechanism on how rice adapt to Cd stress via phenylpropanoid biosynthesis. Our analysis identified that the enhancement of phenylpropanoid biosynthesis was as a key response to Cd stress. Intriguingly, POD occupied a significant part in this process, with the number of POD related genes accounted for 26/29 of all upregulated genes in phenylpropanoid biosynthesis. We further used SHAM (salicylhydroxamic acid, the POD inhibitor) to validate that POD exhibited a negative correlation with the Cd accumulation in rice tissues, and proposed two intrinsic molecular mechanisms on POD in contributing to Cd detoxification. One strategy was that POD promoted the formation of lignin and CSs both in endodermis and exodermis for intercepting Cd influx. In detail, inhibited POD induced by external addition of SHAM decreased the content of lignin by 50.98-66.65 % and delayed percentage of the D_TIP-CS to root length by 39.17-104.51 %. The other strategy was expression of transporter genes involved in Cd uptake, including OsIRT1, OsIRT2, OsZIP1 and OsZIP, negatively regulated by POD. In a word, our findings firstly draws a direct link between POD activity and the Cd accumulation, which is imperative for the breeding of rice with low-Cd-accumulating capacity in the future.

2019-05-01·Journal of Chromatography B3区 · 医学

Purification of peroxidase enzyme from radish species in fast and high yield with affinity chromatography technique

3区 · 医学

Article

作者: Erel, Deniz ; Sengül, Mehmet Emin ; Almaz, Zuleyha ; Oztekin, Aykut ; Gerni, Serpil ; Kocak, Seyma Mehtap ; Ozdemir, Hasan

In this study, an effective single step affinity method is presented for purifying plant peroxidase (POD) enzymes from radish species. This method make possible to purify the enzymes in high yield and purity. Briefly, 10 different 4-amino benzohydrazide derivatives were synthesized and identified as new competitive POD inhibitors. Then, these derivatives were coupled to Sepharose 4B-L-Tyrosine support matrix by diazotization to form the affinity gels. Purification factors were recorded as 54.8% yield - 665-fold, 33.8% yield - 613-fold, 22.7% yield - 595-fold, 34.4% yield - 781-fold, 40.9% yield - 282-fold for turnip (T-POD), black radish (BR-POD), daikon (D-POD), sweet radish (SR-POD) and kohlrabi radish, (KR-POD), respectively. It has also been shown that the affinity gels, which prepared using the 4-amino 3-bromo benzohydrazide and 4-amino 2-nitro benzohydrazide molecules, capable to purify all radish species POD enzymes in high purity and yield.

2017-11-01·Plant Physiology and Biochemistry2区 · 生物学

Overexpressing sweetpotato peroxidase gene swpa4 affects nitric oxide production by activating the expression of reactive oxygen species- and nitric oxide-related genes in tobacco

2区 · 生物学

Article

作者: Yun, Byung-Wook ; Kim, Yun-Hee ; Kwak, Sang-Soo ; Park, Sung Chul

Reactive oxygen species (ROS) and nitric oxide (NO) are key signaling molecules involved in various developmental and stress responses in plants. NO and ROS production, which is triggered by various stimuli, activates downstream signaling pathways to help plants cope with abiotic and biotic stresses. Recent evidence suggests that the interplay between NO and ROS signaling plays a critical role in regulating stress responses. However, the underlying molecular mechanism remains poorly understood. We previously reported that transgenic tobacco overexpressing the swpa4 peroxidase (POD) gene from sweetpotato exhibits increased tolerance to stress. Overexpression of swpa4 also induces the generation of H₂O₂ and activates the expression of various extracellular acidic pathogenesis-related (PR) genes. Here, we show that swpa4 positively regulates the expression of ROS- and NO-related genes in transgenic tobacco plants. Plants expressing swpa4 exhibited increased expression of ROS-related genes and increased ROS-related enzyme activity under normal conditions and H₂O₂ treatment, whereas the expression of NO associated 1 (NOA1) only increased under normal conditions. Moreover, plants overexpressing swpa4 showed increased NO levels under normal conditions and after treatment with the NO donor sodium nitroprusside (SNP). Interestingly, treatment with a POD inhibitor dramatically reduced NO levels in swpa4 transgenic plants. These findings suggest that swpa4 regulates H₂O₂ and NO homeostasis in plants under stress conditions, thereby establishing a possible molecular link between the NO and ROS signaling pathways.

100 项与 INP-102 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
阿尔茨海默症	临床3期	-	Ipi Legacy Liquidation Co.	-

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


998-P (ADA2024)	N/A	-	-	Computerized Insulin Dose Adjustment Algorithms (CIDAAs) (Free Style Libre Pro)	膚繭醖鬱壓窪壓獵網蓋(選鹽積淵觸構獵構鹽築) = 窪蓋夢遞觸選衊積齋簾選窪鬱獵艱淵鹹鹽鹹糧 (築網窪顧簾窪艱壓醖壓, 2.4)	积极	2024-06-14
				Computerized Insulin Dose Adjustment Algorithms (CIDAAs) (Dexcom reader)	膚繭醖鬱壓窪壓獵網蓋(選鹽積淵觸構獵構鹽築) = 膚繭顧窪鑰願醖膚製衊選窪鬱獵艱淵鹹鹽鹹糧 (築網窪顧簾窪艱壓醖壓, 1.9)
ADA2024	N/A	-	-	Omnipod 5 Automated Insulin Delivery (AID) System	艱觸構窪積遞選獵積選(衊窪糧餘網窪膚蓋鹹夢) = 鹹範構獵蓋遞窪襯選築夢構鹹遞觸願製選醖觸 (鏇鬱憲齋範鹹積壓網選 ) 更多	-	2024-06-14
Omnipod 5 (EASD2023)	N/A	1型糖尿病	-	Omnipod 5 Automated Insulin Delivery (AID) system	(獵築艱襯繭衊艱構蓋淵) = 鏇獵網糧窪憲觸衊壓襯齋餘夢醖膚餘觸鑰齋窪 (鏇範願製淵襯夢鏇範構 ) 更多	积极	2023-10-05
EASD2023	N/A	2型糖尿病	-	Semaglutide	(夢積網鹽築鏇襯觸窪廠) = 製鹹蓋選鑰糧遞鏇窪蓋簾構積憲蓋齋壓觸糧淵 (繭鹽繭鏇憲簾壓選憲鬱 )	-	2023-10-05
				Insulin	蓋夢鬱觸齋廠憲範選膚(鹽壓衊觸鑰憲鬱醖淵餘) = 鑰觸壓遞夢構齋鹹衊鹹觸廠願積製醖鬱壓夢淵 (觸鹹構齋齋衊窪簾鬱膚 ) 更多
EASD2022	N/A	2型糖尿病	814	iGlarLixi (insulin glargine 100 U/mL + lixisenatide)	夢醖鬱網鏇鬱築廠壓糧(衊廠廠簾獵餘網積鹽願) = 廠築顧獵廠窪遞壓鏇蓋淵襯齋膚鏇醖艱簾顧鏇 (憲願餘願襯鏇鑰觸鏇鑰, <0.025)	积极	2022-09-20
				Basal insulin (BI) + Rapid-acting insulin (RAI)	夢醖鬱網鏇鬱築廠壓糧(衊廠廠簾獵餘網積鹽願) = 糧製網憲鏇獵構窪繭蓋淵襯齋膚鏇醖艱簾顧鏇 (憲願餘願襯鏇鑰觸鏇鑰, <0.025)
NCT01963728 (CTgov)	临床4期	糖尿病	2	Insulin, Isophane (Insulin Isophane)	簾選製願艱願鬱鹹選鑰(壓鏇鏇壓製遞製壓構鹽) = 遞製構獵夢獵廠淵鏇廠簾夢壓顧艱鏇襯餘選鏇 (鏇範襯餘壓築廠壓範艱, 獵簾鹽餘鬱蓋觸構夢醖 ~ 積願願網窪願糧觸壓鑰) 更多	-	2022-01-12
				Insulin Glargine (Insulin Glargine)	簾選製願艱願鬱鹹選鑰(壓鏇鏇壓製遞製壓構鹽) = 窪簾窪淵窪觸齋觸鹹獵簾夢壓顧艱鏇襯餘選鏇 (鏇範襯餘壓築廠壓範艱, 簾膚齋衊築鹽觸簾網選 ~ 積衊觸範積醖獵膚醖鹹) 更多
EASD2021	N/A	1型糖尿病	-	Omnipod DASH ® Insulin Management System	齋衊餘衊遞鑰蓋餘鏇繭(鬱積簾築鬱衊憲獵膚鬱) = 齋積繭簾製鹹築膚窪範衊願範餘窪鑰鹹顧蓋鹽 (餘構醖鬱艱繭窪鹽鑰膚 ) 更多	-	2021-09-30
				Omnipod DASH ® Insulin Management System	齋衊餘衊遞鑰蓋餘鏇繭(鬱積簾築鬱衊憲獵膚鬱) = 鏇願積鬱衊鏇廠遞窪襯衊願範餘窪鑰鹹顧蓋鹽 (餘構醖鬱艱繭窪鹽鑰膚 ) 更多
EASD2021	N/A	1型糖尿病	-	Omnipod DASH® Insulin Management System	鏇衊膚餘壓餘襯膚淵選(積鹽願憲夢夢窪範夢製) = 選壓糧衊顧築鏇蓋遞壓獵廠齋齋膚構遞獵築鹹 (齋衊餘鬱壓製膚遞鏇遞, 2.7) 更多	-	2021-09-30
Accu-Chek DiaPort (EASD2021)	N/A	糖尿病	49	Continuous intraperitoneal insulin infusion (CIPII) with Accu-Chek DiaPort system	(醖襯膚衊願製鑰築鏇憲) = 憲遞繭獵簾構觸壓膚觸鑰遞鬱範簾餘鏇製壓鏇 (鹽鑰齋襯淵淵範獵築醖 )	积极	2021-09-29
EASD2020	N/A	2型糖尿病	-	Basal-bolus insulin	(獵蓋構壓鏇鹽糧鹹襯簾) = 夢選網憲顧構範衊鏇繭餘築膚鑰鹹製齋夢鏇繭 (構蓋顧廠獵範構齋淵窪, 4.3) 更多	积极	2020-09-22
				Premixed insulin	(獵蓋構壓鏇鹽糧鹹襯簾) = 襯簾範鹹顧壓蓋網鹹遞餘築膚鑰鹹製齋夢鏇繭 (構蓋顧廠獵範構齋淵窪, 4.2) 更多