更新于：2024-11-21

Ascorbic Acid/L-Cysteine

抗坏血酸/L-半胱氨酸

更新于：2024-11-21

概要

概要

基本信息

药物类型

小分子化药

别名

アスコルビン酸/L-システイン、维生素C/L-半胱氨酸、Crystfan

+ [1]

靶点-

作用机制-

治疗领域

内分泌与代谢疾病

在研适应症

维生素缺乏

非在研适应症-

原研机构

Nisshin Co., Ltd.

在研机构

Nisshin Co., Ltd.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (1990-05-15),

维生素缺乏

最高研发阶段(中国)-

特殊审评-

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结构

分子式C6H8O6

InChIKeyCIWBSHSKHKDKBQ-JLAZNSOCSA-N

CAS号50-81-7

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关联

100 项与抗坏血酸/L-半胱氨酸相关的临床结果

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100 项与抗坏血酸/L-半胱氨酸相关的转化医学

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100 项与抗坏血酸/L-半胱氨酸相关的专利（医药）

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项与抗坏血酸/L-半胱氨酸相关的文献（医药）

2021-01-15·Organic Letters1区 · 化学

Convergent Total Synthesis of the Siderophore Piscibactin as Its Ga³⁺ Complex

1区 · 化学

Article

作者: Rodríguez, Jaime ; Jiménez, Carlos ; Segade, Yuri ; de la Fuente, M. Carmen ; Valderrama, Katherine

The siderophore piscibactin is a key virulence factor involved in the iron uptake of pathogenic bacteria Photobacterium damselae subsp. piscicida and Vibrio anguillarum, responsible for the fish diseases photobacterioisis (pasteurellosis) and vibriosis, respectively. A convergent total synthesis of its Ga³⁺ complex using l-/d-cysteine as chiral agents and Meldrum's acid is described. A Staudinger reduction/Aza-Wittig process in the synthesis of the acid-sensitive β-hydroxy-2,4-disubstituted thiazoline moiety and the convenient protecting groups was a key step in this synthesis.

2019-05-06·Inorganic Chemistry2区 · 化学

Chiroptical Activity of Type II Core/Shell Cu₂S/CdSe Nanocrystals

2区 · 化学

Article

作者: Jiang, Shuang ; Ma, Xiaoyuan ; Li, Bin ; Zhou, Minghao ; Zhang, Tianyong ; Wang, Jingchao ; Shao, Xiao

Ligand-induced chirality in core/shell nanocrystals (NCs) has attracted extensive attention because of many valuable potential applications. However, the cause of chirality especially in semiconductor nanomaterials is still under debate despite the creation of chiral type I core/shell structures. Herein, we synthesized a kind of new Cu₂S/CdSe core/shell nanostructure to study the underlying reason. Four samples of Cu₂S/CdSe were synthesized utilizing successive ion layer adsorption and reaction to vary the thickness of the CdSe shell upon a Cu₂S core with 5 nm diameter. The chirality of type II Cu₂S/CdSe NCs is imparted by l-/d-cysteine and penicillamine, which could be modulated with an increasing thickness of the CdSe shell. To the best of our knowledge, this is the first report of chiral type II core/shell semiconductor NCs. The hybridization theory can explain the variation trend of g factors with every increase in shell thickness from four monolayers (4 ML) to 7 ML. The results indicate that the chiroptical activity of semiconductor NCs is mainly due to hybridization between the holes in the valence band of NCs and the highest occupied molecular orbitals of the chiral ligands. In addition, Cu₂S/CdSe NCs show a better chiroptical intensity in comparison with the type I structure according to previous work. The first design of chiral type II Cu₂S/CdSe core/shell NCs and a detailed investigation of chiral variation trend help to give a better understanding of the chiral interaction between ligands and core/shell semiconductor nanostructures.

2019-05-01·Biochemical and Biophysical Research Communications3区 · 生物学

Steric configuration-enabled selective antimicrobial activity of chiral cysteine

3区 · 生物学

Article

作者: Yan, Wenjing ; Wang, Hongxia ; Zhang, Jianhao ; Qian, Jing ; Gu, Jiayi

Antibiotics abusing caused multi-drug resistant bacteria was an urgent need to develop effective alternatives to antibiotics. L-Cysteine is an amino acid commonly found in organisms, which is usually used as food additive and detoxication, while the antibacterial activity of L-Cysteine against pathogenic bacteria is rarely reported. Here, we demonstrated the broad-spectrum and selected antibacterial properties of D-/L-Cysteine, for the first time, D-Cysteine (D-Cys) and L-Cysteine (L-Cys) exhibited distinct antibacterial activity based on different bacteria (Escherichia coli, Staphylococcus aureus, Listeria monocytogenes and Salmonella enteritis). Among the four bacteria, L-Cys exhibited preferred antibacterial activity against S. aureus, while D-Cys showed stronger antibacterial activity against other three bacteria compared with L-Cys. Through analyzing cell structure of E. coli, it was demonstrated that D/L-Cys could destroy the integrity of E. coli cell membrane, which further resulted in the leakage of cell contents and cell death. This work has a potential value for the development of chiral bacteriostatic materials.

100 项与抗坏血酸/L-半胱氨酸相关的药物交易

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