DA-023(DA-023) - 药物靶点：EAAT2_在研适应症：中枢神经系统疾病_专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点

EAAT2

作用机制

EAAT2调节剂(solute carrier family 1 member 2 modulators)

治疗领域

神经系统疾病

在研适应症

中枢神经系统疾病

非在研适应症-

原研机构

Drexel University College of Medicine

在研机构

Drexel University College of Medicine

非在研机构-

最高研发阶段药物发现

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构

分子式C20H25N7

InChIKeyVGNIHZIDQKBDHQ-UHFFFAOYSA-N

CAS号2585643-97-4

关联

100 项与 DA-023 相关的临床结果

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100 项与 DA-023 相关的转化医学

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100 项与 DA-023 相关的专利（医药）

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2

项与 DA-023 相关的文献（医药）

1998-01-01·Biological and Pharmaceutical Bulletin4区 · 医学

Potent Retinoid Synergists with a Diphenylamine Skeleton.

4区 · 医学

Article

作者: Tsuji, Motonori ; Fukasawa, Hiroshi ; Kawachi, Emiko ; Shudo, Koichi ; Ohta, Kiminori ; Hashimoto, Yuichi ; Kagechika, Hiroyuki

4-[N-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)amino]benzoic acid (5) exhibited weak retinoidal and retinoid synergistic activities in HL-60 cell differentiation assay. N-Alkylation of 5 caused decrease or loss of differentiation-inducing activity, but enhanced the synergistic activity with a synthetic retinoid Am80 (2), as reflected in the potent synergistic EC50 (SEC50) values of DA023 (11, 1.6 x 10(-10) M) and DA113 (14, 1.4 x 10(-10) M) in the presence of 1.0 x 10(-10) M Am80 (2).

1983-07-01·The Journal of General Psychology4区 · 心理学

Pattern Memory and Resistance to Extinction in Double Alternating Reinforcement

4区 · 心理学

Article

作者: Ishida, Masato

Interval between acquisition and extinction (A-E interval) was varied in order to investigate effects of regularly alternated partial reinforcement on resistance to extinction and to assess the notion of pattern memory which was suggested on the basis of single alternation study. Random alternation (RA) and double alternation (DA) groups were trained with extensive trials and then extinguished under one-day's (RA1, DA1) or 23-days' (RA23, DA23) A-E interval. RA1 was more resistant to extinction than DA1, but DA23 did not differ from RA23. Moreover, extinction performance of DA schedule was retained well in spite of the extension of A-E interval, unlike that of RA schedule. These extinction results cannot be interpreted consistently even by the N-length variables. The persistence of DA schedule shown in delayed extinction was discussed in terms of the pattern memory assumption.

100 项与 DA-023 相关的药物交易

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