2
项与 Allogeneic umbilical cord-derived human mesenchymal stromal cells(Ottawa Hospital Research Institute) 相关的临床试验Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock: A Multi-Center, Double Blind, Phase II Randomized Controlled Trial
Septic shock is associated with substantial burden in terms of both mortality and morbidity for survivors of this illness. Pre-clinical sepsis studies suggest that mesenchymal stem (stromal) cells (MSCs) modulate inflammation, enhance pathogen clearance and tissue repair and reduce death. Our team has completed a Phase I dose escalation and safety clinical trial that evaluated MSCs in patients with septic shock. The Cellular Immunotherapy for Septic Shock Phase I (CISS) trial established that MSCs appear safe and that a randomized controlled trial (RCT) is feasible. Based on these data, the investigators have planned a phase II RCT (UC-CISS II) at several Canadian academic centres which will evaluate intermediate measures of clinical efficacy (primary outcome), as well as biomarkers, safety, clinical outcome measures, and a health economic analysis (secondary outcomes).
Helping Underdeveloped Lungs With Cells (HULC): Mesenchymal Stromal Cells in Extreme Preterm Infants at Risk of Developing Bronchopulmonary Dysplasia - Phase 1 Study
Bronchopulmonary dysplasia (BPD) is a common and chronic lung disease that occurs in preterm infants following ventilator and oxygen therapy and is associated with long-term health consequences. Preclinical research shows that mesenchymal stromal cells (MSCs) can modify a number of pathophysiological processes that are central to the progression of BPD and thus present as a promising new treatment option. The main purpose of this Phase I study is to evaluate the safety of human umbilical cord tissue-derived MSCs in extremely preterm infants at risk of developing BPD.
100 项与 Allogeneic umbilical cord-derived human mesenchymal stromal cells(Ottawa Hospital Research Institute) 相关的临床结果
100 项与 Allogeneic umbilical cord-derived human mesenchymal stromal cells(Ottawa Hospital Research Institute) 相关的转化医学
100 项与 Allogeneic umbilical cord-derived human mesenchymal stromal cells(Ottawa Hospital Research Institute) 相关的专利(医药)
100 项与 Allogeneic umbilical cord-derived human mesenchymal stromal cells(Ottawa Hospital Research Institute) 相关的药物交易