A Comparative Evaluation of Human Thrombin Versus Bovine Thrombin in Achieving Hemostasis in Patients Undergoing Cardiovascular, Neurologic (Spine) and General Surgery Procedures.

The purpose of this study is to see if Human Thrombin is as effective as Bovine Thrombin in stopping surgical bleeding within 10 minutes of application.

开始日期2004-11-01

申办/合作机构

Ethicon, Inc.

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100 项与 Thrombin, Topical (Human) (Omrix) 相关的临床结果

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100 项与 Thrombin, Topical (Human) (Omrix) 相关的转化医学

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100 项与 Thrombin, Topical (Human) (Omrix) 相关的专利（医药）

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项与 Thrombin, Topical (Human) (Omrix) 相关的文献（医药）

2012-06-01·Clinical and Applied Thrombosis/Hemostasis4区 · 医学

Cross-Reactivity of Various Thrombin Products With Anti-Rabbit Antibodies to Bovine, Human, and Recombinant Thrombin

4区 · 医学

Article

作者: Cunanan, Josephine ; Zhu, He ; Setty, Saayi Krushna Gadham ; Sadeghi, Nasir ; Hoppensteadt, Debra ; Fareed, Jawed

JMI-thrombin is used as topical hemostatic agent. While earlier clinically available JMI were reported to produce immunologic responses upon repeated exposure, the improved JMI, Recothrom?, and Evithrom? are claimed to be less immunogenic. Recothrom, despite its reduced immunogenic nature, upon repeated administration may result in the generation of antibodies (Abs) and that may cross react with bovine and human thrombin. Therefore, groups of rabbits were challenged repeatedly with Recothrom, Evithrom, and JMI over a 9-month period. Pre-immune blood and antiserum were collected from each rabbit on different time point. To determine their relative cross reactivity, JMI, Recothrom, and Evithrom were evaluated by western blotting using the rabbit IgG fractions. The results suggest that anti-Recothrom Abs cross-react with Evithrom and JMI in a time dependent fashion. Anti-JMI Abs did not cross-react with Recothrom, and Evithrom. Also, anti-Evithrom did not show any cross-reactivity with Recothrom and JMI at any time.

2007-10-01·American Journal of Health-System Pharmacy

FDA licenses human thrombin product

作者: Traynor, Kate

FDA in August announced that it had approved the licensing of Evithrom human thrombin as an aid to homeostasis during surgery. According to FDA, Evithrom is the first human thrombin product to be approved in more than 50 years and the only such product currently licensed in the United States.

100 项与 Thrombin, Topical (Human) (Omrix) 相关的药物交易

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