Sania Therapeutics launches to advance novel medicines for neural circuit dysfunction

Sania emerges from stealth mode and presents key proof-of-concept data at ASGCT 2023

Launching core technology platforms which enable the precision delivery of proteins for neuromodulation

Team combines world-leading scientific pioneers with industry drug development expertise

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来源: GlobeNewswire-Health Care

17 May 2023, Sania Therapeutics (the “Company”), focused on developing genetic medicines for neural circuit dysfunction, launches today by unveiling its suite of proprietary patented platforms at the American Society of Gene & Cell Therapy (ASGCT) conference.

Sania’s human-centric approach combines the evolution of adeno-associated viruses (AAV) in human neural circuits, the fundamental components of the nervous system, with tuneable conditionally-activated ion channels. This permits breakthrough efficacy by correcting dysfunctional neural excitation, thereby unlocking a broad range of diseases both within and beyond neurology.

The Company’s foundational technology platforms were first developed at University College London by Sania’s Co-Founders. Today’s launch follows the closing of an oversubscribed Series Seed financing, proceeds of which have been applied to platform development, advancing a lead program in motor disorders, as well as initiating additional undisclosed programs which leverage platform capabilities.

“We formed Sania with a simple yet powerful vision: to be the first in developing medicines that treat disorders of neural circuits selectively. Today we are excited to demonstrate proof-of-principle data and unveil our platforms,” said Andy Murray, Ph.D, CEO & Co-Founder of Sania Therapeutics.

“I'm very excited to be working with the team at Sania and believe their novel approach to neural modulation could lead to real benefits for patients,” added Advisory Board member, Dr. Jane Hughes.

Sania’s approach: human-centric precision delivery of tuneable genetic neuromodulation

Sania is unveiling its core patented technology platforms and proof-of-principle data at ASGCT in presentations on 17 and 18 May. These platforms enable the precision delivery of proteins for neuromodulation to selected individual neural circuits.

Human-centric precision delivery is enabled by Sania’s R-Scan platform, which leverages the combination of microfluidics with a diverse population of human induced pluripotent stem cells to recreate human neural circuits in a dish, enabling the directed evolution of human-centric AAVs. The proof-of-concept data being presented at for R-Scan is generated in fully functional human motor neuron-muscle circuits. R-Scan is complemented by a second platform, Gre-Scan, a novel and proprietary technology for the high throughput screening of gene regulatory elements.

These platforms are combined with Neu-Scan, which facilitates tuneable genetic neuromodulation through the testing and validation of the overexpression of conditionally-activated ion channels. The presented proof-of-concept data demonstrate that the platform has identified ion channels, deliverable by AAV, that enable the treatment of dysfunctional neural excitation.

About Sania Therapeutics

Sania Therapeutics is a ground-breaking biotechnology company pioneering new approaches for the treatment of neural circuit dysfunction. Sania’s approach combines precision delivery of genetic medicines with neuromodulation using a human-centric approach to therapeutic development. Sania is based in London, UK. For more information visit www.saniarx.com.

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