Even Transient Food Allergy in Infancy Impacts Later Lung Function

2023-08-02

临床结果

WEDNESDAY, Aug. 2, 2023 -- Food allergy in infancy, whether it resolves or not, is associated with lung function deficits and asthma at age 6 years, according to a study published online July 25 in The Lancet Child & Adolescent Health.

Rachel L. Peters, Ph.D., from Murdoch Children's Research Institute in Parkville, Australia, and colleagues used data from 5,276 children aged 1 year who attended immunization sessions (Sept. 28, 2007, to Aug. 5, 2011). At 1 year of age, all children completed skin prick testing for four food allergens (egg, peanut, sesame, and either shrimp or cow's milk) and an oral food challenge (egg, peanut, and sesame). The analysis included 3,233 who also completed the health assessment at age 6 years.

The researchers found that food allergy, but not food-sensitized tolerance, at age 1 year was associated with reduced forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) at age 6 years. Transient egg allergy was associated with reduced FEV1 and FVC compared with never having egg allergy, but persistent egg allergy was not. Transient, persistent, and late-onset peanut allergy were associated with reduced FEV1 and FVC. Although some were imprecise, estimates suggested that food-sensitized tolerance and food allergy were associated with reduced forced expiratory flow at 25 percent and 75 percent of the pulmonary volume. There was no association between food allergy phenotypes and FEV1/FVC ratio. There was an association between both food-sensitized tolerance and food allergy at age 1 year with increased asthma risk at age 6 years. Asthma risk was even higher for persistent and late-onset peanut allergy.

"Lung development is related to a child's height and weight, and children with a food allergy can be shorter and lighter compared to their peers without an allergy," Peters said in a statement. "This could explain the link between food allergy and lung function. There are also similar immune responses involved in the development of both food allergy and asthma."

Several authors disclosed financial ties to industry.

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Posted August 2023

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