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ImmunAbs Announces Conclusion of Phase 1 Clinical Trial, Revealing Positive Topline Results

2024-03-11

临床结果临床1期临床2期抗体药物偶联物

SEOUL, South Korea, March 11, 2024 /PRNewswire/ -- ImmunAbs, a leading clinical-stage biotechnology company focused on developing novel antibody therapeutics, today announced the successful completion of the Phase 1 clinical trial for IM-101. IM-101 is a humanized monoclonal antibody targeting complement C5, which plays a pivotal role in complement activation. The complement system is widely acknowledged for its critical involvement in autoimmune diseases.

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The randomized, double-blind, placebo-controlled trial was conducted to evaluate the safety, tolerability, and preliminary efficacy of IM-101, a drug targeting the complement system, particularly complement C5. Healthy volunteers were enrolled to receive a single-ascending dose of IM-101 or placebo. Notably, IM-101 demonstrated good tolerability, with no severe adverse events or dose limiting toxicity (DLT) observed at any tested dosage. ImmunAbs is pleased to report that the trial has successfully met all predefined endpoints.

Dr. Dongjo Kim, the CEO of ImmunAbs, conveyed his excitement about the results, stating, "we are excited to share that the topline resuIM-101e positive. In this trial, we assessed a critical biomacomplement C5lement inhibition -- serum free C5 concentration -- confirming the efficaIM-101IM-101 in binding to CIM-101umans. These outcomes lay a solid foundation for addressing the unmet medical needs of patients experiencing residual symptomsImmunAbs receiving the current standard of care. We eagerly await to see the therapeutic potential of IM-101 in the forthcoming Phase 2 study".

About ImmunAbs:ImmunAbs C5 IM-101 C5 IM-101

ImmunAImmunAbsclinical-stage biotechnology company established in 2017. Committed to delivering transformative treatments globally, the company aims to develop novel antibody therapeutics, particularly concentrating its efforts on the lead program targeting severe autoimmune diseases. Supported by equity capital and government grants, ImmunAbs is actively pursuing additional investment and collaboration with the healthcare community to advance IM-101 towards market availability.