As pharmaceutical drugs become more potent, targeted, and complex, the importance of systems designed to maintain drug stability and precisely control the delivery of those drugs to the body increases.Therefore, our research and development efforts have focused on materials and devices that can: (1) store one or more drugs, (2) protect them from the body until they are needed, and (3) controllably release the drugs at the desired time.Advances in microfabrication and hermetic sealing technologies have enabled the creation of multi-reservoir drug delivery systems that address these needs.Precise control over the release of drug from each reservoir is enabled by novel formulation techniques, the application of outside energy sources such as lasers, and/or the integration of pre-programmed microprocessors, wireless telemetry, or biosensors.We were the first to demonstrate both in vitro and in vivo, chronic on demand release of drugs stored inside implantable, multi-reservoir systems.Startup companies have proven to be an effective way to quickly translate scientific and technol. discoveries into new medical products that benefit patients.This talk will include some examples of startups developing multi-reservoir drug therapies for ophthalmol. and osteoporosis.