Albertinen-Krankenhaus/Albertinen-Haus gemeinnützige GmbH: 药物管线，专利，临床试验

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项与 Albertinen-Krankenhaus/Albertinen-Haus gemeinnützige GmbH 相关的临床试验

Comparative Effectiveness Study of Transthoracic and Transesophageal Echocardiography in Stroke

The Comparative Effectiveness Study of Transthoracic and Transesophageal Echocardiography in Stroke (CONTEST) aims at assessing the diagnostic value of transesophageal echocardiography (TEE) and transthoracic echocardiography (TTE) with regards to treatment consequences in patients with acute ischemic stroke.

开始日期2017-07-01

申办/合作机构

Universitätsklinikum Hamburg-Eppendorf

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0 项与 Albertinen-Krankenhaus/Albertinen-Haus gemeinnützige GmbH 相关的专利（医药）

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项与 Albertinen-Krankenhaus/Albertinen-Haus gemeinnützige GmbH 相关的文献（医药）

2017-01-01·Urologia Internationalis4区 · 医学

Serum Levels of MicroRNA371a-3p: A Highly Sensitive Tool for Diagnosing and Staging Testicular Germ Cell Tumours: A Clinical Case Series

4区 · 医学

Article

作者: Anheuser, Petra ; Radtke, Arlo ; Wuelfing, Christian ; Kranz, Jennifer ; Belge, Gazanfer ; Dieckmann, Klaus-Peter

INTRODUCTION:

MicroRNA (miR)371a-3p was suggested to be a sensitive and specific new serum biomarker of germ cell tumours (GCTs); however, its clinical usefulness remains unproven.

PATIENTS, METHODS:

In 312 consecutive cases with various testicular diseases, serum levels of miR371a-3p were measured. Measurement results became available only after completion of treatment. Five patients with testicular seminoma were selected for review because of unanticipated clinical courses.

RESULTS:

In each two patients, elevated miR levels heralded undetected primary testicular GCT and metastases despite inconclusive radiological findings. In one case, a normal miR371a-3p level correctly pointed to the absence of metastases contrary to clinical assessment. In all cases, knowledge about the miR371a-3p levels would have altered the clinical management.

CONCLUSIONS:

These cases highlight the exceptional usefulness of the new GCT biomarker. In contrast to classical markers, miR371a-3p can identify primary testicular GCT. The marker can aid in clinical decision making in cases with ambiguous clinical findings.