Article
作者: Xu, Zhe ; Liu, Wenjun ; Guo, Jiang ; Zeng, Yan ; Li, Xiaolan ; Li, Li ; Xie, Liang ; Zou, Yan ; Liu, Xiaoyun ; Yan, Yi ; Tang, Xiaojun ; Ye, Piao ; Wang, Li ; Yang, Yao ; Chen, Lijie ; Deng, Quanmin ; Liu, Chunyan ; Yu, Jing ; Li, Min ; Fu, Qiang ; Ai, Tao ; Li, Qin ; Yu, Xiahui ; Li, Gen ; Liu, Yanru ; Cai, Qiang ; Jiang, Xiaobin ; Liu, Dingyuan ; Wang, Si ; Huang, Yana ; Wan, Deyun ; Xu, Yuxia ; Xie, Lunyan ; Wan, Guangping ; Chen, Lina ; Wang, Xiaofang ; Zhao, Zhiyong ; Hu, Bo ; Liu, Hanmin ; Shi, Mingfang ; Xiang, Long ; Zhang, Benjin ; Shi, Yan ; Li, Yan
BACKGROUNDThe respiratory syncytial virus (RSV) is the main cause of bronchiolitis in infants and interferon (IFN) α is a commercial antiviral drug. The nebulization of IFN α1b could be a viable treatment method. In this study, the therapeutic effects and safety of IFN α1b delivery via nebulization in infant bronchiolitis were investigated in this multi-center prospective study.METHODS AND FINDINGSBronchiolitis patients admitted to 22 hospitals who met the inclusion criteria were enrolled and randomly allocated to four groups: control, IFN Intramuscular Injection, IFN Nebulization 1 (1 μg/kg), and IFN Nebulization 2 (2 μg/kg) groups. All patients were observed for 7 days. The therapeutic effects and safety of different IFN delivery doses and delivery modes were evaluated. Coughing severity change, as scored by the researchers and parents, between days 1 and 3 was significantly different between the IFN Nebulization 2 and control groups. Lowell wheezing score change between days 3 and 5 was significantly different between IFN Nebulization 1 and control groups. There were no significant differences among the four groups regarding the number of consecutive days with fever, three-concave sign, fatigue and sleepiness, and loss of appetite. There were no cases of severe complications, no recurrence of fever, and no regression of mental status.CONCLUSIONSIFN-α1b could more effectively alleviate coughing and wheezing in bronchiolitis. IFN-α1b nebulization had significant advantages in shortening the duration of wheezing and alleviating coughing.
