This study was carried out on 24 dogs. All the dogs were randomly divided into 3 equal groups (n = 6) viz. A, B, and C based on treatment regimen irresp. of sex, breed and age. Six apparently healthy dogs were taken as control (Group D). Hemato-biochem. investigation were performed to measure TLC, RBS, TSP, Albumin, TSH, T3 and T4. The mean values of TLC in groups A, B and C were 13.19 ± 1.14, 13.21 ± 0.87 and 13.43 ± 1.28 resp., quite high in comparison to healthy group 7.89 ± 0.42. RBS in group A, B and C were 69.71 ± 3.84, 85.80 ± 5.88 and 70.89 ± 4.49 resp., while 87.27 ± 2.75 was in control. Post treatment value in group A, B and C were 79.03 ± 3.63, 79.61 ± 4.43 and 80.62 ± 2.42 resp. The total serum protein (g/dL) and albumin (g/dL) of healthy group were 6.12 ± 0.10 and 1.60 ± 0.10 resp., and in treated group were 2.49 ± 0.04, 2.65 ± 0.99 and 2.78 ± 0.09 resp. The mean value T3 (ng/dL), T4 (μg/dL) and TSH (ng/mL) were not differ. The spatial distribution of lesions were head, trunk and limb 36.5%, 40.5% and 23% resp.