Chemotherapy-induced peripheral neuropathy is neurotoxicity that frequently occurs with chemotherapy treatments. This chapter is designed to discuss the current information available including: definition, prevalence, pathophysiol. at nerve fibers, risk factors, physiol. of specific antineoplastic agents on peripheral nervous system, signs/symptoms, diagnostic criteria, and treatment methods. With the number of cancer survivors increasing with improved treatment methods, clinicians must be prepared to address adverse side effects that are present.