Dublin, April 13, 2021 (GLOBE NEWSWIRE) -- The "Global Induced Pluripotent Stem Cell (iPS Cell) Industry Report 2021" report has been added to ResearchAndMarkets.com's offering.
The main objectives of this report are to describe the current status of iPSC research, patents, funding events, industry partnerships, biomedical applications, technologies, and clinical trials for the development of iPSC-based therapeutics.
Since the discovery of induced pluripotent stem cells (iPSCs) a large and thriving research product market has grown into existence, largely because the cells are non-controversial and can be generated directly from adult cells. It is clear that iPSCs represent a lucrative market segment because methods for commercializing this cell type are expanding every year and clinical studies investigating iPSCs are swelling in number.Therapeutic applications of iPSCs have surged in recent years. 2013 was a landmark year in Japan because it saw the first cellular therapy involving the transplant of iPSCs into humans initiated at the RIKEN Center in Kobe, Japan. Led by Masayo Takahashi of the RIKEN Center for Developmental Biology (CDB), it investigated the safety of iPSC-derived cell sheets in patients with macular degeneration.
In another world-first, Cynata Therapeutics received approval in 2016 to launch the world's first formal clinical trial of an allogeneic iPSC-derived cell product (CYP-001) for the treatment of GvHD.
Riding the momentum within the CAR-T field, Fate Therapeutics is developing FT819, its "off-the-shelf" iPSC-derived CAR-T cell product candidate. Numerous physician-led studies using iPSCs are also underway in Japan, a leading country for basic and applied iPSC applications.iPS Cell Market CompetitorsToday, FUJIFILM CDI has emerged as one of the largest commercial players within the iPSC sector. FUJIFILM CDI was founded in 2004 by Dr. James Thomson at the University of Wisconsin-Madison, who in 2007 derived iPSC lines from human somatic cells for the first time ever. The feat was accomplished simultaneously by Dr. Shinya Yamanaka's lab in Japan.In 2009, ReproCELL, a company established as a venture company originating from the University of Tokyo and Kyoto University, made iPSC products commercially available for the first time with the launch of its human iPSC-derived cardiomyocytes, which it called ReproCario.A European leader within the iPSC market is Ncardia, formed through the merger of Axiogenesis and Pluriomics. Founded in 2001, Axiogenesis initially focused on generating mouse embryonic stem cell-derived cells and assays, but after Yamanaka's iPSC technology became available, it became the first European company to license it in 2010. Ncardia's focus is on preclinical drug discovery and drug safety through the development of functional assays using human neuronal and cardiac cells.
In total, at least 68 distinct market competitors now offer various types of iPSC products, services, technologies and therapies.
iPS Cell CommercializationMethods of commercializing induced pluripotent stem cells (iPSCs) are diverse and continue to expand. iPSC cell applications include, but are not limited to:
Since the discovery of iPSC technology in 2006, significant progress has been made in stem cell biology and regenerative medicine. New pathological mechanisms have been identified and explained, new drugs identified by iPSC screens are in the pipeline, and the first clinical trials employing human iPSC-derived cell types have been initiated.
Key Topics Covered:
1. REPORT OVERVIEW1.1 Statement of the Report1.2 Executive Summary
2. INTRODUCTION2.1 Discovery of iPSCs2.2 Barriers in iPSC Application2.3 Timeline and Cost of iPSC Development2.4 Current Status of iPSCs Industry2.4.1 Share of iPSC-based Research within the Overall Stem Cell Industry2.4.2 Major Focuses of iPSC Companies2.4.3 Commercially Available iPSC-Derived Cell Types2.4.4 Relative Use of iPSC-Derived Cell Types in Toxicology Testing Assays2.4.5 Toxicology/Safety Testing Assays using iPSC-Derived Cell Types2.5 Currently Available iPSC Technologies2.6 Advantages and Limitations of iPSCs Technology
3. HISTORY OF INDUCED PLURIPOTENT STEM CELLS (IPSCS)3.1 First iPSC generation from Mouse Fibroblasts, 20063.2 First Human iPSC Generation, 20073.3 Creation of CiRA, 20103.4 First High-Throughput screening using iPSCs, 20123.5 First iPSCs Clinical Trial Approved in Japan, 20133.6 The First iPSC-RPE Cell Sheet Transplantation for AMD, 20143.7 EBiSC Founded, 20143.8 First Clinical Trial using Allogeneic iPSCs for AMD, 20173.9 Clinical Trials for Parkinson's disease using Allogeneic iPSCs, 20183.10 Commercial iPSC Plant SMaRT Established, 20183.11 First iPSC Therapy Center in Japan, 2019
4. RESEARCH PUBLICATIONS ON iPSCS4.1 Categories of Research Publications4.2 Percent Share of Published Articles by Disease Type4.3 Number of Articles by Country
5. IPSCS: PATENT LANDSCAPE5.1 Timeline and Status of Patents5.2 Patent Filing Destinations5.2.1 Patent Applicant's Origin5.2.2 Top Ten Global Patent Applicants5.2.3 Collaborating Applicants of Patents5.3 Patent Application Trends iPSC Preparation Technologies5.4 Patent Application Trends in iPSC Differentiation Technologies5.5 Patent Application Trends in Disease-Specific Cell Technologies
6. CLINICAL TRIALS INVOLVING iPSCS6.1 Current Clinical Trials Landscape6.1.1 Clinical Trials Involving iPSCs by Major Diseases6.1.2 Clinical Trials Involving iPSCs by Country
7. FUNDING FOR iPSCs7.1 Value of NIH Funding for iPSCs7.1.1 NHI's Intended Funding Through its Component Organizations in 20207.1.2 NIH Funding for Select Universities for iPSC Studies7.2 CIRM Funding for iPSCs
8. GENERATION OF INDUCED PLURIPOTENT STEM CELLS: AN OVERVIEW8.1 Reprogramming Factors8.2 Overview of Four Key Methods of Gene Delivery8.3 Comparative Effectiveness of Different Vector Types8.4 Genome Editing Technologies in iPSCs Generation
9. HUMAN iPSC BANKING9.1 Cell Sources for iPSCs Banking9.2 Reprogramming methods used in iPSC Banking9.3 Workflow in iPSC Banks9.4 Existing iPSC Banks
10. BIOMEDICAL APPLICATIONS OF iPSCS10.1 iPSCs in Basic Research10.2 iPSCs in Drug Discovery10.3 iPSCs in Toxicology Studies10.4 iPSCs in Disease Modeling10.5 iPSCs within Cell-Based Therapies
11. OTHER NOVEL APPLICATIONS OF iPSCS11.1 iPSCs in Tissue Engineering11.2 iPSCs in Animal Conservation11.3 iPSCs and Cultured Meat
12. DEAL-MAKING WITHIN THE iPSC SECTOR12.1 License Agreement between FUJIFILM Cellular Dynamics and Sana12.2 Century Therapeutics Closes $160 Million Series C Financing12.3 Bluerock Gains Access to Ncardia's iPSCs-derived Cardiomyocytes12.4 Fate Therapeutics' Deal with Janssen Biotech12.5 Century Therapeutics Acquires Empirica Therapeutics12.6 $250 Million Raised by Century Theraputics12.7 BlueRock Therapeutics Launched with $225 Million12.8 Collaboration between Allogene Therapeutics and Notch Therapeutics12.9 Acquisition of Semma Therapeutics by Vertex Therapeutics12.10 Evotec's Extended Collaboration with BMS12.11 Licensing Agreement between Allele Biotechnology and Astellas12.12 Codevelopment Agreement between Allele & SCM Lifesciences12.13 Fate Therapeutics Signs $100 Million Deal with Janssen12.14 Allele's Deal with Alpine Biotherapeutics12.15 Editas and BlueRock's Development Agreement
13. MARKET OVERVIEW13.1 Global Market for iPSCs by Geography13.2 Global Market for iPSCs by Technology13.3 Global Market for iPSCs by Biomedical Application13.4 Global Market for iPSCs by Cell Types3.5 Market Drivers13.6 Market Restraints
14. COMPANY PROFILES
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