This paper describes that GPC3 is highly expressed in embryonic tissues, but basically not in adults.Abnormal expression is mostly related to tumors.The detection of GPC3 in patients′ tissues or serum can effectively prompt the early diagnosis of liver cancer, the judgment of tumor clin. stages and types, and the prognosis after surgery.It is of great significance to study the mol. mechanism of GPC3 promoting the occurrence and development of HCC and to explore the value of GPC3 in the diagnosis, treatment and prognosis of HCC.