Objective: To study the compatibility of Fengyoujing with polypropylene balls(PP ball) and the low borosilicate glass inner packaging material. Methods: The changes of the microscopic morphol. of the inner wall of the glass bottle were observed by SEM and the corrosion of the sample glass bottle by the drug was also studied at each time point. The contents of arsenic, antimony, lead, cadmium and mercury were determined by coupled plasma-mass spectrometry at various time points under the accelerated condition. Results: The side and bottom of each batch of Fengyoujing sample bottle were smooth and flat, the stress ring(accelerated for 3 or 6 mo) and neck(accelerated for 6 mo) of the sample bottle were slightly uneven, the ion migration was small and far less than the daily allowable intake(oral) under the accelerated condition, which met safety requirements. Conclusion: Fengyoujing has good compatibility with PP ball and the low borosilicate glass inner packaging material.