Fluticasone propionate (Flovent/Flonase, Glaxo) is the main fluoro-corticosteroid currently on the market.It is a 17β-carbothio androstane derivative fluorinated at the 6α position and it is generally obtained starting from flumethasone through several chem. reactions.This article reports results obtained by the Farmabios company with the aim to develop suitable industrial syntheses of flumethasone and fluticasone propionate.An overview of the corticosteroids chem. with special focus to their regio and stereoselective fluorination reactions at the C6 position is therefore outlined.