Rugao People's Hospital

如皋市人民医院|中国江苏省

更新于：2025-05-07

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项与如皋市人民医院相关的临床试验

NCT06241651

/ RecruitingN/AIIT

Conduction System Pacing Versus Biventricular Pacing for Heart Failure Patients with Right Ventricular Pacing Upgraded to Cardiac Resynchronization Therapy: a Prospective Multicenter Non-inferiority Randomized Controlled Study

The present study is a prospective, multicenter, non-inferiority, randomized controlled trail. It aims to investigate whether the efficacy of conduction system pacing (CSP) is non-inferior to biventricular pacing (BiVP) in patients with heart failure and right ventricular pacing (RVP) requiring upgrading to cardiac resynchronization therapy (CRT).

开始日期2024-01-01

申办/合作机构

常州市第二人民医院

[+6]

NCT02430207

/ Unknown statusN/AIIT

Study of Incidence of Pulmonary Embolism During Peroperative Period of Temporary Pacing Via Femoral Vein Versus Subclavian Vein in China

Temporary pacing via femoral vein is used widely in mainland China, because of its feasibility and simplicity. However, pulmonary embolism often occurred after the procedure. It is not known that whether there was any difference in incidence of pulmonary embolism between via different approaches. This randomized and multi-center study was designed to verify whether temporary pacing via subclavian vein has lower incidence than via femoral vein.

开始日期2015-05-01

申办/合作机构

常州市第二人民医院

[+10]

100 项与如皋市人民医院相关的临床结果

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0 项与如皋市人民医院相关的专利（医药）

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252

项与如皋市人民医院相关的文献（医药）

2025-12-01·Asia-Pacific Journal of Oncology Nursing

Latent profile analysis of emotional inhibition in older adults with gastrointestinal tumors: A cross-sectional study

Article

作者: Wang, Xiaoqing ; Zhu, Kaili ; Li, Siyu ; Duan, Peibei ; Guo, Zhangrong ; Zhang, Yue ; Xu, Rui

ObjectiveThis study aimed to explore the current status of emotional inhibition in older adults with gastrointestinal tumors and to analyse its influencing factors.MethodsFrom September to November 2024, 362 older adults with gastrointestinal tumors completed a self-designed questionnaire on demographic and clinical characteristics, an emotional inhibition scale, a self-esteem scale, and a multidimensional scale of perceived social support. Latent profile analysis was used to classify emotional inhibition in the participants, and multiple logistic regression was used to analyse the factors influencing each subgroup.ResultsBased on the level of emotional inhibition, older adults with gastrointestinal cancer were divided into three subgroups: "low emotional inhibition-active disclosure" (40.0%), "medium emotional inhibition" (41.2%), and "high emotional inhibition-disguise feelings group" (18.8%). The multivariate logistic regression analysis showed that sex, living conditions, disease stage, self-esteem level, and perceived social support were factors influencing participants' emotional inhibition (P < 0.05).ConclusionsEmotional inhibition levels vary among older adults with gastrointestinal cancer. Medical staff should consider the characteristics, self-esteem, and perceived social support of the patients. Additionally, more targeted interventions, such as cognitive-behavioural group therapy or mindfulness-based cognitive therapy, should be developed to reduce patients' emotional inhibition.

2025-04-01·Neuropharmacology

CD38-mediated oxytocin signaling in paraventricular nucleus contributes to empathic pain

Article

作者: Jiang, Chenqi ; Hu, Suwan ; Ji, Yawei ; Jiang, Peng ; Jiang, Riyue ; Yang, Xiaolin ; Wang, Di ; Yang, Chun ; Wu, Zifeng ; Bu, Yuchen ; Zhang, Xinying ; Liu, Cunming ; Huang, Chaoli ; Huang, Jingyao ; Yang, Ling ; Wang, Haoran ; Yang, Siqi ; Zhang, Qi ; Wang, Yuanyuan

Empathy plays a crucial role in social communication and the perception of affective states and behavioral processes. In this study, we observed that empathic interaction with a mouse experiencing pain resulted in decreased mechanical pain thresholds and anxiety-like behaviors in its bystander, though the underlying mechanisms remain unknown. We demonstrated that CD38 expression in the paraventricular nucleus (PVN) was upregulated during empathic pain, and the pain and emotions of CD38 knockout (CD38KO) mice as bystanders were not affected. Furthermore, fiber photometry recordings indicated that calcium activities of PVN neurons were increased during empathic pain. Interestingly, direct chemogenetic inhibition of PVN neurons attenuated the hyperalgesia and anxiety-like behaviors associated with empathic pain. In contrast, activating PVN neurons through chemogenetics in CD38KO mice induced hyperalgesia and anxiety-like effects in empathic pain. Oxytocin levels in PVN were upregulated during empathic pain, while CD38KO mice inhibit the upregulation in OXT levels, confirming that CD38 is involved in releasing brain OXT and that the CD38-OXT system in the PVN plays a role in empathic pain. Collectively, CD38-mediated oxytocin signaling in PVN is closely linked to empathic pain through its effect on the activation of PVN neurons, and it could be viable targets for novel empathic behavior interventions.

2025-03-01·Biochemical Pharmacology

Cotargeting of thioredoxin 1 and glutamate-cysteine ligase in both imatinib-sensitive and imatinib-resistant CML cells

Article

作者: Zhang, Chunli ; Hu, Chunping ; Wang, Shuxia ; Fan, Bo ; Liu, Qingyu ; Chen, Ting ; Shi, Xiaofeng ; Sun, Handong ; Cai, Xueting ; Cao, Peng ; Sun, Xiaoyan ; Puno, Pematenzin

Chronic myeloid leukemia (CML) is a type of malignancy characterized by harboring the oncogene Bcr-Abl, which encodes the constitutively activated tyrosine kinase BCR-ABL. Although tyrosine kinase inhibitors targeting BCR-ABL have revolutionized CML therapy, native and acquired drug resistance commonly remains a great challenge. Thioredoxin 1 (Trx1) and glutamate-cysteine ligase (GCL), which are two major antioxidants that maintain cellular redox homeostasis, are potential targets for cancer therapy and overcoming drug resistance. However, how their inhibition is implicated in CML is still unclear. Here, our results revealed that Trx1 was overexpressed in patients with CML compared with healthy donors. Trx1 expression was greater in imatinib-resistant CML cells than in imatinib-sensitive cells. Pharmacological inhibitors of Trx1 attenuated cell growth and reduced colony formation in both imatinib-sensitive and imatinib-resistant CML cells. Furthermore, decreased Trx1 expression enhanced the cytotoxicity of the GCL inhibitor buthionine sulfoximine (BSO). We surmise that the combined inhibition of Trx1 and GCL promotes the induction of hydrogen peroxide and depletes GPX4 expression in CML cells, resulting in ferroptosis in cancerous cells. Finally, the combined inhibition of Trx1 and GCL had a synergistic effect on CML cells in murine xenograft models. These findings offer crucial informationregarding the combined roles ofTrx1 and GCL in triggering ferroptosis in CML and suggestefficacioustherapeutic uses for these systems in this disease.

100 项与如皋市人民医院相关的药物交易

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100 项与如皋市人民医院相关的转化医学

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