Male New Zealand white rabbits were fed on atherogenic cholesterol diet (0.5% in diet), the cholesterol diets containing pantethine (0.5% in diet), soysterol (1.0% in diet), and these 2 drugs for 8 wk.Vitamin E was also added to cholesterol diet containing 2 drugs.The combined treatment for hypercholesterolemia with 2 or 3 drugs reduced the levels of serum total cholesterol (TC), low d. lipoprotein-cholesterol, phospholipids, triglycerides, apolipoprotein B and apolipoprotein E.Hypocholesterolemic action of pantethine or soysterol was increased incrementally by the combined treatment.Liver TC, aorta TC, aorta surface involvement of lipids were reduced.The combined treatment also lowered atheromatous lesion in aorta and coronary artery.