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排名前五的药物类型	数量

非重组凝血因子	1

排名前五的靶点	数量

Fibrinogen(纤维蛋白原)	1

关联

1

项与 Foundation For Biomedical Research And Innovation 相关的药物

Fibrin glue(Foundation For Biomedical Research And Innovation)

靶点

Fibrinogen

作用机制

纤维蛋白原刺激剂

在研机构

Foundation For Biomedical Research And Innovation

原研机构

Foundation For Biomedical Research And Innovation

在研适应症

鼓膜穿孔

非在研适应症-

最高研发阶段临床3期

首次获批国家/地区-

首次获批日期-

1

项与 Foundation For Biomedical Research And Innovation 相关的临床试验

NCT00665886 / Completed临床4期IIT

Randomized Study of Closed Peripheral Intravenous Systems Versus Mounted Open Systems

The purpose of this study is to investigate, in a prospective and randomized fashion, the clinical performance of a closed intravenous system versus an open conventional one, with respect to ease of handling and effectiveness (as defined by time of survival without complications), security provided to professionals and patients against accidental blood exposure or needlestick injury, catheter-related complications such as phlebitis, pain and blockage and overall costs of the two systems.

开始日期2008-03-01

申办/合作机构

Hospital San Carlos, Madrid

[+1]

100 项与 Foundation For Biomedical Research And Innovation 相关的临床结果

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0 项与 Foundation For Biomedical Research And Innovation 相关的专利（医药）

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235

项与 Foundation For Biomedical Research And Innovation 相关的文献（医药）

2024-05-01·Enfermería Clínica (English Edition)

Deductive Care Methodology: Describing and testing modes of care research

Article

作者: Fernández-Batalla, Marta ; González-Aguña, Alexandra ; González-Sotos, León Atilano ; Herrero-Jaén, Sara ; Jiménez-Rodríguez, María Lourdes ; Santamaría-García, José María

OBJECTIVEDefine the modes of procedure of the Deductive Care Methodology (DCM) in the generation of knowledge about person's health care.METHODOLOGYDesign and test of the DCM modes based on three phases: mapping of the DCM, generation of models from this methodology and testing of the models through studies in a clinical context.RESULTSThe DCM presents five levels of abstraction with three modes broken down to 16 types. The modes are: Philosophical Mode to conceptualize and obtain generalities about reality, Mathematical Mode to operate with generalities, and Physical Mode to operationally verify, validating the results and the predictive capacity of the model. This MDC allows the creation of three models: Knowledge Model about Person Care, an ontology of care, Vulnerability Model about the person and Taxonomic Triangulation Model for knowledge management. All models generate products for computational knowledge management. In addition, the models are applied in teaching and generate research with more than a hundred participations in conferences and journals, of which five impact publications (from 2008 to 2022) classified in the categories of Nursing and Informatics are analysed.CONCLUSIONSThe DCM collects prior knowledge to work with certainties, evidence and applying inferences that do not depend on the number of cases or inductive designs. This research presents a formal structure of the DCM with an interdisciplinary orientation between Health Sciences and Computer Sciences.

2024-03-20·Nippon Jibiinkoka Tokeibugeka Gakkai Kaiho(Tokyo)

甲状軟骨形成術２型における機械的性能と安全性を向上させるためのチタンブリッジ改良

作者: Nishimura, Tsutomu ; Sanuki, Tetsuji ; Fukushima, Masanori ; Aburada, Takako

2024-02-01·International Journal of Radiation Oncology*Biology*Physics

Trimodality Therapy With Iodine-125 Brachytherapy, External Beam Radiation Therapy, and Short- or Long-Term Androgen Deprivation Therapy for High-Risk Localized Prostate Cancer: Results of a Multicenter, Randomized Phase 3 Trial (TRIP/TRIGU0907)

Article

作者: Stone, Nelson N ; Yaegashi, Hiroshi ; Tanaka, Nobumichi ; Namiki, Mikio ; Egawa, Shin ; Ohashi, Toshio ; Yorozu, Atsunori ; Konaka, Hiroyuki ; Saito, Shiro ; Mizokami, Atsushi ; Takahashi, Hiroyuki ; Nakagawa, Yoko ; Fukagai, Takashi ; Kikuchi, Takashi ; Momma, Tetsuo

PURPOSEThis phase 3 randomized investigation was designed to determine whether 30 months of androgen deprivation therapy (ADT) was superior to 6 months of ADT when combined with brachytherapy and external beam radiation therapy (EBRT) for localized high-risk prostate cancer.METHODS AND MATERIALSThis study was conducted at 37 hospitals on men aged 40 to 79 years, with stage T2c-3a, prostate-specific antigen >20 ng/mL, or Gleason score >7, who received 6 months of ADT combined with iodine-125 brachytherapy followed by EBRT. After stratification, patients were randomly assigned to either no further treatment (short arm) or 24 months of adjuvant ADT (long arm). According to the Phoenix definition of failure, the primary endpoint was the cumulative incidence of biochemical progression. Secondary endpoints included clinical progression, metastasis, salvage treatment, disease-specific mortality, overall survival, and grade 3+ adverse events. An intention-to-treat analysis was conducted using survival estimates determined using competing risk analyses.RESULTSOf 332 patients, 165 and 167 were randomly assigned to the short and long arms, respectively. The median follow-up period was 9.2 years. The cumulative incidence of biochemical progression at 7 years was 9.0% (95% CI, 5.5-14.5) and 8.0% (4.7-13.5) in the short and long arms, respectively (P = .65). The outcomes of secondary endpoints did not differ significantly between the arms. Incidence rates of endocrine- and radiation-related grade 3+ adverse events for the short versus long arms were 0.6 versus 1.8% (P = .62) and 1.2 versus 0.6% (P = .62), respectively.CONCLUSIONSBoth treatment arms showed similar efficacy among selected populations with high-risk features. The toxicity of the trimodal therapy was acceptable. The present investigation, designed as a superiority trial, failed to demonstrate that 30-month ADT yielded better biochemical control than 6-month ADT when combined with brachytherapy and EBRT. Therefore, a noninferiority study is warranted to obtain further evidence supporting these preliminary results.

100 项与 Foundation For Biomedical Research And Innovation 相关的药物交易

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100 项与 Foundation For Biomedical Research And Innovation 相关的转化医学

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