A Prospective, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of Supplemental Astaxanthin in Healthy Female Adult Participants

Astaxanthin is recognized as a bioactive compound with potential benefits for human health. This study aims to evaluate a specific nutritional supplement impact on markers of oxidative stress, inflammation, lipid levels, blood flow, visual skin markers, measures of longevity, mood and skin condition.

开始日期2022-06-08

申办/合作机构

LycoRed Ltd.

[+1]

NCT05409092

/ CompletedN/AIIT

Influence of Astaxanthin Supplementation on Exercise-Induced Inflammation and Skin Health

Vigorous exercise can stress the body. Consuming special types of diet supplements may help the body recover better from exercise. This includes a bright red supplement called astaxanthin that is found in certain algae and causes the pink-red color in salmon. Astaxanthin is an antioxidant and may protect cells from damage and improve the way the immune system functions. The main purpose of this study is to determine if 4 weeks of consuming astaxanthin improves recovery from 2.25 hours of intensive running on a treadmill. This study will also measure whether or not astaxanthin supplementation improves skin health

开始日期2022-01-19

申办/合作机构

Appalachian State University

[+1]

NCT05537350

/ CompletedN/A

A 12 Weeks of Clinical Study to Evaluate the Efficacy and Consumer Perception of Different Skin Attributes Following Supplementation of an Oral Supplement- Lumenato

Subjects will be enrolled in this clinical study to assess the efficacy of an oral supplement to change the characteristics of facial skin after 4 and 12 weeks of use and obtain consumer perception of the test product through the use of questionnaires.
Study evaluations will include a comprehensive metabolic panel, Cutometer measurements, Canfield's VISIA-CR images, VapoMeter Measurements, and Consumer perception questionnaires.

开始日期2022-01-04

申办/合作机构

LycoRed Ltd.

100 项与安道麦股份有限公司相关的临床结果

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项与安道麦股份有限公司相关的文献（医药）

2026-01-01·Integrated Environmental Assessment and Management

Workshop report: scoping for the development of a proposal for an OECD guidance document on fish vitellogenin assessment

Article

作者: Dang, Zhichao ; Yamamoto, Hiroshi ; Hecker, Markus ; Salinas, Edward R ; Schneider, Suzanne Z ; Brown, Rebecca J ; Weltje, Lennart ; Thorpe, Karen ; Krzykwa, Julie ; Boehler, Svenja ; Fisher, Tom ; Hoeger, Stefan ; Snow, Amy ; Goodband, Tracey ; Mingo, Valentin ; Gao, Zhenglei ; Burden, Natalie ; Wheeler, James R ; Holbech, Henrik ; Brion, Francois ; Villeneuve, Daniel L ; Stahlschmidt, Petra ; Maynard, Samuel K ; Fagundes, Teresa ; Pellizzato, Francesca ; Koerner, Oliver ; Katsiadaki, Ioanna ; Mikkelsen, Frank ; Pearson, Audrey ; Augusiak, Jacqueline ; Aubee, Catherine ; Coady, Katherine K ; Baccaro, Marta ; Maunder, Richard ; Fryer, Mike ; Marini, Joseph ; Kearney, Philippa ; Panter, Grace H ; Jacobs, Miriam ; Eilebrecht, Elke ; Sewell, Fiona

Abstract:

This report summarizes discussions of an international workshop in May 2024, aiming to scope the development needs of a proposal for an Organisation for Economic Cooperation and Development (OECD) Guidance Document on vitellogenin (VTG) analysis and assessment. Vitellogenin, an egg-yolk precursor protein in oviparous species, is an informative marker of possible chemical-induced endocrine activity (particularly estrogenicity). Vitellogenin measurement is included in several standardized test guidelines published by the OECD and USEPA for the assessment of endocrine activity of chemicals in fish (and one in amphibians). However, in vivo VTG data across and within fish species can be highly variable and influenced by both technical and biological factors, affecting the reliability and interpretation of results. This poses a challenge for regulatory decision-making and can trigger potentially unnecessary vertebrate studies or prevent necessary further investigations. The workshop brought together 42 experts from different sectors and geographies to discuss three key aspects regarding VTG assessment: (1) technical/laboratory factors and VTG quantification, (2) data handling and statistics, and (3) interpreting the biological relevance of VTG responses. The workshop participants discussed the development and needs of a guidance document to provide harmonized recommendations, best practices, quality assurance criteria, and minimum reporting standards for VTG assessment in regulatory studies across the different test guidelines. Several areas were identified where further work and discussion are needed to inform on the development of the guidance document, such as the use of historical control data, the identification of potential outliers, the presentation of data, and analysis of case study examples. Provision of such a guidance document will further support the use of VTG as a relevant marker for a key aspect of endocrine activity assessment for regulatory decision-making. A formal project was subsequently accepted into the OECD Test Guideline workplan in April 2025.

2025-11-01·Integrated Environmental Assessment and Management

Pesticide residue levels on crop seeds as diet for birds and mammals after foliar applications at late growth stages

Article

作者: Taylor, Seamus ; Gioutlakis, Michail ; Kragten, Steven ; Ludwigs, Jan-Dieter ; Garcia, Paula ; Schabacker, Jens ; Ristau, Kai ; Foudoulakis, Manousos ; Nopper, Joachim Harald ; Vallon, Martin

Abstract:

Crop seeds that are formed on seed-bearing crops at late growth stages are a potential diet item of birds and mammals feeding in agricultural landscapes and may carry pesticide residues. This potential exposure route for birds and mammals is thus part of the European risk assessment framework for pesticide risk assessment. For assessing the risk, estimated residue concentrations on crop seeds are needed, which are typically expressed as RUD (residue-per-unit-dose) values. However, proposed RUD values for seeds as given in relevant European Union (EU) guidance documents were often not derived from actual crop seeds and are generally based on outdated data with unclear relevance for regulatory purposes. The objective of this work was to provide reliable crop seed RUD values representative for EU conditions and modern pesticides. For this purpose, industry field study data on crop seed residue levels for various pesticides resulting from spray application to crops at late growth stages were gathered and evaluated. This new large dataset is based on 178 residue trials and provides crop-specific data for cereals, sunflower, oilseed rape, and pulses. The analysis revealed significantly lower RUD values across crops than the current default values for use in wildlife risk assessment.

2025-09-01·ENVIRONMENT INTERNATIONAL

A Scheme for Safety Testing and Assessment of Biochemicals under the EU Plant Protection Products Regulation (BiochemPPP-STAS)

Review

作者: Strupp, Christian ; Gürkan, Orçun ; Rignall, Benjamin ; Lamperti, Sara ; Sauer, Ursula G ; Mehta, Jyotigna ; Taylor, Seamus ; Bothe, Hanno ; Ellis, Siân ; Criollo, Rosa ; Werner, Michael ; Douaiher, Marie-Noêlle ; Montagnac, Julie

Biochemicals (e.g. substances that originate from nature) are often of lower risk to humans and the environment. Nonetheless, when intended for use as active substances in the European Union (EU), they are subject to the same, extensive data requirements as conventional active substances. This impairs their applicability to support a sustainable agriculture. Here, a Scheme for Safety Testing and Assessment of Biochemicals under the EU Plant Protection Products Regulation (BiochemPPP-STAS) is proposed. The BiochemPPP-STAS provides a flexible approach to identify relevant endpoints and studies, the scientific rationale to justify the waiving of studies that would not contribute to the safety assessment and general advice to prepare a 'fit-for-purpose' dossier for approval of the biochemical active substance. If the background exposure to the naturally occurring counterpart of the biochemical active substance is not substantially increased through its agricultural use, there is no relevant exposure and further risk assessments are not needed. Prior to the generation of new data, all available information is retrieved and evaluated to address areas of concern and resulting uncertainties. Preferably, data needs are identified following an iterative process, in close alignment between applicant and authority. A base dataset is generated to determine triggers of concern that require follow up in vertebrate animal intensive studies, which are, thus, only conducted as a last resort. To facilitate its regulatory applicability, the BiochemPPP-STAS has been closely aligned with EU legislation. Nonetheless, it has been designed generically and can be adapted to fulfil the legal requirements implemented in other jurisdictions.

项与安道麦股份有限公司相关的新闻（医药）

2024-10-24

·美通社

Lycored推出Lycomato™ Beadlets ，拓展旗舰健康提取物的应用和品牌

新泽西州布兰奇堡 2024年10月24日 /美通社/ -- 食品、饮料和膳食补充剂产品天然类胡萝卜素的全球领导者 Lycored 推出了Lycomato 6™ Beadlets 5% ，这是其首屈一指的抗炎解决方案的新交付形式。此版本与他们的旗舰健康提取物Lycomato 6 （以前称为Lyc-O-Mato ® ）的品牌更新同时发布。在品牌中添加6强调了配方中六种番茄基植物营养素的力量，包括英雄番茄红素、植物甾醇、植物烯、植物氟烯、生育酚和β-胡萝卜素。这些组件独立协同工作，从内部支持永恒的衰老和美丽。超过25项已发表的研究证明了Lycomato 6 全成分在对抗炎症和氧化应激方面的有效性，包括最近发表在抗氧化剂上的一项新的临床前研究表明， Lycomato 6 可以改善线粒体功能，减少氧化应激，并防止细胞损伤-所有这些因素都会减缓细胞老化过程并支持长寿。创新的干燥形式为Lycomato 6 开辟了更多的应用机会，包括软糖、胶囊、粉末饮料和片剂，为品牌提供了向消费者介绍Lycomato 6 抗炎功效的新方法。 Lycored商业高级副总裁Tammi Higgins表示： “随着对永恒老化解决方案的需求持续增长，我们很高兴能够扩大Lycomato 6 的应用潜力，并为我们的客户提供满足消费者需求的新机会。” Lycored商业高级副总裁Tammi Higgins表示： “Lycomato 6 是一位全面的抗炎超级英雄，新的品牌有助于将其协同作用与番茄红素本身的协同作用区分开来。” Lycored科学价值与战略主管Elizabeth Tarshish博士将于日本标准时间11月19日下午2点在即将举行的网络研讨会上讨论Lycomato 6 背后的科学，重点介绍近期和关键的科学知识以及应用机会。可在 https://respublica.zoom.us/webinar/register/1517284975856/WN_iyMHS3BSRCyc50kwzZV1Tg 注册关于Lycored Lycored是一家国际公司，通过将大自然的善良与尖端科学相结合，提供影响幸福感的感官之旅，在探索内在美方面处于领先地位。 Lycored于1995年在以色列成立，是用于食品、饮料和膳食补充剂产品的天然类胡萝卜素的全球领导者。如需了解更多信息，请访问 www.lycored.com 。联系 Julia Matteson FoodMinds +1 617 779 1836 jmatteson@foodminds.com

引进/卖出

2024-04-22

·PRNewswire

ADAMA Launches New Cereal Fungicide Avastel® for Superior Disease Control and Long-lasting Protection

TEL AVIV, Israel, April 22, 2024 /PRNewswire/ -- ADAMA Ltd. (SZSE 000553), a leading crop protection company, announced the launch of Avastel®, a new broad-spectrum T2 fungicide for cereal growers across Europe, that delivers a new standard of efficacy, control, and long-lasting protection against a broad spectrum of diseases. Avastel® combines two trusted Active Ingredients – a carboxamide (SDHI) with triazole (DMI) – for outstanding control of Septoria, Brown Rust, Yellow Rust, Net Blotch, and other diseases in various cereals. It's powered by ADAMA's unique Asorbital® Formulation Technology for better uptake and faster migration within the leaf tissue, ensuring increased resistance to washout and excellent retention that mitigates weather uncertainty around spray times. With Avastel®, European farmers who are under pressure to combat Septoria, Rust, and other key diseases can gain peace of mind. Avastel® has powerful curative and long-term preventive effects against disease, resulting in a stronger flag leaf which is crucial for maximizing yields. In field trials, Avastel® brought better protection against Septoria and increased yields, compared with competing products. "European farmers are facing increased resistance to Septoria and other diseases, while simultaneously needing to produce a high yield," said Alex Mills, Global Head of Fungicides at ADAMA. "At ADAMA, we invested in developing Avastel®, a breakthrough fungicide that contains two best-in-class Active Ingredients as well as our innovative Formulation Technology. Avastel®'s curative and preventive effects deliver consistent high performance for high-risk, high-yield crops in a single smart solution. Thanks to ADAMA's proprietary Asorbital® Formulation Technology, farmers in complex agronomic situations have a solution they can rely on." Avastel® is a broad label fungicide that is suitable for use in crops such as wheat, barley, rye, and triticale. It is part of ADAMA's new European cereal fungicide portfolio which began rolling out in 2023. About ADAMA ADAMA Ltd. is a global leader in crop protection, providing practical solutions to farmers across the world to combat weeds, insects and disease. Our culture empowers ADAMA's people to actively listen to farmers and ideate from the field. ADAMA's diverse portfolio of existing active ingredients, coupled with its leading formulation capabilities and proprietary formulation technology platforms, uniquely position the company to develop high-quality, innovative and sustainable products, to address the many challenges farmers and customers face today. ADAMA serves customers in over 100 countries globally. For more information, visit us at and follow us on Twitter® at @ADAMAAgri. ADAMA Contact: Tal Moise Public Relations Email: [email protected] Logo - SOURCE ADAMA Ltd.

2024-04-09

·PRNewswire

ADAMA Launches New Multi-Crop, Broad Spectrum Fungicide Maxentis® for Improved Disease Control and Increased Yield

BEIJING and TEL AVIV, Israel, April 9, 2024 /PRNewswire/ -- ADAMA Ltd. (SZSE 000553), a leading crop protection company, has announced the launch of Maxentis ®, a new versatile fungicide that delivers reliable control over a broad range of diseases in wheat, barley, and oilseed rape, to increase yields and improve income. Maxentis® delivers dependable control of Septoria, Yellow Rust, and Brown Rust in wheat; Leaf Blotch, Net Blotch, and Rust in barley; and Sclerotinia and Alternaria in OSR, helping bring peace of mind to farmers while simplifying and reducing the expense of their spray programs. In high potential wheat areas Maxentis® can be used as a T1 application in a spray program with other fungicides, or as a standalone T1 or T2 broad spectrum product in lower-potential areas. The non-SDHI formulation makes it an excellent partner for spraying programs, allowing farmers the flexibility to use an SDHI combination at the critical flag leaf stage of the wheat. Two modes of action are combined to enhance the impact of Maxentis®. This means that fungal diseases are controlled across multiple growth stages of the disease, resulting in greater efficacy and healthier crops. Maxentis® improves yields, while the ability to control numerous diseases in multiple crops with a single product increases convenience, reduces complexity and lowers costs, resulting in increased income for farmers. "Farmers across Europe expressed a need for more versatile, broad label products that can serve multiple crops and combat a range of diseases, without requiring them to juggle a complicated mix of products," says Alex Mills, Global Head of Fungicides at ADAMA. "We responded with the value innovation that is an integral part of ADAMA. Maxentis® delivers dependable control of the most important diseases in wheat, barley, and OSR, in a single convenient product that's ready to go when you are. Thanks to its flexibility and reliability, farmers can produce higher yields with less stress." Maxentis ® is part of ADAMA's new European cereal fungicide portfolio, which it began rolling out in 2023. Launches will continue across the continent, UK, and Ireland throughout 2024. About ADAMA ADAMA Ltd. is a global leader in crop protection, providing practical solutions to farmers across the world to combat weeds, insects and disease. Our culture empowers ADAMA's people to actively listen to farmers and ideate from the field. ADAMA's diverse portfolio of existing active ingredients, coupled with its leading formulation capabilities and proprietary formulation technology platforms, uniquely position the company to develop high-quality, innovative and sustainable products, to address the many challenges farmers and customers face today. ADAMA serves customers in over 100 countries globally. For more information, visit us at and follow us on Twitter® at @ADAMAAgri. ADAMA Contact: Tal Moise Public Relations Email: [email protected] Logo: SOURCE ADAMA Ltd.

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100 项与安道麦股份有限公司相关的转化医学

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