预约演示
更新于：2025-08-14
Topcon Corp.
更新于：2025-08-14
概览
关联
JPRN-UMIN000027109
Evaluation of measurement performance of ophthalmic instruments with crystalline lens opacity - Evaluation of performance of ophthalmic instruments with lens opacity
NCT03439774
Comparative Study of the Topcon Tonometers CT-800 and TRK-2P and the Haag-Streit Goldmann Manual Tonometer (Predicate) to Demonstrate Conformance to ANSI Z80.10-2014 Ophthalmic Instruments - Tonometers, to the FDA Guidance for Industry and FDA Staff, Tonometer-Premarket Notification [510(k)] Submissions, and to the Applicable Supplemental Information Sheet and Comparison of Pachymetry Values for Topcon TRK-2P With the Topcon SP-1P (Predicate)
NCT03107104
Topcon DRI OCT Triton (Plus) Fundus Autofluorescence and Fluorescein Angiography Image Quality Evaluation Study
100 项与 Topcon Corp. 相关的临床结果
登录后查看更多信息
登录后查看更多信息
2025-07-07RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Regional Variability in Choroidal Vascularity Index and Association with Intervortex Anastomoses in Polypoidal Choroidal Vasculopathy
Article
作者: Akiba, Masahiro ; Chong Teo, Kelvin Yi ; Gilead, Noa ; Gemmy Cheung, Chui Ming ; Chong, Yu Jeat
Purpose::
To evaluate the regional variation in choroidal vascularity index (CVI) in polypoidal choroidal vasculopathy (PCV) and association with intervortex anastomosis (IA).
Methods::
Fifty-one eyes with PCV were included. Volumetric optical coherence tomography (OCT) scan was acquired on a 6 X 6mm2 macula area and divided into 36 individual squares. CVI was calculated using an automated algorithm. The different regions were: central, superior-temporal (ST), inferior-temporal (IT), superior-nasal (SN), inferior-nasal (IN). IA was detected using en-face OCT.
Results::
The mean (SD) CVI of the whole macula was 61.01% (1.46), similar to all the other regions (pairwise comparison, all P >0.05). CVI range was 48.75%-69.48%. The mean (SD) coefficient of variation (CoV) was 1.9% (1.3).IA was present 64.7% of eyes. Eyes with IA had higher mean (SD) whole macula CVI (61.39% (1.43) versus 60.30% (1.26), P=0.01) and SFCT (265.8 µm (103.4) versus 190.1 µm (78.3), P =0.01) compared those without; and a lower mean (SD) CVI range (6.08% (2.38) versus 8.27% (4.13), P =0.04). Although the mean CVI CoV was lower in eyes with IA, 1.6% (0.8) versus 2.4% (1.8), this was not statistically significant, P=0.14.
Conclusion::
Regional CVI variability may precede the formation of IA supporting the hypothesis that IA could be a compensatory mechanism for choroidal congestion.
2025-07-01INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Effect of Deep Optic Nerve Head Morphology on Lamina Cribrosa and Peripapillary Scleral Configurations in Healthy Eyes.
Article
作者: Saito, Hitomi ; Aihara, Makoto ; Enomoto, Nobuko ; Weinreb, Robert N ; Araie, Makoto ; Kikawa, Tsutomu ; Leung, Christopher Kai Shun ; Kambayashi, Mitsuki ; Higashide, Tomomi ; Zangwill, Linda M ; Iwase, Aiko ; Tomita, Goji ; Murata, Hiroshi ; Sugiyama, Kazuhisa ; Kim, Tae-Woo ; Miki, Atsuya ; Ohno-Matsui, Kyoko ; Nakazawa, Toru
Purpose:
The purpose of this study was to investigate the relationship among deep optic nerve head (ONH), lamina cribrosa (LC), and peripapillary sclera (pSc) configurations in healthy eyes.
Methods:
This prospective cross-sectional study included 205 healthy eyes of 141 subjects. Multivariable linear mixed models identified factors associated with LC curvature index, prelaminar thickness (PLT), pSc angle, and LC depth (LCD). Explanatory variables included age, gender, intraocular pressure, axial length (AXL), visual field sensitivity, disc area, disc ovality, disc torsion, Bruch's membrane opening (BMO)-minimum rim width (MRW), BMO and anterior scleral canal opening (ASCO) area, peripapillary zone area with and without Bruch's membrane (PPZ+BM/-BM), and peripapillary choroidal thickness (pChT). A sub-analysis was conducted by dividing the eyes at the median AXL.
Results:
LC curvature was flatter in eyes with large PPZ-BM, long AXL, and shallow LCD (P = 0.002, P = 0.015, and P = 0.042, respectively). Similar factors exhibited consistent effects in longer AXL eyes, whereas different factors, BMO-MRW, ASCO-area, and pSc-angle, were associated in shorter AXL eyes (P = 0.006, P = 0.012, and P = 0.018. respectively). PLT was thinner in eyes with thin BMO-MRW, large ASCO area, and young age (P < 0.001, P < 0.001, and P = 0.009, respectively). The pSc angle was steeper in eyes with long AXL and large PPZ+BM (P < 0.001). LCD was deeper in eyes with thick pChT, thin BMO-MRW, and small ASCO area (P < 0.001, P < 0.001, and P = 0.004, respectively).
Conclusions:
Novel associations between LC configurations with scleral canal size, PPZ+BM/-BM, and BMO-MRW were found after correction for confounding deep ONH morphologies. Given that these structures are associated with glaucomatous changes, these inter-structure correlations should be considered when distinguishing LC changes between healthy and glaucomatous eyes.
2025-05-01Ophthalmology science
Quantitative Mapping of Posterior Eye Curvature in Children Using Distortion-Corrected OCT: Insights into Temporal Region Morphology
Article
作者: Kuji, Riku ; Tamura, Masato ; Akiba, Masahiro ; Yoshino, Kenichi ; Mihashi, Toshifumi ; Sugiura, Yoshimi ; Mino, Toshihiro ; Takahashi, Yosuke ; Oshika, Tetsuro ; Moriguchi, Yoshikiyo ; Hiraoka, Takahiro
Purpose:
To explore the curvature distribution in the posterior eye among school-aged children using distortion-corrected widefield OCT and its relationship with biometric variables.
Design:
Cross-sectional, observational study.
Participants:
Eighty-eight children.
Methods:
A swept-source-OCT prototype system with a repetition rate of 400 kHz was used to capture widefield retinal OCT images with a field-of-view of 68 × 68 degrees. The acquired OCT images were corrected for distortion using ocular optical information obtained separately for each eye. The posterior eye curvature was represented by the Gaussian curvature which was derived from Bruch's membrane segmentation. The mean Gaussian curvature was assessed across 4 regions set centered on the fovea, considering axial length (AL), refractive error, age, and choroidal thickness (ChT). Additionally, we identified the entry site of the long posterior ciliary artery (LPCA) into the choroid.
Main Outcome Measures:
Local curvature distribution in the posterior eye.
Results:
A total of 176 eyes were imaged, with 7 excluded due to low image quality. Analysis of 169 OCT images revealed bilateral symmetry in choroidal vascular patterns and posterior eye curvature. Significant correlations were noted between mean curvature and AL, refractive error, and ChT in the superior, macular, and inferior regions. However, the temporal region exhibited reversed correlation trends. A local maximum curvature point was commonly observed in the temporal region, potentially linked to the LPCA entry site.
Conclusions:
Our study provided a quantitative analysis of posterior eye curvature in children, highlighting a local maximum curvature point in the temporal region. Interestingly, the relationships between mean curvature and biometric variables in the temporal region contradicted those in the other 3 regions. Further investigation is necessary to elucidate its origin and implications for ocular development.
Financial Disclosures:
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
2025-08-14
IPO引进/卖出财报
2025-08-12
带量采购核酸药物引进/卖出
2025-08-11
财报IPO生物类似药
100 项与 Topcon Corp. 相关的药物交易
登录后查看更多信息
100 项与 Topcon Corp. 相关的转化医学
登录后查看更多信息
组织架构
使用我们的机构树数据加速您的研究。
登录
或
管线布局
2025年08月28日管线快照
无数据报导
登录后保持更新
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
营收
使用 Synapse 探索超过 36 万个组织的财务状况。
登录
或
科研基金(NIH)
访问超过 200 万项资助和基金信息，以提升您的研究之旅。
登录
或
投资
深入了解从初创企业到成熟企业的最新公司投资动态。
登录
或
融资
发掘融资趋势以验证和推进您的投资机会。
登录
或
Eureka LS:
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用