Through the development of a two-dimensional (2D) full quantum simulation, the properties of carbon nanotube field-effect transistors (CNTFETs) at varying tube diameters and dielec. constants of CNT have been exhaustively investigated.Simulations were conducted using the self-consistent solution of 2D Poisson-Schrodinger equations within the nonequilibrium Green′s function (NEGF) formalism.This paper investigates the short-channel effects on CNTFET performance using the NEGF function.The numerical model facilitates a greater understanding of the phys. mechanisms at play and guides the design of CNTFETs to enhance transistor performance.This research aims to improve the efficacy of CNTFETs by enhancing device parameters and gaining a deeper understanding of CNT characteristics.The short-channel effect is a significant concern in CNTFETs as the channel length decreases.Using CNTFET math. modeling, we analyzed the switching speed (I_ON/I_OFF) ratio and the short channel effect (SCE).We have analyzed the effects of drain-induced barrier lowering (DIBL), subthreshold swing (SS), and carrier injection velocity (V_inj) for finding the short channel effect of CNTFETs with varying tube diameters and dielec. constantsThis paper also illustrates the influence of gate capacitance(C_G), output conductance (g_d), voltage gain(A_V) & transconductance (g_m) on the different parameters of the CNTFET.This comparative anal. demonstrates that a reduced transconductance corresponds to a larger bandgap, indicating a firmer control of the gate over the channel.If the channel or tube diameter is reduced, the bandgap energy will exhibit an increasing pattern, resulting in a thickening of the tunneling barrier, a reduction in the drain transconductance, and an increase in the threshold voltage, all of which will result in an increase in SS.The findings provide important insights into the short-channel behavior of CNTFETs and offer recommendations for optimizing their performance in future nanoelectronics applications.This study shows that Ion current increase 57.642 % for varying tube diameter 1.0179 nm to 1.95575 nm for dielec. constant 3.9.And the Ion current increase 100 % for changing dielec. constant 3.9 to 80 using 1.4877 nm of tube diameterAt smaller tube diameters, the ION/IOFF ratio is nearly three times greater for materials with a higher dielec. constantAlso, the findings demonstrate that for lower tube diameter 1.0179 nm output conductance will increase by 50.30 % & using higher tube diameter 1.95575 nm the output conductance will increase by 32.88 % by varying dielec. material permittivity from 3.9 (SiO₂) to 80 (Ti₂O₃).

2025-04-21·Cancer Research

Abstract 1000: Impact of GSTP1 Ile105Val genetic polymorphism on cervical cancer risk among Bangladeshi female population

作者: Hasan, Md Mehedi ; Rahman, Md. Mustafizur ; Munna, Abdur Rahman ; Hossain, Amir

Background and aim:Worldwide, cervical cancer is both the fourth-most common cause of cancer and the fourth-most common cause of death from cancer in women. Approximately 90% of deaths from cervical cancer occurred in low- and middle-income countries. Glutathione S-transferase P1 (GSTP1) is a xenobiotic metabolizing (detoxifying) enzyme. Studies have suggested that GSTP1 genetic polymorphism in exon 5 (Ile105Val, GSTP1 A313G) may play important role in determining susceptibility to cervical cancer, though the data have often been inconsistent.Objective:This study aimed to investigate the association of the GSTP1 Ile105Val polymorphism with the prevalence and risk of cervical cancer in Bangladeshi females. We also aimed at finding any correlation between demographic variables and polymorphic genotypes in cervical cancer patients.Materials and Methods:Polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) were performed to genotype GSTP1 polymorphism (Ile105Val). Genomic DNA was isolated from venous blood collected from 117 pathologically diagnosed squamous cell cervical cancer patients and 150 healthy females.Results:The homozygous variant (G/G) genotypes and heterozygous plus variant (A/G+G/G) genotypes showed 3.17 fold (OR= 3.1746, 95% CI= 1.037 to 9.7187, p=0.043) and 1.71 fold (OR= 1.7143, 95% CI= 1.0425 to 2.8189, p=0.0337) increased risk of cervical cancer when compared to homozygous wild type (A/A) genotypes, respectively. The allele frequency distribution of A and G in cases and controls also associated with increased cervical cancer risk (OR= 1.677, 95% CI= 1.1129 to 2.5271) and the result is statistically significant (p<0.05). However, there was no significant combined effects of demographic variables (p>0.05) and GSTP1 genotypes in cancer development.Conclusion:GSTP1genetic polymorphism (Ile105Val) could influence susceptibility to cervical cancer among Bangladeshi women.Citation Format:Md. Mustafizur Rahman, Md Mehedi Hasan, Abdur Rahman Munna, Amir Hossain. Impact of GSTP1 Ile105Val genetic polymorphism on cervical cancer risk among Bangladeshi female population [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 1000.

2025-04-18·Current Pharmaceutical Biotechnology

Microbial Influences: The Microbiome's Impact on Pancreatic Cancer Development and Progression

Article

作者: Fakruddin, Md. ; Sultana Jime, Jinath ; Suprova, Suraiya Nasrin ; Shishir, Md. Asaduzzaman ; Bulbul, Nayeema ; Bin Mannan, Shahnewaj ; Ul Islam, Bakhtiar ; Chowdhury, Zarifah ; Anam, Mohammad Badrul

Abstract:Pancreatic ductal adenocarcinoma (PDAC) presents significant challenges due to its dense stromal environment, which impedes treatment efficacy. Recent molecular and phenotypic analyses have enhanced our understanding of PDAC, driving the development of targeted therapies. Emerging research highlights the crucial role of the pancreatic tumor microbiome in PDAC initiation and progression. However, the specific mechanisms influencing the tumor microenvironment (TME) and systemic immunity remain incompletely understood. Studies have elucidated various genetic mutations, signaling pathways, and cellular interactions driving PDAC progression, aiding the development of targeted therapies. Despite these advances, overall survival rates for PDAC patients remain low, necessitating novel therapeutic strategies. Therapeutic strategies targeting the microbiome hold significant potential. Therapeutic strategies aimed at modulating microbiomes demonstrate significant potential for treating diseases and enhancing human well-being. Early research indicates that manipulating the microbiome could alter the TME to enhance the efficacy of existing treatments and lead to new therapeutic modalities. Modulating microbiomes might improve the delivery and effectiveness of chemotherapeutic agents or sensitize the tumor to immunotherapy, potentially revolutionizing PDAC treatment paradigms. Microbes can indirectly contribute to pancreatic cancer by inducing chronic inflammation and immune dysregulation. Microbes create a pro-inflammatory environment conducive to cancer development. This persistent inflammation can lead to genetic mutations and a suppressed immune response, fostering an environment where cancer cells can thrive. This review synthesizes current evidence on how the microbiome influences PDAC development and progression, emphasizing its potential for early disease detection and novel therapeutic strategies. Early detection, particularly in premalignant conditions such as chronic pancreatitis and intraductal papillary mucinous neoplasm (IPMN), is crucial for improving patient outcomes through timely intervention.

100 项与 Dhaka International University 相关的药物交易

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100 项与 Dhaka International University 相关的转化医学

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