-Clinical Efficacy of Pharmacological Treatments Targeting Energy Metabolism, Evaluated by Gait Analysis, on Motor Function in Parkinson's Disease Patients

Consistent evidence suggests that mitochondrial dysfunction plays a crucial role in Parkinson¿s disease pathogenesis.
Inhibition of complex I of the mitochondrial electron transport chain is sufficient to reproduce biochemical and pathological features of Parkinson¿s Disease in animal models (PD). Alterations of mitochondrial energy metabolism may intervene in PD pathogenesis by inducing inflammation, generation of reactive oxygen species (ROS), and neurodegeneration. The Nuclear factor erythroid 2-related factor 2 (Nrf2) is a regulator both of mitochondrial function and biogenesis, and of cellular resistance to oxidative stress, and may represent a novel target of PD disease-modifying therapies.
The aims of the present study are to validate indicators of energy metabolism as biomarkers in PD patients and to evaluate the efficacy of drugs and natural food supplements acting on the Nrf2 pathway in improving motor impairment and Gait in PD patients.

开始日期2023-12-01

申办/合作机构

Fondazione Santa Lucia

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100 项与 Universita degli Studi di Roma \"Foro Italico\" 相关的临床结果

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0 项与 Universita degli Studi di Roma \"Foro Italico\" 相关的专利（医药）

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214

项与 Universita degli Studi di Roma \"Foro Italico\" 相关的文献（医药）

2025-06-01·JACC. Advances

The Diagnostic and Prognostic Value of the 12-Lead ECG in Arrhythmogenic Left Ventricular Cardiomyopathy

Article

作者: Baban, Anwar ; Targetti, Mattia ; Lanzillo, Chiara ; Novelli, Giuseppe ; Narducci, Maria Lucia ; Graziosi, Maddalena ; Fanisio, Francesca ; Canestrelli, Stefano ; Gargaro, Alessio ; Pieroni, Maurizio ; Lopez, Carles Diez ; Gandjbakhch, Estelle ; Toso, Elisabetta ; Romeo, Fabiana ; Cappelletto, Chiara ; Casella, Michela ; Crescenzi, Cinzia ; Pelargonio, Gemma ; Re, Federica ; Fusco, Armando ; Autore, Camillo ; Drago, Fabrizio ; Olivotto, Iacopo ; Barile, Ludovica ; Sangiuolo, Federica Carla ; Catalano, Costantina ; Stefanini, Matteo ; Calò, Leonardo ; Tini, Giacomo ; Gaita, Fiorenzo ; Biagini, Elena ; Dello Russo, Antonio ; Sinagra, Gianfranco ; Merlo, Marco ; Musumeci, Maria Beatrice ; Toto, Federica ; Stolfo, Davide ; Radesich, Cinzia ; Cicenia, Marianna ; Ciabatti, Michele ; Paiotti, Elena ; Di Marco, Andrea ; Fedele, Elisa ; Laredo, Mikael ; Peretto, Giovanni ; Mango, Ruggiero ; Martino, Annamaria ; Gasperetti, Alessio ; Perotto, Maria

BACKGROUND:

Electrocardiographic findings in arrhythmogenic left ventricular cardiomyopathy (ALVC) have been limited to small studies.

OBJECTIVES:

The authors aimed to analyze the electrocardiogram (ECG) characteristics of ALVC, to correlate ECG with cardiac magnetic resonance and genetic data, and to evaluate its prognostic value.

METHODS:

We reviewed data of 125 consecutive patients with ALVC (81.5% desmoplakin pathogenic/likely pathogenic variants). The composite endpoint of major arrhythmic events (MAEs) included sudden cardiac death, aborted sudden cardiac death, and appropriate implantable cardioverter-defibrillator shock. Predictors of MAE were evaluated with logistic regression.

RESULTS:

ALVC showed distinct ECG signs, including left posterior fascicular block (LPFB) (13.6%), pathological Q waves (26.4%), R/S ratio in V₁ ≥0.5 (26.4%), and SV1 + RV6 ≤12 mm and RI + RII ≤8 mm (44%). Fifteen (12%) patients had a normal ECG. MAE occurred in 35 patients (28%). In multivariable analysis, LPFB (OR: 4.7; 95% CI: 1.2-18.3), syncope (OR: 84.95; 95% CI: 14-496), transmural late gadolinium enhancement (OR: 9.95; 95% CI: 2.3-36), and right ventricular ejection fraction (OR: 0.92; 95% CI: 0.87-0.97) were the independent predictors of MAE. The model including these 4 variables achieved a remarkable predictive capability (area under the curve: 0.9). In the primary prevention scenario, with Cox regression, LPFB (HR: 3.98; 95% CI: 1.3-12.0), syncope (HR: 19.13; 95% CI: 5.8-63.0), and transmural late gadolinium enhancement (HR: 10.57; 95% CI: 2.9-38.0) were independent predictors of MAE.

CONCLUSIONS:

In ALVC, ECG is a valuable diagnostic tool and may have a relevant prognostic role, since LFPB is a strong and independent predictor of MAE.

2025-05-01·JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS

Cross-cultural adaptation and validation of a revised Italian Anterior Knee Pain Scale version

Article

作者: RUM, Lorenzo ; SAUCHELLI, Alessio P. ; CIATTI, Riccardo ; NUTARELLI, Sebastiano ; Rum, Lorenzo ; Nutarelli, Sebastiano ; ROCCHI, Jacopo E. ; Sauchelli, Alessio P ; Rocchi, Jacopo E ; Ciatti, Riccardo

BACKGROUND:

The study aimed to validate a revised Italian version of the Anterior Knee Pain Scale (AKPS) by addressing shortcomings in previous adaptations and following the COSMIN guidelines to ensure robust psychometric evaluation.

METHODS:

One hundred thirty patients with anterior knee pain symptoms were recruited, with 65 undergoing a retest after 7 days to assess the scale's reliability. Structural validity was assessed through confirmatory factor analysis (CFA) to evaluate the scale's dimensionality. Internal consistency was measured using Cronbach's alpha, while test-retest reliability was assessed using the intraclass correlation coefficient (ICC). Measurement error was evaluated using the standard error of measurement (SEM) and the smallest detectable change (SDC). Construct validity was examined by correlating the AKPS with other established scales, including the Knee Injury and Osteoarthritis Outcome Score, Internal Knee Documentation Committee, Victorian Institute of Sport Assessment - Patella, Short-Form 36 Health Survey, and the Visual Analogue Scale.

RESULTS:

The CFA supported a three-factor model encompassing pain intensity and interference, functional limitations in daily activities, and knee structural and functional issues. The scale demonstrated good internal consistency (Cronbach's α=0.79) and excellent test-retest reliability (ICC=0.91), with low measurement error (SEM<5%). Construct validity was confirmed through moderate-to-strong correlations with related scales, particularly in domains related to pain intensity, symptoms, and daily functioning.

CONCLUSIONS:

The newly validated scale, demonstrating strong psychometric properties, meets international standards for clinical assessment tools, making it a reliable and effective instrument for assessing anterior knee pain in the Italian context.

2025-04-01·JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS

Moderate anxiety may improve functional balance in older women with low muscle strength: a preliminary observation

Article

作者: Trentin, Chiara ; DI Russo, Francesco ; Tocci, Nicoletta ; Forte, Roberta ; Lucia, Stefania

BACKGROUND:

Anxiety commonly affects older individuals with negative consequences on various physical and motor performances such as balance. When coupled with age-related muscular strength loss, the effects on the ability to perform daily tasks could be particularly detrimental, particularly in older women who are more susceptible to anxiety, muscular strength losses and falls. The study aimed to verify the effects of anxiety on balance performance in relation to muscular strength level in healthy older women.

METHODS:

Twenty-six individuals aged over 64 years underwent tests for anxiety, static and dynamic balance, and hand-grip strength. Two-way ANOVA was performed with anxiety (anxious vs. non-anxious) and strength (high vs. low) as independent variables.

RESULTS:

A significant main effect of anxiety and a significant interaction anxiety*strength for static balance were observed. The analysis of the interaction revealed a significant effect of anxiety on the non-preferred one-foot balance with differences between low and high strength subjects; for low levels of strength, anxious woman performed significantly better than non-anxious, for high levels of strength, anxiety had no effect.

CONCLUSIONS:

Moderate levels of anxiety may support balance performance in low strength condition. These findings if further verified on larger samples could add important information on the role of anxiety on motor performance in aging.

100 项与 Universita degli Studi di Roma \"Foro Italico\" 相关的药物交易

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100 项与 Universita degli Studi di Roma \"Foro Italico\" 相关的转化医学

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