BioGenerator Ventures

据创鉴汇不完全统计，上周（4月21日至4月27日）全球大健康领域共披露融资事件26起，总额超57亿元。按照金额划分，亿元及以上融资13起。按照已披露的融资轮次划分，早期融资（B轮以前）14起，中后期融资（B轮及以后）7起。生物医药领域共11家公司获融资，涉及药物类型包括创新抗体、AI药物等。#01Granite Bio获1亿美金融资关键词：抗体类药物最新融资：1亿美元A轮+B轮本轮投资机构：Versant Ventures、诺华风险基金、Forbion、赛诺菲风险投资4月24日，Granite Bio走出隐匿模式，并宣布已完成总额1亿美元的融资。这笔资金包括由创始投资方Versant Ventures与诺华风险基金（Novartis Venture Fund）领投的3000万美元A轮融资，以及由Forbion与赛诺菲风险投资（Sanofi Ventures）领投的7000万美元B轮融资。Granite Bio的管线包含两款潜在“first-in-class”抗体GRT-001与GRT-002，用于治疗多种自身免疫性疾病。GRT-001通过清除促炎性单核细胞发挥作用，这类细胞是自身免疫和炎症反应的关键驱动因素。在非人灵长类动物研究中，GRT-001能够高效且呈剂量依赖性地清除促炎性单核细胞，治疗耐受性良好，同时保留了组织驻留巨噬细胞，这些细胞对维持组织稳态至关重要。该候选药目前正在健康志愿者中开展1a期临床试验，并有望于今年晚些时候进入炎症性肠病（IBD）患者的1b期研究。#02Etiome完成5000万美元A轮融资关键词：AI药物最新融资：5000万美元A轮本轮投资机构：Flagship Pioneering4月24日，Etiome宣布完成5000万美元融资。Etiome在过去四年里构建了一个平台，旨在绘制疾病随时间推移的进展情况，追踪关键分子和生物标志物，不仅识别潜在的药物靶点，还确定这些药物应在何时使用以阻止疾病。这笔5000万美元的启动资金将支持Etiome开发公司的“预防性药物”，这些药物最初将重点关注代谢性、神经退行性、自身免疫性疾病以及癌症。Etiome首先在脂肪性肝病代谢功能障碍相关脂肪性肝炎（MASH）上进行研究，结合不同阶段患者的数据，构建出“疾病进展中的分子变化动画”。#03Avidicure完成5000万美元种子轮融资关键词：多功能抗体最新融资：5000万美元种子轮本轮投资机构：BOM、BioGeneration Ventures、Curie Capital、EQT Life Sciences、Kurma Partners、V-Bio Ventures4月24日，Avidicure宣布以5000万美元的种子融资启动。Avidicure正在开发双激动、多功能和亲和力工程化抗体AVC-Boosters，能够安全地提供针对性强的癌症单药疗法。AVC-Boosters可以激发强大且协调的免疫反应，充分利用先天和适应性免疫系统。Avidicure完全自主的平台利用了数十年的抗体工程和计算机设计能力，以及免疫学专业知识。通过AVC-Booster的即插即用功能，可以开发多种产品。Avidicure的主导产品AVC-S-101是一种针对TROP2的增强剂，正在开发用于非小细胞肺癌及多种其他适应症。#04舜景医药获3亿元增资关键词：抗体药物最新融资：3亿元未知轮本轮投资机构：丽水巧达、创景康润、创景舜泽、松禾基金、热景生物、达晨财智4月23日，热景生物公布总金额为3亿元的增资。舜景医药是由热景生物孵化的一家创新驱动型生物医药技术公司，致力于原创性抗体药物的发现、开发以及商业化。凭借卓越的科研和创新药物开发能力和AI技术赋能，已经构建了慢性疾病系列创新抗体药物布局，涉及心脑血管、肿瘤、神经退行性等多种疾病的治疗。其中，研发进度最快的一款用于治疗急性心肌梗死的全球首创抗体药物SGC001，已先后获得美国FDA及国家药品监督管理局的临床试验申请（IND）批准，并于2025年3月获得美国FDA授予的快速通道认证，目前正在全国多个中心开展1b期临床试验。#05泽安生物医药完成4000万美元A+轮融资关键词：肿瘤免疫疗法最新融资：4000万美元A+轮本轮投资机构：万物资本、五源资本、滤泡性淋巴瘤创新研究所、独秀资本、蓝驰创投、高瓴创投、龙磐资本4月24日，泽安生物医药（LTZ Therapeutics）宣布超额完成A+轮融资，成功募集4000万美元。泽安生物医药聚焦癌症、自身免疫性疾病等重大疾病领域的未满足临床需求，致力于研发以“髓系细胞衔接器”技术平台（Myeloid Engager Platform）为基础的新型免疫疗法。该公司的研发策略深度融合“反向转化科学”（Reverse Translational Science）与对“肿瘤微环境”（TME）生物学（特别是髓系细胞生物学）的深刻理解。本轮新募资金将主要用于支持泽安生物医药首款候选药物LTZ-301的1期临床研究，推动第二款候选药物LTZ-232针对泛实体瘤适应症的IND申报准备工作，同时，助力其他早期项目的研发和全球团队的扩展。读者们请星标⭐创鉴汇，第一时间收到推送免责声明：本文仅作信息交流之目的，文中观点不代表药明康德立场，亦不代表药明康德支持或反对文中观点。本文也不是治疗方案推荐。如需获得治疗方案指导，请前往正规医院就诊。版权说明：欢迎个人转发至朋友圈，谢绝媒体或机构未经授权以任何形式转发/复制至其他平台。转发授权请在「创鉴汇」微信公众号留言联系我们。更多数据内容推荐点击“在看”，分享创鉴汇健康新动态

Plus, news about Novo Holdings, Bioxodes and Tempus AI: Dutch biotech raises $50M in seed funding: Avidicure, which is developing avidity engineered antibodies for cancer, said it plans to use the funding to move its lead product, AVC-S-101, into the clinic for solid tumors. The round, announced Wednesday, was led by EQT Life Sciences. Other investors include Kurma Partners and BioGeneration Ventures. — Jaimy Lee Flagship Pioneering launches new company: The company is called Etiome, which is working on an AI platform to forecast disease progression in patients. Flagship is also giving Etiome $50 million. — Anna Brown Novo Holdings, Danish bank fund VC: Novo Holdings and the Export and Investment Fund of Denmark are investing €48 million into HealthCap IX, a Swedish venture fund. HealthCap plans to use the funding to open an office at the BioInnovation Institute in Copenhagen as well as invest in start-ups. — Anna Brown Bioxodes touts interim Phase 2a data: The company’s tick-derived program, called BIOX-101, succeeded on the primary and secondary endpoints in a study for intracerebral hemorrhagic stroke. It’s now trying to fund a Series B, build up manufacturing capacity and launch a Phase 2b study, with a goal of starting the trial in the first half of 2027. — Max Gelman Tempus AI inks expanded deals with AstraZeneca, Pathos: The companies plan to develop a multimodal foundation model in oncology. In return, Tempus is getting $200 million in fees. The company first linked up with AstraZeneca in 2021. — Jaimy Lee

Boehringer Ingelheim has inked a research collaboration with Tessellate Bio to develop precision medicines for cancers that maintain telomere length to survive and grow. The Amsterdam-based biotech could get more than €500 million ($573 million) in upfront license fees, research funding and milestones, according to a Wednesday release. The partners will focus on advancing oral drugs for ALT (alternative lengthening of telomeres) positive cancers. Telomeres act as protective seals at the end of chromosomes. They get shorter with each round of cell division and eventually reach critically short lengths, causing cells to stop dividing or die, Tessellate CEO Andree Blaukat told Endpoints News in an interview. But ALT positive cancers can keep telomere length, which means the cells continue surviving and dividing. Tessellate said it has discovery-stage candidates that block an unnamed target associated with the “uncontrolled growth” of ALT positive tumor cells. The biotech will now work exclusively with Boehringer on these programs. The candidates trigger DNA damage and cancer cell death while sparing healthy tissue, according to the biotech. The tie-up marks Tessellate’s first partnership with a biopharma company. The biotech previously teamed up with research institutes CMRI and Omico in September 2024 to take a closer look at the prevalence of ALT across tumor types and the genetic influences involved. Around 10% to 15% of all cancers rely on the ALT maintenance mechanism and there’s a “particularly high prevalence” for mesenchymal tumors and brain cancers, Blaukat said. More common cancers — such as breast, colorectal and lung — are ALT positive in the range of 5% or less, he added. Tessellate is developing a companion diagnostic device to help identify patients with more common cancers who may benefit from a treatment that addresses the ALT mechanism. Elsewhere, the biotech’s lead in-house program targets cancers with loss of function in the retinoblastoma 1 gene, which is responsible for tumor suppression. Tessellate said this feature affects between 80% and 100% of small cell lung cancer cases and more than 40% of triple-negative breast cancer cases. The company emerged from stealth in October 2023 with €8 million in seed funding from BioGeneration Ventures and Forbion. It has labs in Stevenage, UK, alongside its Dutch base. Meanwhile, Boehringer has been bulking up its oncology pipeline in recent years. In July 2024, the German drugmaker bought Nerio Therapeutics in a deal featuring $1.3 billion in biobucks. Nerio is developing small molecule drugs that inhibit PTPN1 and PTPN2. All in all, Boehringer has acquired more than six cancer biotechs since 2019.