Foundation Medicine Inc. (FMI) is interested in studying the concordance of genomic alterations between primary and/or metastatic surgical biopsies, and circulating tumor DNA (ctDNA) within different solid tumor types and has been developing an assay in order to do so.

开始日期2014-11-01

申办/合作机构

Foundation Medicine, Inc.

[+19]

100 项与 Quincy Medical Group 相关的临床结果

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0 项与 Quincy Medical Group 相关的专利（医药）

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项与 Quincy Medical Group 相关的文献（医药）

2025-09-01·Interventional pain medicine

Assessment of real-world, prospective outcomes in patients treated with cervical radiofrequency ablation for chronic pain (RAPID)

Article

作者: Danko, Michael ; Donck, Ella Ver ; Sachdeva, Harsh ; Atallah, Joseph ; Pan, Ann ; Haas, Sherri ; Singh, Albert ; Shah, Binit ; Goldberg, Edward ; Iqbal, Maaz ; Halperin, Daniel S ; Holt, Bradley ; Liebrand, Bart ; Shaw, Erik ; Sekhar, Rajat ; Provenzano, David A

Introduction:

Cervical facet joint syndrome (CFJS) is a common cause of chronic neck pain. While numerous studies have demonstrated the effectiveness of radiofrequency ablation (RFA) for facetogenic pain, its use in treating CFJS remains a subject of ongoing debate.

Objective:

Here, we sought to evaluate real-world clinical outcomes in cervical RFA-treated patients with chronic cervical facetogenic pain.

Methods:

The RAPID study (Clinicaltrials.gov identifier: NCT04673032) is an international, multicenter, prospective study of patients using a commercially-available radiofrequency ablation system for the treatment of chronic pain, provided per standard of care. Patients were monitored at study follow-up visits (1-, 3-. 6-, 12-, and 24-months post-index procedure). Key clinical endpoint measures collected and evaluated include numeric pain rating scale (NPRS), Oswestry Disability Index (functional disability, ODI), EQ-5D-5L (quality-of-life), and Patient Global Impression of Change (PGIC).

Results:

A total of 56 patients were enrolled in this cervical facetogenic pain cohort. At both 6 (n = 49) and 12 months (n = 40), mean NPRS pain scores significantly decreased from a baseline of 6.0 ± 1.9 to 3.3 ± 2.8 and 3.3 ± 2.2, respectively (p < 0.0001). Oswestry Disability Index (ODI) scores also improved, dropping by 7.9- and 9.7-points from a baseline of 32.7 (p < 0.0001). Treatment response rates (≥50 % pain relief) were 81 % at 1 month and 80 % at 12 months. Improvements in quality-of-life (EQ-5D-5L) and self-reported change (PGIC) were also consistently observed.

Conclusions:

The cervical RFA cohort in the RAPID study demonstrated consistent, clinically meaningful improvements in pain, function, quality-of-life, and treatment satisfaction across all follow-up visits, underscoring the real-world effectiveness of RFA for appropriately selected patients with cervical facetogenic pain.

2025-07-01·MAYO CLINIC PROCEEDINGS

Colonic Angiodysplasia

Article

作者: Mikolajczyk, Adam E ; Gianarakis, Michael ; Ghoulam, Elie

2025-06-01·Interventional Pain Medicine

Assessment of real-world, prospective outcomes in patients treated with lumbar radiofrequency ablation for chronic pain (RAPID)

Article

作者: Danko, Michael ; Donck, Ella Ver ; Atallah, Joseph ; Sachdeva, Harsh ; Pan, Ann ; Haas, Sherri ; Singh, Albert ; Shah, Binit ; Iqbal, Maaz ; Goldberg, Edward ; Holt, Bradley ; Halperin, Daniel S ; Shaw, Erik ; Sekhar, Rajat ; Provenzano, David A

Background:

Lumbar facet joint syndrome (LFJS) is one of most common forms of chronic low back pain. Despite several decades of real-world use and a plethora of published studies, debate still exists regarding the effectiveness of Radiofrequency Ablation (RFA) as a therapy in LFJS-diagnosed patients.

Objective:

Here, we sought to evaluate real-world clinical outcomes in RFA-treated patients with chronic lumbar facetogenic pain participating in one of the largest studies of its kind published to date.

Methods:

The RAPID study (Clinicaltrials.gov identifier: NCT04673032) is an international, multicenter, prospective study of patients using a commercially-available radiofrequency ablation system for the treatment of chronic pain, provided per standard of care. Patients were assessed at pre-specified study follow-up visits (1-, 3-. 6-, 12-, and 24-months post-index procedure). Key clinical endpoint measures collected and evaluated include NRS (pain score), Oswestry Disability Index (functional disability, ODI), EQ-5D-5L (quality-of-life), and Patient Global Impression of Change (PGIC).

Results:

To date, 193 patients have been enrolled in this lumbar facetogenic pain patient cohort. Evaluation of pain relief amongst patients assessed out to 24-months demonstrated a mean NRS score of 3.4 (baseline NRS: 6.6, p < 0.0001). Consistent functional improvement out to 24-months was observed per an 8.6-point mean ODI score reduction (baseline ODI: 38.0, p < 0.0001). Following RFA treatment at 1-month and out to 24-months, 77.0% and 79.0% of patients were observed to be treatment responders (i.e., ≥50% pain relief), respectively. Enhanced levels in measures of quality-of-life (EQ-5D-5L) and self-reported health-related change (PGIC) were also consistently noted.

Conclusions:

Clinically meaningful and durable improvements in pain relief, functional disability, quality-of-life and treatment satisfaction were observed across all RAPID study follow-up visits. The results of the RAPID study provide for the potential clinical outcomes amongst selected patients with lumbar facetogenic pain within the real-world clinical setting.

项与 Quincy Medical Group 相关的新闻（医药）

2021-05-26

·Beckers Hospital Review

Illinois rejects Quincy Medical Group's plan to build $61M hospital

An Illinois review board May 26 denied Quincy (Ill.) Medical Group's proposal to build a $61 million hospital, according to local news station WHIG. The Illinois Health Facilities and Services Review Board voted 4-2 to reject the proposal, citing concerns about duplication of services. Quincy Medical Group was seeking approval to build a 25-bed, physician-led hospital next to the medical group's cancer institute and surgery center in Quincy. The proposal called for building a 10-bay emergency department, three operating rooms and one procedure room. Despite the rejection, Quincy Medical Group has the option to present the project to the board again with new details and information. "We appreciated the opportunity to present our proposed project today," Quincy Medical Center said in a prepared statement. "Two members of the CON Board called the QMG Hospital project a 'breath of fresh air' and we couldn’t agree more. Limited healthcare options have resulted in Quincy-area residents paying disproportionately high rates for healthcare. We remain steadfast in our commitment to this project and our commitment to drive down healthcare costs in our community and make the very best in patient care accessible to all. We respect the HFSRB's feedback on our project and look forward to providing additional information."

2021-05-05

·Beckers Hospital Review

Blessing CFO says new hospital in community will cut revenue, but Quincy Medical disagrees

Blessing CFO says new hospital in community will cut revenue, but Quincy Medical disagrees The CFO of Blessing Health System in Quincy, Ill., said the opening of a new 25-bed hospital in the community will lead to revenue losses, according to a May 4 report in the Herald-Whig. Quincy Medical Group, which is proposing the hospital, disagrees, and said the project will improve care coordination and clinical outcomes in the area. In a letter to the Illinois Health Facilities and Services Review Board, Patrick Gerveler, CFO of Blessing Health, said Quincy Medical Group's proposed hospital would strip his facility of its Sole Community status. The status is designated by CMS for hospitals that are geographically isolated. Losing the status would result in a yearly revenue loss of $6.9 million because of lower Medicare rates, Mr. Gerveler wrote in the letter. In addition to Mr. Gerveler's letter, representatives from Blessing and a management consulting firm working for the health system argued Quincy Medical Group's application for the new hospital doesn't include pricing or data transparency, according to the Herald-Whig. However, supporters of the new $61 million hospital said it would increase competition and economic development in the area, according to the report. In an op-ed authored by Todd Petty, MD, chairman of the Quincy Medical Group board of directors, Dr. Petty wrote: "Since announcing plans for QMG Hospital — a state-of-the-art, 25 med-surg bed hospital designed to improve outcomes while reducing costs — we have received overwhelming support from patients, community leaders and employers. We planned the new facility in response to input from area residents regarding hospital-based care, and we are humbled by the hundreds of patients who have told the certificate of need board they want and need this hospital." A study conducted by Guidehouse for Blessing found the health system's commercial rates were 157 percent of the median market for inpatient services and 150 percent of the median market for outpatient services, according to an April 22 report from the Herald-Whig. The board has yet to approve the proposed hospital. Read more here. Editor's note: This article was updated to include more information. © Copyright ASC COMMUNICATIONS 2021. Interested in LINKING to or REPRINTING this content? View our policies by clicking here.

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100 项与 Quincy Medical Group 相关的转化医学

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