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更新于：2026-03-19
Waters Corp.
更新于：2026-03-19
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NCT03432429
Rapid Evaporative Ionisation Mass Spectrometry for Examination of Circumferential Surgical Excision Margins
100 项与 Waters Corp. 相关的临床结果
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2026-03-04JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
A Novel Compact Multi-Reflecting Time-of-Flight Mass Spectrometer
Article
作者: Gethings, Lee A. ; Tonge, Robert P. ; Verenchikov, Anatoly N. ; Vorobyev, Aleksey V. ; Wildgoose, Jason ; Makarov, Vasily V. ; Johnson, William J. ; Kirillov, Sergey N. ; Daly, Matthew E. ; Langridge, James I.
Mass spectrometry is an indispensable tool for the rapid and in-depth analysis of complex mixtures across diverse biologically important fields including metabolomics, lipidomics, and proteomics. These applications demand high speed instruments with subppm mass measurement accuracy over a wide dynamic range of sample concentrations. Here, we introduce an liquid chromatography-mass spectrometry/MS (LC-MS/MS) quadrupole time-of-flight mass spectrometer featuring a novel collision cell, a high dynamic range detector, and a compact multireflecting orthogonal time-of-flight analyzer. This innovative instrument achieves high analytical performance, acquiring full mass range spectra at 100,000 Full Width Half Maximum (FWHM) resolution up to 100 spectra/s acquisition speed. The instrument achieves excellent linearity within a dynamic range of 105, with a correlation coefficient R2 = 0.984. The speed, resolution and dynamic range are in excellent balance as demonstrated by the analysis of isotopically labeled lipids in human blood plasma.
2026-03-01JOURNAL OF CHROMATOGRAPHY A
Molecular dynamics simulations of mixed-mode chromatography: Generation and solvation of a silica-based, reversed-phase/anion-exchange stationary phase
Article
作者: Wyndham, Kevin D ; Steinhoff, Andreas ; Tallarek, Ulrich ; Höltzel, Alexandra ; Gritti, Fabrice ; Frerichs, Daniel ; Walter, Thomas H
As a first step towards predicting retention for mixed-mode liquid chromatography (MMLC) separations of small, hydrophilic, ionizable analytes, we created a slit-pore model of a silica-based, endcapped, reversed-phase/anion-exchange (RP/AEX) stationary phase and performed molecular dynamics simulations of its solvation by a water‒acetonitrile (W‒ACN) mobile phase under conditions where the AEX function is neutral or charged. In the latter case, sodium and chloride ions were added as co-ions and counterions, respectively, to the 60/40 (v/v) W/ACN mobile phase. The silica surface functionalization, which modeled existing column technology, yielded a unique surface topology, where bonded-phase islands formed by octadecylsilyl chains around a central tertiary alkylamine group are interspersed with hydroxylated silica patches that are exposed to the mobile phase. The two MMLC systems were analyzed regarding the solvent density, structure, and orientation with respect to the density distribution of hydrophobic and hydrophilic bonded-phase elements (alkyl groups and nitrogen atoms, respectively) at different distances from the silica surface. Effects originating from the surface functionalization were captured by comparison with a conventional RPLC stationary phase, whereas effects originating from the presence of charge were quantified by comparing the two simulated MMLC systems (neutral vs. charged surface). The analysis of ion density distributions and ion contact profiles, in particular, suggested that the surface topology of the MMLC stationary phase shields the AEX function from contact with hydrophilic counterions and favors the accumulation of analyte compounds with both hydrophobic and hydrophilic structural elements.
2026-02-02Thermal Conductivity
Linear Thermal Expansion Characteristics of AXM-5Q Graphite
作者: Apostolescu, D. E. ; Gaal, P. S. ; Ciuca, J. L.
A general historical review of previously published data on AXM-5Q graphite is provided.This material is widely used for reference to calibrate high temperature push-rod dilatometers, using "best available data" from literature.Previously not seen variations possibly caused by d. differences or processing changes are discussed.
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