Technol. and prescription for preparation of Xiangyungantai Granules were explored by orthogonal design, with granule yield as main index. In the prescription, the mass ratio of Lentinus edodes polysaccharide lentinan powder to Coriolus versicolor polysaccharide powder was 3:2, and the optimal conditions for high-speed wet granulation method were as follows: the amount of main ingredients accounting for 60% of the prescription, the amount of 70% ethanol 25 mL/100 g, and stirring time 2 min. In the confirmation test, the disintegration time was 41 min. The preparation method is scientific and reasonable.