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疾病领域	数量

血液及淋巴系统疾病	1
免疫系统疾病	1
肿瘤	1

排名前五的药物类型	数量

自体CAR-T	1

排名前五的靶点	数量

CD19(B淋巴细胞抗原CD19)	1

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1

项与 Takara Bio Inc. 相关的药物

TBI-2001

靶点

CD19

作用机制

CD19抑制剂 [+2]

在研机构

Takara Bio Inc.

原研机构

Takara Bio, Inc.

在研适应症

CD19阳性B细胞淋巴瘤 [+2]

非在研适应症-

最高研发阶段临床1期

首次获批国家/地区-

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100 项与 Takara Bio Inc. 相关的临床结果

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0 项与 Takara Bio Inc. 相关的专利（医药）

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75

项与 Takara Bio Inc. 相关的文献（医药）

2024-03-01·Neuroscience Letters

“Evaluation of neprilysin activity in Adipose-Derived stem cells from Alzheimer's disease patients”

Article

作者: Ideno, Mitsuko ; Yamagishi, Hisakazu ; Komori, Naoyuki ; Shigematsu, Kazuo

INTRODUCTIONThe antibody drugs targeting β-amyloid in Alzheimer's disease pose risks of inflammation and vascular damage. It is known that neprilysin, an endogenous enzyme responsible for β-amyloid degradation, is reduced in areas with β-amyloid deposition. Supplementation of neprilysin could potentially contribute to Alzheimer's disease treatment. When considering the use of adipose tissue-derived stem cells (ADSCs) for Alzheimer's disease therapy, it is crucial to ensure that Alzheimer's disease patient-derived ADSCs maintain neprilysin activity. If so, the use of autologous ADSCs may lead to a treatment with minimal risks of rejection or infection. Therefore, we investigated the neprilysin activity in Alzheimer's disease patient-derived adipose tissue-derived stem cells to assess their potential in Alzheimer's disease treatment.METHODSFive Alzheimer's disease patients (MSC1-5) and two Chronic Obstructive Pulmonary Disease (COPD) patients (MSC6-7) were enrolled. ADSCs were cultured for 6 days with varying seeding densities. On the 3rd day, the medium was replaced, and on the 6th day, ADSCs were harvested. Cells were stained for PE-Cy7 Mouse IgG1 κ Isotype control and PE-Cy Mouse Anti-Human CD10, and CD10 expression was assessed by flow cytometry. Ethical approval and informed consent were obtained.RESULTSNeprilysin activity, crucial for β-amyloid degradation, was assessed in ADSCs. Positivity rates for CD10 expression in ADSCs from Alzheimer's patients were consistently high: 99.6%, 99.5%, 99.9%, 99.3%, 99.8%, and 100.0%. Control ADSCs from COPD patients (MSC6-7) exhibited comparable positivity rates. Flow cytometry plots for all seven cases are presented in Figures 1-7.DISCUSSIONThis study confirms the presence and maintenance of neprilysin activity in ADSCs from Alzheimer's disease patients. The high positivity rates for CD10 expression in these cells suggest that neprilysin, a key enzyme in β-amyloid degradation, remains active. The implications are significant, as ADSCs offer immune-compatible and low infection risk advantages. The study underscores the potential of autologous ADSCs as a therapeutic approach in Alzheimer's disease. Their ability to naturally harbor neprilysin activity, coupled with their safety profile, makes them a promising candidate for further exploration. While acknowledging the need for larger, more diverse cohorts and long-term studies, these findings contribute to the growing body of evidence supporting the development of stem cell-based interventions in Alzheimer's disease treatment.

2019-01-01·Journal of Clinical Biochemistry and Nutrition4区 · 医学

Gut microbiota differences in elderly subjects between rural city Kyotango and urban city Kyoto: an age-gender-matched study

4区 · 医学

Article

作者: Inoue, Ryo ; Itoh, Yoshito ; Okuda, Kayo ; Matoba, Satoaki ; Mizushima, Katsura ; Oda, Yohei ; Naito, Yuji ; Maruyama, Naoki ; Adachi, Atsuo ; Tsujimoto, Yoshimasa ; Tsuchiya, Saeko ; Takagi, Tomohisa ; Kashiwagi, Saori

Several outcomes have been reported on the role of gut microbiota in health promotion and disease prevention. Kyotango, one of the longevity areas with various centenarians, is a provincial city located in the northern part of Kyoto Prefecture in Japan. To understand the relationship between gut microbiota and urbanization, we compared the diversity, abundance, and function of gut microbiota in older healthy subjects between Kyotango and Kyoto cities; Kyoto is an urban city located in the southern part of Kyoto Prefecture. In total, 51 subjects at Kyotango and 51 subjects at Kyoto matched by age and gender were recruited, and their fecal samples were obtained to analyze the gut microbiota using 16S rRNA gene sequencing. Principal coordinate analysis for β-diversity revealed significant differences in the gut microbiota between two cities. In contrast, the analysis of α-diversity revealed no significant differences between the groups. On comparison at the phylum levels, the abundance of Firmicutes was decreased with the urbanization, whereas that of Proteobacteria and Bacteroidetes increased. On comparison at the genus levels, with urbanization, a significant decrease was observed in Lachnospiraceae families including genus Roseburia and Coprococcus, and significant increases was observed in Bacteroides, Oscillospira, Parabacteroides, and Ruminococcus. The most markedly increased functional pathway with urbanization was lipopolysaccharide biosynthesis proteins and lipopolysaccharide biosynthesis, and decreased pathway was transporters and ABC transporters. In conclusion, the present findings indicate significant differences in the gut microbiota between the provincial city and urban cities at Kyoto Prefecture. These alterations in the microbiota may provide new insights to consider the relationship between longevity and gut microbiota.

2018-01-01·Journal of Clinical Biochemistry and Nutrition4区 · 医学

The influence of long-term use of proton pump inhibitors on the gut microbiota: an age-sex-matched case-control study

4区 · 医学

Article

作者: Yoshida, Naohisa ; Naito, Yuji ; Dohi, Osamu ; Ishikawa, Takeshi ; Itoh, Yoshito ; Konishi, Hideyuki ; Okayama, Tetsuya ; Ohnogi, Hiromu ; Tsujimoto, Yoshimasa ; Mizushima, Katsura ; Kashiwagi, Saori ; Kamada, Kazuhiro ; Handa, Osamu ; Okuda, Kayo ; Uchiyama, Kazuhiko ; Takagi, Tomohisa ; Tsuchiya, Saeko ; Inoue, Ryo

Proton pump inhibitors (PPIs) are widely used to treat gastro-esophageal reflux and prevent gastric ulcers, and have been considered as low risk. However, recent studies have identified possible associations between PPI use and gut microbiota, suggesting that PPIs use increases the risk of enteric infections, including Clostridium difficile infection. To investigate gut microbiota in Japanese PPIs users, we conducted 16S metagenomics analysis of fecal samples collected from PPI users and healthy adults. In total, 36 PPI users and 36 PPI non-users (as control subjects) matched by age and sex were recruited and fecal samples were obtained to analyze the gut microbiome using 16S rRNA gene sequencing. There were significant differences in the microbial structure between PPI non-users and PPI users. In contrast, the analysis of α-diversity revealed no significant differences between PPI non-users and PPI users. When comparing in genus level between these two groups, the genera Streptococcus was significantly abundant and the genera Faecalibacterium was significantly decreased in PPI users. Our findings indicate a probable association between PPI use and the alternation of microbiota. These alterations might provide a mechanism by which PPIs predispose enteric infection such as Clostridium difficile infection.

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