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项与 Antibiotic Research Institute 相关的临床试验

NCT05743816

/ RecruitingN/AIIT

Neonatal Antimicrobial Resistance and Outcome (neoAMRO)

This is a multicentre observational study involving NNUs across the UK. Study personnel (Neonatologists and research Nurses) from these NNUs will identify eligible babies in whom a positive culture has been obtained.
This study will help identify the infections leading to death in babies on UK neonatal units, define the clinical characteristics of babies dying from infections, and describe the management of babies dying from infections with a specific focus in their antimicrobial treatment.

开始日期2019-07-30

申办/合作机构

St. George's University of London

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100 项与 Antibiotic Research Institute 相关的临床结果

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0 项与 Antibiotic Research Institute 相关的专利（医药）

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13

项与 Antibiotic Research Institute 相关的文献（医药）

1999-01-01·Synthetic Communications

A New Synthesis of Roxatidine Acetate

作者: Angelova, Nely ; Mechkarova, Pepa ; Krikorian, Dikran ; Parushev, Stoyan ; Penkov, Miho ; Schunack, Walter ; Vlahov, Radoslav ; Tarpanov, Velichko

A new four-step synthesis of N-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}acetoxyacetamide hydrochloride has been performed.The key aralkyl ether was synthesized in high yield under moderate conditions.A suitable scaling up permits a bulky production of the drug in 98.5% purity.

1964-01-01·Continuous Cultivation of Microorganisms

CHLORTETRACYCLINE AND PIGMENT FORMATION BY STREPTOMYCES AUREOFACIENS IN CONTINUOUS CULTURE

作者: Sikyta, B. ; Slezak, J.

cf. CA 55, 19130e.In a continuous culture of S. aureofaciens in a synthetic medium using sucrose as the limiting substrate, changes in dilution rate result in significant differences in chlortetracycline and pigment formation.In the steady state, both chlortetracycline and the pigments are synthesized only at dilution rates >0.05 hr.^-1 and are not formed at dilution rates <0.05 hr.^-1An explanation was sought for these observations.It was found that the introduction of nonpigmented mycelium into a continuous culture never leads to the production of pigments in the medium or to mycelium pigmentation.When pigmented mycelium from a batch culture was used, the pigment was invariably released into the medium unless sucrose was excluded.The results showed that the loss of ability to synthesize pigments and chlortetracycline is inherent in the cells and unaffected by changes in the medium composition during batch cultivation.This loss is a result of long-term cultivation under conditions prevailing during continuous fermentation at low dilution rates; it is impossible to maintain these conditions in batch culture for longer periods of time.The reason for the partial or complete loss of ability of the strain to produce chlortetracycline and pigments (in continuous culture at low dilution rates) is the selection of nonpigmented part of a heterogeneous population with suppression of growth of the pigmented part.When discussing the term steadystate, the concentration of the organism and basic nutrients may remain unchanged while other important variables do change.Therefore, it is important to state the criterion for the definition of the steady-state.

Biokhimiya (Moscow)

The mode of action of antifungal polyenic antibiotics on alcoholic fermentation in yeast

作者: Litvinova, V. N. ; Klimov, A. N.

Levorin (0.005 mg./ml. or more) or nystatin (0.001 mg./ml. or more) inhibited alc. fermentation in intact cells and in diluted extracts of Saccharomyces cerevisiae.In isolated systems levorin inhibited the activities of yeast alc. dehydrogenase and triosephosphate dehydrogenase.The ineffectiveness of levorin in concentrated yeast extracts was due to the high levels of inorganic phosphate and alc. fermentation enzymes and coenzymes.17 references.

100 项与 Antibiotic Research Institute 相关的药物交易

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100 项与 Antibiotic Research Institute 相关的转化医学

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