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National Center for Parasitology, Entomology and Malaria Control

更新于：2024-11-01

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项与 National Center for Parasitology, Entomology and Malaria Control 相关的临床试验

NCT04848688 / Completed临床3期IIT

Efficacy and Safety of Moxidectin in Comparison to Ivermectin Against Strongyloides Stercoralis Infection in Adults: a Randomized Controlled Non-inferiority Trial

The study is an extension to the study StrongMoxi NCT04056325 and entails modifications based on the outcome of NCT04056325 part A.
The study is a phase 3, double-blinded and randomized clinical trial conducted in Cambodia. It aims at providing evidence on efficacy, safety and pharmacokinetic measures of 8 mg of moxidectin compared to 200 μg/kg ivermectin in adults infected with S. stercoralis. The efficacy of the treatment will be assessed by collecting three stool samples once per-treatment and once 21-28 days post-treatment. The stool samples will be analyzed by a quantitative duplicate Baermann assay.

开始日期2022-02-05

申办/合作机构

Swiss Tropical & Public Health Institute

[+1]

NCT05117567 / Unknown statusN/AIIT

A Personal Protection Package for Reducing Malaria Transmission in Forest-going Mobile and Migrant Populations in Lao PDR and Cambodia: A Stepped-wedge Trial With Nested Mixed-methods Study

This stepped-wedge cluster-randomized controlled trial with nested mixed methods study will assess the effectiveness, acceptability, feasibility and cost-effectiveness of a personal protection package to reduce malaria transmission among mobile and migrant populations (MMPs) and the general population in their residing villages in Lao People's Democratic Republic (PDR) and Cambodia.

开始日期2021-12-01

申办/合作机构

The Macfarlane Burnet Institute For Medical Research & Public

[+2]

NCT04411836 / Completed临床3期IIT

Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and Primaquine - a Randomized Controlled Trial in P. Vivax Patients

Health care facility based, randomized, controlled, open label, superiority trial with 3 arms

开始日期2021-04-25

申办/合作机构

Menzies School of Health Research

[+5]

100 项与 National Center for Parasitology, Entomology and Malaria Control 相关的临床结果

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0 项与 National Center for Parasitology, Entomology and Malaria Control 相关的专利（医药）

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项与 National Center for Parasitology, Entomology and Malaria Control 相关的文献（医药）

2022-09-01·Food and Waterborne Parasitology

Human trichinellosis in Southeast Asia, 2001–2021

Article

作者: Khieu, Virak ; Caron, Yannick ; Bory, Sotharith ; Yera, Hélène

To present the situation of human trichinellosis in Southeast Asia in the last 20th years we analyzed outbreak data and seroprevalence studies from 2001 to 2021 for this region. We queried PubMed (https://pubmed.ncbi.nlm.nih.gov) using keywords "Trichinella", "human" and "Southeast Asia". In addition, we described Trichinella species circulating in this region. In Southeast Asia, in communities eating pork, several cultural factors play important roles in the transmission of Trichinella to humans. The seroprevalences of Trichinella infection in humans are known for Laos and Vietnam to be 0-10.5% in some villages. Also, in Cambodia, Laos, Malaysia, Thailand and Vietnam relatively few human outbreaks (13) and cases (1604) have been recorded during the last 21st years. Their associated mortality rates were low (0.75%). Trichinella spiralis and T. papuae were transmitted after consumption of raw or undercooked pork from domesticated and wild pigs. T. papuae transmission was related to consumption of wild boar. In this region, trichinellosis was frequently subclinical and clinical or severe cases were sporadic and occurred more in male patients. Nevertheless, it is likely that trichinellosis is widely under-diagnosed and is an endemic disease.

2019-06-05·The American Journal of Tropical Medicine and Hygiene4区 · 医学

A Critical Enquiry into Variability of Insecticidal Net Use in Cambodia: Implications for Assessing Appropriateness of Malaria Elimination Interventions

4区 · 医学

Article

作者: Gerrets, René ; Peeters Grietens, Koen ; Bannister-Tyrrell, Melanie ; Uk, Sambunny ; Gryseels, Charlotte ; Suon, Sokha ; Set, Srun

Distributing long-lasting insecticidal nets (LLINs) to individuals living in malaria-endemic regions is a cornerstone of global malaria control. National malaria control programs aim to achieve “universal coverage” of at-risk populations to reach LLINs’ full potential to reduce malaria, progress of which is then measured by indicators constructed from standardized questionnaires. Through an exploration of variability in LLIN use in Cambodia, we argue that indicators of universal coverage of LLINs are not sufficiently commensurate with the realities they are intended to measure, limiting the suitability of the data to serve program and policy purposes in a malaria elimination era. Reflecting on the various sources of variability in LLIN use, we apply and extend the concept of “appropriateness” as a third prong to the widely used “efficacy” and “effectiveness” criteria for evaluating LLINs as a tool for malaria prevention. Describing first the different dimensions of the intervention and the sociocultural context separately, we will further show how the variability underlying both is affected and induced by inappropriate aspects of the intervention and the measurements of its impact. We consider the gap between “net use” and the numerical representations of such local net use justifies further exploration of potential strategies to improve LLIN use in subgroups where persisting malaria transmission clusters.

2018-12-01·Infectious Diseases of Poverty1区 · 医学

Assessment of net lending strategy to better reach mobile and migrant populations in malaria endemic areas of Cambodia

1区 · 医学

ArticleOA

作者: Heng, Sopheab ; Ek, Sovann ; Gopinath, Deyer ; Rekol, Huy ; Bun, Sreng ; Sokomar, Nguon ; Say, Chy ; Ty, Kheang Soy ; Lek, Dysoley

BACKGROUNDIn Cambodia, internal migration involves migrants moving from non-malaria endemic areas to malaria endemic areas and vice versa. The majority of them work in farms or forests with various malaria transmission levels. In Cambodia, as one of the national approaches to ensure LLIN accessibility and use among mobile and migrant populations (MMPs), a lending scheme of long lasting insecticide treated nets (LLINs) was initiated among farm workers. Through this net lending program, LLINs and long-lasting insecticide treated hammock nets (LLIHNs) will be distributed annually at workplace (e.g. longstanding farms, plantations, industrial sites, as identified by operational district and health center staff) on a ratio of one LLIN per one worker. The main objective of this study is to assess MMPs' accessibility to LLINs through a lending scheme with plantation owners in remote malaria endemic areas of Cambodia.METHODSThe study used a cross-sectional survey among MMPs using two-stage cluster sampling method. The sampling frame is the list of farms in the four provinces of Banteay Meanchey, Battambang, Pailin, and Pursat in western and northwestern Cambodia bordering with Thailand where the LLIN lending scheme was implemented and where an estimated 100 000 MMPs worked annually. The assessment was carried out from January to February 2013 in these four provinces. It was estimated that 768 workers would be required.RESULTSA total of 702 MMPs were interviewed. The ratio of male: female is 1:1. The age group of 21-60 was the largest accounting for 77.6%. About 91% of the MMPs stayed on the farm for less than 6 months. 93.2% of them owned either untreated or insecticide treated nets. LLINs and LLIHNs accounted for 89.5%; and 46.6% of them borrowed the nets from a lending scheme. Among those workers who have LLINs/LLIHNs, 99% slept under LLINs/LLIHNs the night before. However, only 87.4% knew that sleeping under LLINs/LLIHNs protects against malaria.CONCLUSIONSLLIN lending scheme provides an important delivery channel for a substantial percentage of net accessibility (46.6%) to the Cambodian national free-net distribution campaign in remote malaria endemic areas.

100 项与 National Center for Parasitology, Entomology and Malaria Control 相关的药物交易

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100 项与 National Center for Parasitology, Entomology and Malaria Control 相关的转化医学

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