A review. This paper discusses the clin. effectiveness and value of simeprevir and sofosbuvir for chronic hepatitis C virus infection. Hepatitis C virus is a major cause of liver failure, hepatocellular carcinoma, and liver transplantation. When treated with pegylated interferon and ribavirin patients with genotype 1 disease, clear the virus from their bloodstream and achieved a sustained virol. response that greatly reduces their risk of progressive liver disease.