AbstractBackground:Excess mortality serves as a valuable metric for evaluating the comprehensive health impact of healthcare systems worldwide during the COVID-19 pandemic, particularly affecting vulnerable populations, including cancer patients. This study aims to estimate excess mortality attributable to all causes and cause-specific mortality, including cancer, during the COVID-19 pandemic in South Korea. Methods: Monthly mortality data from January 2000 to December 2022 was obtained from Statistics Korea. Using the World Health Organization International Classification of Diseases and Related Health Problems (ICD-10), we identified deaths due to neoplasia (C00-D48), infectious diseases (A00-B99, U07.1, U07.2, U10), cardiovascular diseases (I00-I99), and respiratory diseases (J00-J98, U04). Excess mortality during 2020-2022 was calculated by subtracting the predicted monthly number of deaths from the observed deaths from January 2020 to December 2022. The predicted number of deaths in 2020-2022 was estimated by using exponential smoothing, specifically, Error-Trend-Seasonal (ETS) models based on the death in 2000-2019. AIC, BIC and Log likelihood criteria were used to evaluate the different models of ETS, which showed that (additive, additive, additive) model was the most well-fitting. Results: All-cause excess mortality was highest in March 2022, with a total of 44, 616 observed deaths (predicted deaths: 26, 874, 95% confidence interval (CI): 22, 271 - 31, 476 deaths, statistically significant). There was significant excess mortality due to infectious and parasitic diseases in every month from 2021 to 2022, peaking at March 2022 (1367.75%), which corresponded to 11, 893 observed deaths (predicted deaths: 810, 95% CI 676 - 945). The number of deaths attributable to cardiovascular or respiratory diseases was not statistical different from predicted values. Notably, excess mortality attributable to cancer was significantly associated with the COVID-19 pandemic, peaking in February 2022 at a rate exceeding 4.45%, equating to 6, 740 observed deaths (predicted deaths: 6453, 95% CI 6212 - 6704). Among those deaths, males experienced a higher excess mortality rate of 3.91%, compared to 1.74% among females. Conclusion: We observed a significant overall increase in all-cause excess mortality during 2022 in South Korea related to the COVID-19 outbreak. Although cancer deaths remained relatively stable and closely aligned with predicted values during the study period, there was 4.45% increase of cancer death in 2022 February which exceeded the upper limit of 95% CI. Our study provides valuable insights into the resilience of cancer-related mortality patterns in South Korea amidst the challenges posed by the pandemic in accessing healthcare services and medical resources.Citation Format:Linh Thi My Bui, Jinwoo Cho, Yun-Chul Hong, Yoon-Jung Choi. Estimating excess mortality due to cancer during the COVID-19 outbreak in South Korea [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 3595.

2025-03-04·Orbit

A case of necrotizing fasciitis of the orbit secondary to Aspergillus fumigatus and mixed flora

Article

作者: Radulovich, Nicholas ; Van Brummen, Alexa ; Zhang, Matthew M. ; Chambers, Christopher ; Fu, Roxana ; Mittenzwei, Rhonda ; Hojjatie, Sara L.

A 79-year-old female presented to the emergency department for sudden-onset ocular pain, edema, and erythema around her left eye. She also had a left-sided migraine and frontal fullness for 2 weeks. She had attentive care for the diagnosis of orbital cellulitis and prompt recognition of necrotizing fasciitis. Wound cultures were positive for over 5 strains of bacteria in addition to Aspergillus. In a combined effort by our institution's Ophthalmology and Otolaryngology departments, the patient was successfully treated with debridement, porcine bladder matrix, antibiotics, and antifungals. The authors describe the first reported case of eyelid and periorbital necrotizing fasciitis, caused by mixed flora and Aspergillus fumigatus, that showed promising wound healing with the outlined treatment paradigm.

2025-03-01·Journal of Neuro-Ophthalmology

A Great Conversation With Alfredo Sadun

Article

作者: Calix, Rachel A ; Digre, Kathleen B ; Park, George T

100 项与 University of Pittsburg Cancer Institute 相关的药物交易

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100 项与 University of Pittsburg Cancer Institute 相关的转化医学

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