Queen Mary's College

Nuclear factor, erythroid derived 2,-like 1 (NFE2L1), a member of the CNC-bZIP transcription factor family, is a key regulator of cellular homeostasis by influencing oxidative stress, proteasome activity, and other factors. NFE2L1 plays a dual role in tumor development and progression; the molecular mechanisms underlying these processes are partially understood and are closely associated with oxidative stress, proteasome activity, and metabolic pathways. Furthermore, NFE2L1 also plays a role in cancer therapy by primarily regulating antioxidant effects and proteasome activity. Therefore, this review synthesizes current evidence of the mechanisms and therapeutic role of NFE2L1 in cancers, and highlights critical unresolved questions to guide future research.

Sulfur dyes, a type of dye produced in large quantities is known for its depth of color.But huge quantities of sulfides, electrolytes, and inorganic salts present in effluents containing sulfur dyes cause serious problems to environment, human, and aquatic life.Hence, in this research, chitosan - sodium tripolyphosphate@TiO₂ [chitosan - TPP@TiO₂] polymeric core/shell nanoparticles were synthesized by Ionic Gelation Method and their decolorization of sulfur black dye was examinedStructural confirmation was established through XRD and HR-TEM measurements.Surface morphol. studies with elemental anal. were investigated using HR-SEM and EDS.Core/shell formation was confirmed through XPS measurements and their optical and thermal properties were explored.Sulfur black dye decolorization studies showed 88.3% decolorization within 6 min under dark conditions at ambient conditions due to the combined effects of adsorption and catalytic wet air oxidation (CWAO).The anti-bacterial and anti-fungal activities of chitosan - TPP@TiO₂ core/shell nanoparticles were analyzed.