Delving into the Latest Updates on Global University Systems BV with Synapse

概览

疾病领域	数量

肿瘤	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

ERα(雌激素受体α)	1

关联

1

项与 Global University Systems BV 相关的药物

GTx-758

靶点

ERα

作用机制

ERα激动剂

在研机构

Medical University of The Americas Ltd. [+8]

原研机构

GTx, Inc.

在研适应症

晚期前列腺癌

非在研适应症

转移性去势抵抗性前列腺癌

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与 Global University Systems BV 相关的临床结果

登录后查看更多信息

0 项与 Global University Systems BV 相关的专利（医药）

登录后查看更多信息

569

项与 Global University Systems BV 相关的文献（医药）

2025-04-01·Journal of Clinical Neuroscience

Factors associated with ICU stays after endovascular treatments for unruptured intracranial aneurysms: A review study

Review

作者: Kendall, Nicholas ; Gajjar, Aryan ; Kallmes, David F ; Derhab, Mohamed ; Ghozy, Sherief ; Cwajna, Mark ; Arumaithurai, Kogulavadanan ; Hamouda, Abdelrahman M

BACKGROUNDFor unruptured intracranial aneurysms (UIAs), conservative management is often possible. However, when direct treatment is warranted, endovascular treatments (EVTs) provide an effective minimally invasive approach. These procedures still necessitate careful patient monitoring, frequently in the Intensive Care Unit (ICU). The factors leading to ICU admission for these patients remains an area of debate.OBJECTIVEThis systematic review aims to highlight existing literature and identify gaps in understanding the factors contributing to ICU admission following EVTs for UIAs.METHODSWe utilized the Nested Knowledge Autolit semi-automated software to gather studies published before April 2024. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and included studies that met predetermined population, intervention, control, and outcomes (PICO) criteria. Statistical analysis was performed using R software.RESULTSWe retrieved 181 studies and 9 met our inclusion criteria. There was significant variability across these studies on what factors they reported. Across included studies there were 8,189 patients, with 5,620 being placed in the ICU following EVTs for UIAs. Analysis revealed that anterior aneurysm location, aneurysm-related symptoms, and procedure length were significant factors associated with ICU admission. The overall ICU admission rate was approximately 24.61 per 100 patients.CONCLUSIONThis review underscores the need for further research to understand the factors we found associated with ICU admission following EVTs for UIAs. Additional studies are needed that use a standardized approach to collect data on patient demographics, aneurysm characteristics, procedural details, and postoperative outcomes. Such studies will allow for concrete recommendations to be made on ICU needs and prognostic calculators to be developed in order to support clinical decisions and lower healthcare costs.

2025-02-20·Cureus

Effectiveness of Atomoxetine and Stimulant Combination in Attention-Deficit/Hyperactivity Disorder (ADHD) Treatment: A Systematic Review

Review

作者: Boileau, Andrew J ; Cheng, Tom

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that can present with inattention, impulsivity, hyperactivity, or any combination of the three. For ADHD treatment, stimulants are widely considered first-line medications, with methylphenidate formulations being the most commonly prescribed. In patients who do not tolerate stimulants at higher doses, non-stimulant augmentation is a potential treatment strategy. Atomoxetine, as the first approved non-stimulant for ADHD by the United States Food and Drug Administration, has also been evaluated in several studies for combination therapies over the years. This review aims to investigate the effectiveness of combining stimulants such as methylphenidate with atomoxetine based on all newer studies, which came after the last major systematic review published in 2013. Six retrospective studies were included based on eligibility criteria among all studies published from 2012 to 2024 that were relevant to the research question. Three out of the six studies contained data regarding efficacy: one reported no significant difference in ADHD severity reduction between atomoxetine monotherapy and combination therapy overall, while two reported significantly decreased ADHD severity among treatment-resistant monotherapy patients after switching to combined methylphenidate and atomoxetine therapy. Four out of the six studies measured adherence: three reported significantly greater adherence with combined therapy versus monotherapy, while one reported that concomitant prescription of atomoxetine with methylphenidate significantly contributed to methylphenidate discontinuation. Limitations to this review include a limited quantity of total studies relevant based on the defined research question and the eligibility criteria, and lower certainty of evidence among them due to study limitations and even conflicts of interests. The heterogeneity in definitions and metrics carries over into population characteristics and analyses of each study, all of which contribute to the overall indirectness of evidence toward the defined question. For future studies, the current research question should be narrowed down to investigate specific ADHD patient subpopulations, with standardized protocols with consistent definitions and statistical methods to conduct prospective randomized controlled studies across multiple sites with longer follow-up periods, to have more meaningful answers regarding optimal combinations of atomoxetine with various stimulant formulations for long-term outcomes.

2025-02-01·Journal of Minimally Invasive Gynecology

Endometriosis Influencers on Instagram: Who are They and What are They Posting?

Article

作者: Gholiof, Mahsa ; Shiplo, Samantha N ; Leonardi, Mathew ; Sarin, Natasha

STUDY OBJECTIVETo examine endometriosis-related content on Instagram, a platform increasingly used for health communication, to understand: 1) the identity of Instagram content creators; 2) themes, tones, and emotions evoked from posts; and 3) accuracy of educational information. The relevance of this study lies in its potential to inform healthcare providers on how to better engage with social media to support individuals with endometriosis.DESIGNThis mixed methods cross-sectional observational study was performed on June 6, 2021. Instagram content was collected via two approaches: 1) searching hashtags related to endometriosis from a list of 30 hashtags and analyzing the top 20 and 10 most recent posts and 2) searching endometriosis-related terms under accounts to examine the first 30 accounts retrieved. Posts were categorized into themes and evaluated for tone and emotion, with educational posts also evaluated for accuracy.SETTINGPublicly available data on Instagram.PARTICIPANTSNone.INTERVENTIONSNone.MEASUREMENTS AND MAIN RESULTSThe study analyzed 768 Instagram posts and 228 accounts. Of these, 59.9% of posts and 92.1% of accounts contained endometriosis-related content. Most posts (55.4%) and accounts (59.0%) were authored by people with endometriosis. Accounts owned by people with endometriosis were significantly more active and had more followers compared to those who identified as healthcare providers (mean difference of total # of posts = 714.4, p < .001, mean difference of total # of followers = 27,194.7, p < .001, respectively). Social support was the most common theme (67.2%). Many posts had a negative tone (43.7%) and evoked sadness (57.6%). Objective educational posts contained 85.0% accurate information. Allied healthcare providers were most likely to post accurate educational information compared to all other content creators (p < .001).CONCLUSIONInstagram is widely used by people with endometriosis, with posts predominantly centered around social support and personal narratives. Healthcare providers can use this information better understand the experiences of people with endometriosis, and to engage more effectively on Instagram.

100 项与 Global University Systems BV 相关的药物交易

登录后查看更多信息

100 项与 Global University Systems BV 相关的转化医学

登录后查看更多信息