Research Corporation Technologies, Inc.

Dr. Kariuki brings a wealth of experience in ADCs, across corporate strategy, finance and operations Advancement of Pheon's differentiated ADC pipeline, accelerating first program, PHN-010, into clinical development this year LONDON, Sept. 10, 2024 /PRNewswire/ -- Pheon Therapeutics (Pheon), a leading Antibody-Drug Conjugate (ADC) specialist developing next generation ADCs for a wide range of hard-to-treat cancers, today announces the appointment of accomplished biotech executive, Enoch Kariuki, Pharm.D., to its Board of Directors as an independent, non-executive director. Dr. Kariuki possesses extensive strategic, operational, and financial life sciences experience. He most recently served as the Chief Executive Officer of Lengo Therapeutics, which was acquired by Blueprint Medicines. Prior to Lengo Therapeutics, he served as the Chief Financial Officer of VelosBio, which was acquired by Merck, where he led all finance-related and investor relations functions. Prior to that, he was Senior Vice President, Corporate Development at Synthorx, which was acquired by Sanofi. In addition, Dr. Kariuki previously served as Board Director and Audit Chair of Imago Biosciences which was acquired by Merck, and ProfoundBio which was acquired by Genmab. Cyrus Mozayeni, MD, Chief Executive Officer of Pheon, said: "Dr. Kariuki joins Pheon at a pivotal stage of growth, as we advance into clinical development with PHN-010, our lead ADC program targeting patients with advanced solid tumors. His decision to join Pheon's board reflects his belief in our innovative pipeline and our team's track record in targeted oncology therapies and ADCs. Dr. Kariuki brings a wealth of executive leadership experience and knowledge in ADCs, which further strengthens our board as we transition into a clinical stage company and beyond." Dr. Kariuki's appointment follows the completion of a $120m Series B financing round earlier this year to advance Pheon's three first-in-class ADC assets through clinical proof of concept. The company's first program, PHN-010, will enter Phase 1 clinical trials in 2024, targeting an undisclosed novel target which is overexpressed in a wide range of solid tumors. Enoch Kariuki, Pharm.D., newly appointed Board Member of Pheon, commented: "There have been tremendous advances in the evolving field of ADCs and through my previous experience in advising and investing in life sciences companies, I have become familiar with Pheon's innovative work. I am excited to contribute to Pheon's development of next generation ADCs and to help advance these transformative therapies for the benefit of patients in need." Dr. Kariuki currently serves on the board of Zentalis Pharmaceuticals and is President of Endeavor BioMedicines. Earlier in his career, Dr. Kariuki was Vice President at H.I.G. Capital, a private equity firm managing over $60 billion in assets, where he invested in and served on the boards of multiple life sciences companies. His other previous positions include Senior Associate at Leerink Partners and Associate Director at UBS Investment Bank, where he advised healthcare companies on equity capital financings, mergers and acquisitions, leveraged buyouts, and recapitalizations. Dr. Kariuki completed a Post-Doctoral Fellowship in R&D Strategy and Analytics at Bristol-Myers Squibb and was a Pharmacist at CVS Caremark. He holds an MBA from the Tuck School of Business at Dartmouth College and a PharmD from Texas Southern University. About Pheon Therapeutics Pheon Therapeutics is an Antibody Drug Conjugate (ADC) specialist developing a pipeline of ADCs, based on novel targets and novel linker payloads, to treat solid tumors. Pheon's lead program is a first-in-class ADC program against a novel target that is highly overexpressed in solid tumors across a broad range of hard-to-treat cancer types. Pheon is backed by expert, specialist healthcare investors TCGX, Atlas Venture, BVF Partners, Brandon Capital, Forbion, Lightspeed Venture Partners (Lightspeed), Perceptive Advisors, and Research Corporation Technologies. Pheon has a world class, proven leadership team that brings together the best of ADC engineering, clinical and managerial expertise, and track record. For further information, please visit SOURCE Pheon Therapeutics WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

声明：因水平有限，错误不可避免，或有些信息非最及时，欢迎留言指出。本文仅作医疗健康相关药物介绍，非治疗方案推荐（若涉及）;本文不构成任何投资建议。 目前ADC药物已成为最热门的创新药赛道之一，国内已有多家医药领域企业布局该赛道，各大企业纷纷利用融资来加大自身发展优势。2024年上半年，国内外已有21家ADC药企迎来了新一轮融资进展，融资总额约130亿元。小编汇总如下： 01 拓济医药:超亿元Pre-A轮融资 近日，国内领先的双抗ADC公司拓济医药（Phrontline Biopharma）宣布完成超亿元Pre-A轮融资，由德诚资本独家投资。本轮融资后，拓济将加大研发投入力度，加快多个临床前管线推进，升级自有技术平台，向着“成为全球领先的制药公司”愿景加速前进。 针对现有单抗ADC成药性痛点，拓济医药制定了高度前瞻性、差异化的管线策略，设计了全球首创的双靶点ADC、dual-linker-payload ADC等分子管线，带来更大的治疗窗并解决毒素耐药、低表达人群失效等单抗ADC面临的问题。目前公司多个双抗ADC管线正在快速推进。其核心研发项目TJ101与同靶点单抗ADC相比，在多种临床前肿瘤模型中体现出更优的肿瘤选择性和生长抑制效果。其潜在适应症包括肺癌、头颈癌等多种实体瘤。 02 InduPro:8500元美元A轮融资 2024年6月13日，InduPro宣布已经完成了8500万美元的A轮融资。本轮融资由the Column Group和Vida Ventures联合领投，其他投资者包括MRL Ventures Fund（默沙东的风险投资基金）、Emerson Collective和Euclidean Capital。 这笔资金将推动InduPro基于共同靶向对的邻近性，将其首个预期临床候选产品从临床前开发推进到2025年第四季度的1期临床试验预期IND申报。此外，资金还将用于新的双特异性抗体和抗体偶联药物（ADC）管线的开发，这些管线利用蛋白质邻近性来鉴定新的肿瘤选择性靶标对。 InduPro的双特异性ADC项目使用其TAPA治疗方法，根据发现的共靶对的邻近性，特异性靶向癌症组织。在“免疫突触调节”方法中，多特异性抗体针对靶点，在治疗自身免疫性疾病或免疫肿瘤学时，其诱导的邻近性募集并激活免疫细胞表面的蛋白质。这轮融资的成功完成，不仅为InduPro提供了推进其创新药物开发的动力，也体现了投资者对于公司研发实力和基于蛋白质邻近性新药开发潜力的信心。随着临床项目的不断深入，InduPro有望为癌症和自身免疫性疾病患者带来新的治疗选择。 03 Adcytherix:3000万欧元种子轮融资 6月11日，法国马赛，Adcytherix SAS宣布完成3000万欧元（约3200万美元）的种子轮融资，用于开发新型抗体偶联物药物（ADC），用于治疗癌症等高需求疾病。 种子轮融资由Pontifax领投，Pureos Bioventures、RA Capital Management和Dawn Biopharma（KKR控制的平台）跟投。管理层也参与了种子轮跟投。种子轮融资由Pontifax领投，Pureos Bioventures、RA Capital Management和Dawn Biopharma（KKR控制的平台）跟投。管理层也参与了种子轮跟投。 04 普灵生物:1700万元A2轮增资 2024年5月31日，复星医药发布控股企业苏州星未来基金、第三方红树林投资与普灵生物及其创始股东等共同签订《A2轮增资协议》，苏州星未来基金、红树林投资拟现金出资共计人民币 1,683.3333 万元认缴普灵生物新增注册资本合计人民币 1,230,506.79 元，其中：苏州星未来基金拟现金出资人民币 750 万元认缴新增注册资本人民币 548,245.61 元（即本次投资）。 普灵生物主要从事第四代抗体偶联药物（ADC）领域的研发， 依托其自主搭建的新一代药物偶联递送技术平台，可以针对不同靶点筛选适配的连接子-毒素系统，主要面向肿瘤治疗领域开展传统及新型 ADC 药物管线（包括纳米抗体ADC 、免疫调节类ADC 、抗体偶联类AOC）的开发。截至 2024年5月31日，普灵生物推进中的4条抗体偶联药物（ADC）管线均处于临床前研究阶段，目标适应症包括肺癌、卵巢癌等；另有1条抗体核酸偶联药物（AOC）管线处于概念验证阶段。 05 Pheon:1.2亿美元B轮融资 2024年5月21日，ADC公司Pheon Therapeutics（Pheon）宣布完成1.2亿美元（约8.68亿元）的B轮融资，本轮融资将使Pheon的业务持续到2027年，并支持三款ADC的早期临床测试。 此次融资由TCGX领投，新投资者BVF Partners、Lightspeed和Perceptive Advisors以及现有投资者Atlas Venture、Brandon Capital、Forbion 和 Research Corporation Technologies参投。作为融资的一部分，TCGX的执行合伙人Cariad Chester 将加入董事会。 新的融资将用于进一步推动Pheon的差异化ADC产品管线通过临床概念验证。Pheon的三项主要资产针对的是一个未公开的新靶点，该靶点在多种实体瘤中高度过表达。第一个项目利用DAR8拓扑异构酶-1抑制剂连接载体，展示了前所未有的临床前治疗指数，而接下来的两个ADC则利用其他连接载体技术挖掘这一靶点的广泛潜力。公司预计在 2024 年启动首个1期临床试验，并迅速向剂量扩展队列迈进。这笔资金还将使Pheon的一套内部技术平台能够扩展，以生成优化的ADC结构。 06 Endeavor:1.325亿美元C轮融资 4月24日，Endeavor BioMedicines宣布成功完成了1.325亿美元的C轮融资。Endeavor 将利用本轮融资推进ENV-101的临床开发，ENV-101是其用于治疗特发性肺纤维化 (IPF) 和进行性肺纤维化 (PPF) 的主要候选药物；并通过临床概念验证研究推进ENV-501，一种用于治疗HER3阳性实体瘤的人类表皮生长因子3 (HER3) 抗体-药物偶联物 (ADC)。 本轮融资由Matrix Capital Management旗下的AyurMaya领投。新投资者包括Fidelity Management & Research Company、Invus、SymBiosis、Velosity Capital和Woodline Partners。现有投资者包括abrdn管理的基金、Ally Bridge Group、Avidity Partners、Eckuity Capital、Longitude Capital、Omega Funds、Perceptive Advisors、Piper Heartland Healthcare Capital、Silver Arch Bio和T. Rowe Price Associates也提供了强有力的支持。 07 TORL:1.58亿美元B2轮融资 4月10日，专注于开发癌症治疗的新生物制剂的生物制药公司TORL BioTherapeutics宣布完成1.58亿美元的B2轮融资。本轮融资由Deep Track Capital领投，RA Capital Management、Perceptive Advisors和Avidity Partners在内的生物技术投资者以及所有现有生物技术投资者的跟投。 融资资金将用于继续ADC药物TORL-1-23的临床开发，推进TORL-1-23项目到第一阶段，以及将于今年下半年开始的关键第二阶段。这项2期临床试验旨在促进TORL-1-23作为CLDN 6+铂类耐药卵巢癌患者的新疗法的监管审查和潜在批准。所得资金还将用于推进TORL-2-307正在进行的一期研究，TTORL-2-307是一种用于治疗CLDN 18.2+实体瘤的临床阶段ADC药物，TORL-3-600是一种CDH17+结直肠癌ADC 08 BrickBio:未公布融资金额 3月18日，BrickBio获得了三星风险投资公司的投资。该公司打算利用这笔资金支持其蛋白质工程技术和临床前资产的进一步开发和进步。这项最新投资反映了三星致力于发现和探索生物制药领域的新机遇，以满足尚未得到满足的治疗需求。三星的子公司将与BrickBio合作，利用BrickBio专有的蛋白质工程技术评估、生产和开发先进的分子和疗法，用于ADC、AAV基因疗法和其他药物。 BrickBio 是一家生物技术公司，由首席执行官John Boyce 领导，提供位点特异性和位点选择性平台，涵盖原核和真核表达系统，能够开发具有增强特性的独特生物制剂和蛋白质疗法，包括改善半衰期、剂量和疗效。借助一套生物共轭处理工具，它可以优化任何共轭物。该公司正在扩大其治疗项目，包括ADC、双特异性共轭物和新型支架。 往期文章：13家ADC药企获得超80亿元融资（2024 Q1）             国内125家ADC企业盘点 参考资料：各公司公告

Financing led by TCGX, including new investment from BVF Partners, Lightspeed Venture Partners (Lightspeed) and Perceptive Advisors Three first-in-class ADC assets funded through clinical proof of concept LONDON, May 21, 2024 /PRNewswire/ -- Pheon Therapeutics (Pheon), a leading Antibody-Drug Conjugate (ADC) specialist developing next generation ADCs for a wide range of hard-to-treat cancers, today announces the completion of a $120m Series B financing to fund the development of its pipeline of differentiated ADCs. The financing was led by TCGX with participation from other new investors BVF Partners, Lightspeed and Perceptive Advisors, alongside existing investors Atlas Venture, Brandon Capital, Forbion, and Research Corporation Technologies. The new financing will be used to further advance Pheon's differentiated ADC pipeline through clinical proof of concept. The first three assets are aimed at an undisclosed novel target which is highly overexpressed in a wide range of solid tumors. The first program has demonstrated an unprecedented preclinical therapeutic index while utilizing a DAR8 Topoisomerase-1 inhibitor linker-payload, whereas the next two ADCs utilize other linker-payload technologies to mine the broad potential of this target. The company expects to start its first Phase 1 clinical trial in 2024 and rapidly advance towards dose expansion cohorts. The capital will also enable the expansion of Pheon's suite of in-house technology platforms to generate optimized ADC constructs. Cyrus Mozayeni MD, Chief Executive Officer of Pheon, said: "This raise is a critical step as we transition into a clinical-stage company. The proceeds will fund a robust clinical development pathway for our first three ADC assets, which are based on an exceptional novel target. We are excited to be working on these promising candidates and look forward to sharing their potential therapeutic benefits with patients." Cariad Chester, Managing Partner of TCGX, commented: "The recent clinical successes of optimized ADC constructs validate the promise of this therapeutic modality to treat solid tumors. Continued progress against cancer is predicated upon innovative approaches to new targets. Pheon has an exciting pipeline of first and best-in-class ADC programs and I look forward to working with the company as it enters into the next stage of growth and development." As part of the financing, Cariad Chester, Managing Partner of TCGX, will join the board of directors. Notes to Editors About Pheon Therapeutics Pheon Therapeutics is an Antibody Drug Conjugate (ADC) specialist developing a pipeline of ADCs, based on novel targets and novel linker payloads, to treat solid tumors. Pheon's lead program is a first-in-class ADC against a novel target that is highly overexpressed in solid tumors across a broad range of hard-to-treat cancer types. Pheon is backed by expert, specialist healthcare investors TCGX, Atlas Venture, BVF Partners, Brandon Capital, Forbion, Lightspeed Venture Partners (Lightspeed), Perceptive Advisors, and Research Corporation Technologies. Pheon has a world class, proven leadership team that brings together the best of ADC engineering, clinical and managerial expertise, and track record. For further information, please visit About.TCGX TCGX is a healthcare investment firm dedicated to advancing disruptive medicines and supporting companies that can improve the lives of patients. TCGX invests in both private and public companies led by exceptional entrepreneurs focused on developing better treatment options for patients. TCGX has investment teams in Palo Alto and New York City. For more information, please visit About BVF Partners BVF Partners is a San Francisco-based investment management firm with a 30 year history of investing in public and private biotechnology companies. For more information, please visit: About Lightspeed Lightspeed Venture Partners is a multi-stage venture capital firm focused on accelerating disruptive innovations and trends in the Enterprise, Consumer, Health, and Fintech sectors. Over the past two decades, the Lightspeed team has backed hundreds of entrepreneurs and helped build more than 500 companies globally including Affirm, Carta, Cato Networks, Epic Games, Faire, Forty Seven, Guardant Health, Mulesoft, Navan, Netskope, Nutanix, Rubrik, Sharechat, Snap, Udaan, Ultima Genomics and more. Lightspeed and its global team currently manage $25B in AUM across the Lightspeed platform, with investment professionals and advisors in the U.S., Europe, India, Israel, and Southeast Asia. About Perceptive Advisors Founded in 1999 and based in New York, NY, Perceptive Advisors is an investment management firm focused on supporting the progress of the life sciences industry by identifying opportunities and directing financial resources to the most promising technologies in healthcare. For more information about Perceptive, visit SOURCE Pheon Therapeutics