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Innovations in intranasal vaccine delivery technology: needle-free vaccine delivery platforms can solve the problems of stockpiling, cold-chain management, and pandemic preparedness
作者: Zlelinski, Walter ; Sullivan, Timothy ; Taraporewala, Irach
A review.Innovative delivery technologies for the needle-free delivery of vaccines by the intranasal route offer advantages to traditional parenteral needle-based delivery systems developed and produced by the vaccine industry.Dry powder intranasal vaccine technologies have recently been developed.In addition, a rapid manufacturing technol. platform is described that offers distinct advantages for delivery of liquid vaccines, with future development for a breakthrough in situ aseptic reconstitution technol. for freeze-dried or spray-dried vaccine powders.This latter advance offers the potential for eliminating or markedly reducing the need for cold-chain management of vaccines during transport and storage.These new technologies have wide-ranging applications and advantages for the reliable and effective administration of vaccine products.
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