Antibody-dependent cellular phagocytosis (ADCP) is an immune biological process and plays a biological role in the clearance of tumor cells and the response to immune checkpoint inhibitors. However, the effects of ADCP on stomach adenocarcinoma (STAD) remain unclear. Clinical and genomic data were extracted from multiple datasets. The ADCP-related signature was established using Cox least absolute shrinkage and selection operator regression. Expression of the C5a receptor also known as complement component 5a receptor 1 in the tumor and adjacent-normal tissues was calculated using immunohistochemistry staining. Validation of the signature was conducted in the training and validation cohorts by Cox regression and log-rank tests. Furthermore, the immune infiltrates, the tumor immune dysfunction and exclusion score, and tumor mutation burden score were calculated using the corresponding algorithms, and Mann–Whitney U tests were used to evaluate the differences between groups. Seventy-three hub genes with predictive performance were identified to establish an ADCP-related signature. Accordingly, a 27-gene signature was established, C5a receptor also known as complement component 5a receptor 1, one of the signature genes, had higher expression in tumors than adjacent-normal samples, and its predictive performance was validated in the GSE84437 and The Cancer Genome Atlas cohorts. We found that the ADCP-related signature is an excellent prognostic predictor of STAD. Moreover, the molecular characteristics and some indices of response to immunotherapy differed between the high- and low-risk groups. We constructed a 27-gene signature that is associated with the prognosis and response to STAD-based immunotherapy and provide insights into the biological mechanisms underlying this predictive function.

2025-03-14·Medicine

From freehand to precision: Dynamic navigation systems in transmandibular nerve canal implantation: A case series

Article

作者: Che, Shiwei ; Awang, Raja Azman ; Wang, Wuxiang ; Ismail, Noor Huda

Rationale:This case series explores dynamic navigation systems (DNS) in transmandibular nerve canal implantation for patients with limited jaw space due to the proximity of the inferior alveolar nerve (IAN). The aim is to demonstrate how DNS improves implant placement precision and safety in cases where traditional methods face challenges.Patient concerns:The patients had limited bone height and proximity to the IAN, making traditional implant techniques challenging. Concerns included the risk of nerve damage and difficulties in achieving optimal implant placement due to anatomical constraints.Diagnoses:Both patients had severe bone resorption and insufficient bone height in the posterior mandible, with concerns about IAN positioning. The first patient had grade III mobility in tooth #46 with a periapical infection, while the second had bilateral posterior mandibular pain and grade III mobility in tooth #47.Interventions:Implants were placed using DNS, allowing precise planning and real-time guidance during surgery. Based on cone beam computed tomography, preoperative planning assessed bone height and IAN proximity. DNS ensured accurate implant placement, avoiding nerve interference, while bone grafts and growth factors were applied for healing.Outcomes:Both cases showed successful implant placement without complications like nerve damage or implant misplacement. Follow-up cone beam computed tomography scans confirmed well-positioned implants, with minimal bone resorption in the first case over 2 years and stable conditions in the second case after 6 months.Lessons:This series highlights DNS’s effectiveness in improving implant accuracy and reducing nerve injury risks, suggesting its value in complex dental implant surgeries.

2025-02-01·Journal of Endourology

Segmental Resection with Ureteral Reimplantation vs Radical Nephroureterectomy with Bladder Cuff Removal for Urothelial Carcinoma of Distal Ureter: A Propensity Score Matching Study in a Large Chinese Center

Article

作者: Tang, Qi ; Yang, Qian ; Huang, Yiwei ; Xu, Chunru ; Guan, Bao ; Li, Xuesong ; Zhou, Liqun ; Zhang, Huifeng ; Ren, Hanzhen ; Wang, Guoli ; Cao, Chao ; Tao, Zihao ; Zhang, Kai ; Luo, Kaishun ; Du, Yicong

Purpose: We aim to compare the clinical outcomes of radical nephroureterectomy with bladder cuff removal (RNU) and segmental resection with ureteral reimplantation (RR) in Chinese patients with distal ureteral urothelial carcinoma. Materials and Methods: A retrospective analysis of medical records was performed for 922 patients found to have distal ureteral cancer, defined as below the level of the iliac vessels, with 747 patients who underwent RNU and 175 who underwent RR included in the final analysis. The primary endpoints included clinical outcomes and changes in the estimated glomerular filtration rate (eGFR). Survival analysis was conducted using the Kaplan-Meier method, and propensity score matching (PSM) was utilized to mitigate selection bias between the two surgical approaches. Results: After PSM, the Kaplan-Meier survival curves demonstrated significant associations between surgical approach and both local recurrence-free survival (LRFS) and bladder recurrence-free survival (BRFS), but no significant differences were found in cancer-specific survival (CSS) and overall survival (OS). There were no significant differences in metastasis-free survival and contralateral recurrence-free survival between the two groups. Multivariate Cox regression analysis identified RR as an independent predictor of poorer outcomes for LRFS and BRFS. In addition, a significant increase in eGFR was observed following RR, whereas a significant decrease was noted after RNU. Conclusion: RR is associated with equivalent CSS and OS compared with RNU, even in the context of high-risk distal ureteral cancer, and results in improved postoperative eGFR, whereas the potential of RR to increase the risk of local tumor recurrence and intravesical recurrence requires clinical consideration.

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100 项与昭通市第一人民医院相关的转化医学

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