This review focuses on why bio-capacitance has developed to become the standard online method to estimate biomass in cell-based bio-manufacturing processes. There is now a good understanding behind the apparent divergence seen between bio-capacitance and trypan blue based cell counts in the later stage of culture through recent works in the field of process monitoring. Methods for how various authors have been able to correct the bio-capacitance signal when required are discussed in this work. There is also a focus on the diversification and development of the probes for single use and smaller bioreactors. The review then describes the wide range of applications where bio-capacitance probes have been able to improve productivity. It includes on-line process control of perfusion-based processes, predictive feeding control of bioreactors, applications with attached cells and viral production. The work discusses the importance of scalability and the ability to validate the probes prior to manufacture and also reveals the additional process information that can be gleamed from the technology.

2011-12-01·BMC proceedings

Creating new opportunities in process control through radio frequency impedance spectroscopy

Article

作者: Carvell, John P ; Lee, Matthew P H ; Logan, Daniel W

Process control systems are a valuable tool in the research, development, and production stages of biopharmaceuticals. They allow cell culture processes to optimise product production through monitoring and controlling of the inputs to the system (e.g. air, temperature, feeds). Process control systems usually read an online monitor and adjust the inputs of the system to keep that monitor at a set point. The challenge with many process control systems is the inability to monitor the most informative variables online. Typically, surrogate variables such as pH and dissolved oxygen are monitored online and assumed to track changes in cell growth and product production. Although the simplicity of these types of probes has led to their wide use in most bioreactors, their use as effective process control drivers is limited by the assumptions required to link, for example, oxygen uptake rate to product formation. The ideal process control variable would be a direct measure of the desired product which is often difficult to monitor. However, in biopharmaceutical applications only the cells in the bioreactor are directly responsible for the production of the desired products. Online monitors which measure the cell number (or volume) offer a superior method for tracking cell/product growth and can be used to control and optimise the process control. Radio frequency impedance spectroscopy is one such method that offers an opportunity to monitor cell growth directly online and adjust the fermentation process accordingly.

2011-12-01·BMC proceedings

On-line monitoring of the live cell concentration in bioreactors based on a rocking platform

Article

作者: Lee, Matt ; Carvell, John

Background Aber Instruments first introduced the concept of using disposable live-biomass probes in 2009 [1]. The probe has been carefully designed to be welded into most single use bioreactors and is suitable for bags with agitators eg the Hyclone SUB and the Sartorius Stedim Biostat Cultibag STR, or those using the rocker type platform eg Sartorius Stedim Biostat Cultibag RM and GE Wave bioreactors . The disposable biomass probe has four electrodes with the same dimensions as the existing reusable production biomass probes with flush platinum electrodes that are used in cGMP manufacture worldwide. The electrode support material is HDPE that meets FDA and USP Class VI requirements and the probe can withstand gamma sterilisation and be stored for prolonged periods before use. The disposable probe is easily connected to a mini-lightweight Futura preamplifier so that the weight load or torque on the bag is minimal and the bulk of the electronics is then located well away from the bag. The disposable probe has already been welded into different bags including Sartorius Stedim Biotech CultiBag RM bioreactors.

项与 Aber Instruments Ltd. 相关的新闻（医药）

2025-01-16

·Business Wire

Single-use Technologies for Biopharmaceuticals Market to 2029 with Sartorius, Danaher, Merck, and Thermo Fisher Scientific Leading the $11.2 Billion Industry - ResearchAndMarkets.com

DUBLIN--( BUSINESS WIRE )--The "Single-use Technologies for Biopharmaceuticals Market" report has been added to ResearchAndMarkets.com's offering. The Single-use Technologies for Biopharmaceuticals was valued at USD 6.5 billion in 2024, and is projected to reach USD 11.2 billion by 2029, rising at a CAGR of 11.60%. This report summarizes the single-use technologies market, including a market snapshot and company profiles of key players. It provides a comprehensive market breakdown with in-depth information regarding each segment. The overview section of the report describes market trends and dynamics, including drivers, challenges and opportunities for the market. It provides information on emerging technologies and developments in the industry. It analyzes critical market players' financials, product portfolios and recent activities. The report analyzes and makes projections for each market and its applications, along with forecasts for the next five years. The report also features profiles of leading companies in the biopharmaceutical single-use technologies industry, including Sartorius AG, Danaher Corp, Merck KGaA and Thermo Fisher Scientific Inc. Key Findings The increasing demand for personalized medicine and the growing number of single-use product launches in bioprocessing operations drive the market's growth. The integration challenges and regulatory validation requirements challenge the market's growth. This report segments the global market by technology type, component type, application, end user and region. By technology type, single-use bioreactors held the largest market share in 2023, and this segment is expected to grow at a CAGR of 12.3% during the forecast period. In terms of application, the monoclonal antibodies segment is forecast to grow at a CAGR of 11.3% during the forecast period. This segment accounted for 32.7% of the market in 2023, reaching a value of $3.6 billion through 2029. The bioprocess containers segment accounted for 17.6% of the market by component type in 2023. It is expected to grow at a CAGR of 10.1% during the forecast period, reaching a value of $1.8 billion by the end of 2029. North America held the largest regional market share with 31.5% in 2023. Increasing research and development (R&D) activities in cell and gene therapies and the significant regional presence of single use systems companies are responsible for the large share. The report includes: 220 data tables and 59 additional tables An analysis of the global markets for single-use technologies for biopharmaceutical manufacturing Analyses of global market trends, with market revenue data from 2021 to 2023, estimates for 2024, and projected CAGRs through 2029 Estimates of the size and revenue prospects of the global market, along with a market share analysis by technology, single-use component, application, end user, and region/country A look at recent technical advances in different sole-use technologies and bioreactors and the extent of adoption by commercial customers and regulatory authorities Facts and figures pertaining to the market dynamics, technical advances, regulations, and the impact of region- and industry-specific macroeconomic variables A Porter's Five Forces model, and global supply chain and PESTLE analyses Patent activity and key patent grants/publications, along with an analysis of the impact of new developments in sole-use technologies and bioreactors for pharmaceuticals Overview of sustainability trends and ESG developments, with emphasis on consumer attitudes, ESG score analysis, and the ESG practices of leading companies Analysis of the industry structure, including company market shares, strategic alliances, M&A activity and a venture funding outlook Profiles of market leaders, including: Danaher Corp, Thermo Fisher Scientific Inc., Sartorius AG and Merck KGaA. Key Attributes: Report Attribute Details No. of Pages 207 Forecast Period 2024 - 2029 Estimated Market Value (USD) in 2024 $6.5 Billion Forecasted Market Value (USD) by 2029 $11.2 Billion Compound Annual Growth Rate 11.6% Regions Covered Global Key Topics Covered: Chapter 1 Executive Summary Market Outlook Scope of Report Market Insights Chapter 2 Market Overview Historical Analysis: The Foundation for Single-Use Technology Raw Materials Used in Single-Use Technologies Polyamide Polycarbonate Polyethylene Polyethersulfone Polypropylene Polytetrafluoroethylene Polyvinyl Chloride Cellulose Acetate Ethylene Vinyl Acetate Single-Use Technology Versus Traditional Reusable Technology Biologics Process Development Pathway and Application of Single-Use Technologies Upstream Processing Cell Harvesting and Clarification Downstream Processing Chapter 3 Market Dynamics Market Dynamics Snapshot Market Drivers Increasing Product Launches Growing Demand for Personalized Medicine Market Challenges and Restraints Stringent Regulations and Validation Requirements Disposal of Plastic Waste Integration Challenges Market Opportunities Growing Adoption for Monoclonal Antibodies Manufacturing Single-Use Systems in Downstream Operations Chapter 4 Emerging Technologies and Developments Introduction Real-Time Monitoring of Operations Miniaturization of Bioreactors Integration of Automation and Robotics Integrated Continuous Bioprocessing Chapter 5 Market Segmentation Analysis Segmentation Breakdown Market Analysis by Technology Single-Use Bioreactors Mixing, Storage and Filling Systems Filtration Systems Control Systems Freeze and Thaw Systems Chromatography Systems Centrifugal Pumps Isolators Market Analysis by Component Bioprocess Containers Sampling Systems Single-Use Sensors Transfer Systems Media Bags Filter Cartridges Tubing Connectors Other Single-Use Products Market Analysis by Application Monoclonal Antibodies Vaccines Stem Cell and Other Cell Therapies Blood Derivatives Gene Therapy Recombinant Proteins Polyclonal Antibodies Market Analysis by End User Biopharmaceutical Companies and Contract Manufacturers Research Institutes and Academia Pathology Laboratories Geographic Breakdown Market Analysis by Region North America Europe Asia-Pacific Rest of the World Chapter 6 Competitive Intelligence Competitive Landscape Partnerships Acquisitions Facility Expansions Patent Analysis Chapter 7 Sustainability in the Single-Use Technologies for Biopharmaceuticals Market Sustainability in the Biopharmaceutical Single-Use Technologies Industry Understanding Environmental, Social and Governance Data Environmental Performance Social Performance Governance Performance Concluding Remarks Chapter 8 Appendix Methodology Sources Abbreviations Company Profiles Aber Instruments Ltd. Adolf Kuhner AG Cellexus Celltainer Corning Inc. Danaher Corp. Distek Inc. Eppendorf SE Getinge Lonza Merck KGaA Sartorius AG Thermo Fisher Scientific Inc. For more information about this report visit https://www.researchandmarkets.com/r/jf476 About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

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