The goal of this qualitative is to understand the views and opinions of patients with persistent lower back pain patients who are awaiting physiotherapy treatment with regards sleep their sleep health. The main questions it aims to answer are:
* Identify whether Patients with persistent lower back pain awaiting physiotherapy consider sleep health relevant to their condition.
* Understand whether persistent lower back pain patients awaiting physiotherapy consider sleep health within the remit of Physiotherapy?
* Understand how persistent lower back pain patients may want sleep health to be assessed or managed within an outpatient musculoskeletal Physiotherapy Setting?
Participants will undertake one semi structured interview and complete two secondary outcome measures: Pittsburgh Sleep Quality Index and Pain, Enjoyment of Life and General Activity Scale. Data will be analysed via Thematic Analysis.

开始日期2023-12-01

申办/合作机构

Sheffield Hallam University

[+1]

NCT05148702

/ Recruiting临床3期IIT

The EXTEND Trial: Fixed-extended-duration Antibiotics (28 Days) Compared to Standard Care Antibiotic Durations in Adult Patients With Complicated Intra-abdominal Infection and Their Impact on Treatment Failure

A multicentre, open label, two-arm, parallel group, pragmatic, randomised controlled trial with internal pilot. A total of 1166 consenting adult patients with cIAI will be recruited and randomised on a 1:1 basis between 28-days antibiotics and standard care antibiotics. Patients will be followed up for 180 days to determine cost effectiveness and the rate of treatment failure in each group.

开始日期2022-10-10

申办/合作机构

The University of York

[+5]

100 项与 Chesterfield Royal Hospital NHS Foundation Trust 相关的临床结果

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项与 Chesterfield Royal Hospital NHS Foundation Trust 相关的文献（医药）

2025-07-01·DIGESTIVE AND LIVER DISEASE

The UK nationwide observational study of colon capsule: CAP ACCESS study

Article

作者: Koulaouzidis, Anastasios ; Kiladze, Giorgi ; Patel, Sachin ; Ibrahim, Hussain ; Fisher, Ian ; Hunt, Catherine ; Arefin, Aamerrashad ; Jarocki, Matthew ; Pillay, Lushen ; Lei, Ian Io ; Mcgreevy, Conor ; Beshyah, Waleed ; Arasaradnam, Ramesh P ; Nair, Sujith Sasidharan ; Ambler, Tracey ; Nizar, Zanil Yoonus ; Jardine, Ruari

BACKGROUND:

Colon capsule endoscopy (CCE) is increasingly used as an alternative to optical endoscopy (OE), particularly in Europe. However, challenges like low completion rates, inadequate bowel preparation, high conversion to OE, and discrepancies in findings remain. Accurate polyp size measurement in CCE is essential to avoid unnecessary procedures due to size overestimation.

OBJECTIVE(S):

This retrospective study analysed real-world data to compare polyp size measurements between CCE, OE, and histopathology (HP) and assess the impact on the need for further procedures.

METHODS:

Data from 2508 participants across 12 UK centres were analysed, with 4898 polyps identified via CCE. Polyps were matched with OE and HP reports based on size, location, morphology, sequence, and count, including those meeting ≥3 criteria. Regional data from Scotland and England were compared.

RESULTS:

Half of the CCE patients required follow-up OE, with 29 % undergoing colonoscopy. Among these, 32 % required OE for polypectomy, and 18 % due to incomplete CCE. In these cases, CCE overestimated polyp size by an average of 2.5 mm compared to HP and 2.7 mm compared to OE, leading to 17.3 % of potentially deferrable procedures.

CONCLUSION:

one in six participants had a further procedure reflecting the overestimation of polyp size. AI advancement could enhance polyp measurement accuracy and reduce unnecessary procedures whilst improving the cost-effectiveness of CCE.

2025-06-01·JOURNAL OF EVALUATION IN CLINICAL PRACTICE

East Midlands Breast Pain Pathway: An Evaluation of Community Breast Pain Clinics Across the East Midlands Cancer Alliance

Article

作者: Mark Sibbering, D. ; Clifton, Kevin ; Bartholomeuz, Thilan ; Pirkle, Lucy ; Robertson, John F. R. ; Rogers, Veronica ; Stafford, Denise ; Ryan, Mike

ABSTRACT:

Rationale:

Research indicates that breast pain as the sole symptom has no association with breast cancer. However, patients with breast pain only are often referred onto urgent breast cancer diagnostic pathways, leading to unnecessary anxiety and overutilisation of secondary health care services. The novel community breast pain clinic (CBPC) service in the UK aims to improve patient care while providing system‐wide improvements for patients with breast pain, patients who have ‘red flag’ symptoms, as well as being cost‐effective.

Aim and Objectives:

This study seeks to evaluate and assess the impact of the CBPC on patient care, experience, and healthcare system improvements.

Methods:

Quantitative and qualitative analysis of CBPC was undertaken using data from CBPC based on a core data set designed by the programme team, secondary care follow‐up data, Patient Reported Outcomes Measure (PROMs) data and family history data.

Results:

The CBPC was well‐received by patients with 98.5% recommending the service. Additionally, health economic analysis indicated a cost benefit ratio of 1.23 in year 1, indicating a positive return on investment. Breast cancer incidence within the cohort was estimated at 3.2 per 1000, in line with population estimates in the literature. For those with a breast cancer diagnosis, there is no evidence of care delays or missed diagnoses via the service.

Conclusion:

The CBPC offers significant benefits in patient experience and value for money, with no evidence of reducing patient safety. The impacts of the clinics appear to be reproducible across all five centres in the East Midlands (a population of 5.5 million). Recommendations on further assessment on optimal staff mix and clinic cost mechanisms should be considered to maximise benefits.

2025-05-01·ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND

Role of procedure-specific consent forms in clinical practice: a systematic review

Review

作者: Bent, C ; Norvill, J ; Johnson, N ; Mawhinney, JA

Introduction:

Consent forms play an active role in the consent process with generic, handwritten consent forms (GCF) often the standard across the National Health Service. Increasingly, procedure-specific consent forms (PSCF) are being used as an alternative. However, concerns remain about whether they meet the standard for consent. We therefore conducted a systematic review with the objectives of investigating evidence for PSCF, study methodology and medicolegal criteria.

Methods:

This systematic review was prospectively registered on PROSPERO (CRD42023392693) and conducted from 1 January 1990 to 17 March 2023 using the MEDLINE, Embase, CINAHL, CENTRAL and Emcare databases. A grey literature search was also performed. All studies evaluating PSCF in medical and surgical settings were included. Risk-of-bias analysis was performed using ‘RoB 2’ and ‘ROBINS-I’. Meta-analysis was not possible because of the results’ heterogeneity.

Findings:

We identified 21 studies investigating PSCF with no systematic reviews and meta-analyses reported. Most studies were quality improvement projects (n = 10) followed by randomised studies (n = 5). No definitive legal guidance for PSCFs and no studies assessing their role in litigation post-procedural complications were identified. PSCFs were associated with improved documentation (70%–100%; n = 11) and legibility (100%; n = 2) compared with GCF. Randomised studies (n = 4) investigating patient understanding and recall for PSCF were inconclusive compared with GCF.

Conclusions:

The heterogeneous evidence available merely demonstrates superior documentation of PSCF compared with GCF. Studies do not adequately investigate the impact on informed consent and fail to address the associated legal concerns. Further randomised studies with patient-centric outcomes and consideration for medicolegal criteria are needed.

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100 项与 Chesterfield Royal Hospital NHS Foundation Trust 相关的转化医学

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