作者: Martinez, William E ; Lin, Wan-Chen ; Wong, Ngo Yin ; Lozano, Monica M ; Gutierrez, M Gertrude ; Arenas, Jaime E ; McGivern, Joseph G ; Sierra Chavera, Rodrigo ; Mok, Leo

The ability to detect and characterize drug binding to a target protein is of high priority in drug discovery research. However, there are inherent challenges when the target of interest is an integral membrane protein (IMP). Assuming successful purification of the IMP, traditional approaches for measuring binding such as surface plasmon resonance (SPR) and fluorescence resonance energy transfer (FRET) have been proven valuable. However, the mass dependence of SPR signals may preclude the detection of binding events when the ligand has a significantly smaller mass than the target protein. In FRET-based experiments, protein labeling through modification may inadvertently alter protein dynamics. Graphene Bio-Electronic Sensing Technology (GBEST) aims to overcome these challenges. Label-free characterization takes place in a microfluidic chamber wherein a fluid lipid membrane is reconstituted directly above the GBEST sensor surface. By leveraging the high conductivity, sensitivity, and electrical properties of monolayer graphene, minute changes in electrostatic charges arising from the binding and unbinding of a ligand to a native IMP target can be detected in real time and in a mass-independent manner. Using crude membrane fractions prepared from cells overexpressing monocarboxylate transporter 1 (MCT1), we demonstrate the ability to (1) form a fluid lipid bilayer enriched with MCT1 directly on top of the GBEST sensor and (2) obtain kinetic binding data for an anti-MCT1 antibody. Further development of this novel technology will enable characterization of target engagement by both low- and high-molecular-weight drug candidates to native IMP targets in a physiologically relevant membrane environment.

项与 Nanotech Biomachines, Inc. 相关的新闻（医药）

2021-07-20

·GlobeNewswire

Worldwide Graphene Industry to 2031 - In Depth-assessment

Dublin, July 20, 2021 (GLOBE NEWSWIRE) -- The "The Graphene Market Report 2021" report has been added to ResearchAndMarkets.com's offering. The market for graphene has grown hugely in the past decade, with numerous products now on the market and more to come as graphene producers record steadily increasing revenues and OEMs witnessing significant returns in clothing, sportswear, footwear, tires, batteries etc. Graphene is attracting increasing attention from investors, researchers and industrial players due to its exceptional mechanical, electronic, and thermal properties. Graphene is available in multi-ton quantities from many producers and has been identified by many industry sectors as a key material that will drive future product development in flexible electronics, smart textiles, biosensors, drug delivery, water filtration, supercapacitors and more. The Graphene Market Report 2021 is the most comprehensive and up-to-date report on graphene currently available, by the world's leading market authority on graphene and publisher of Graphene Magazine. Profiling over 300 companies, the report provides key information for investors and executives to enable them to understand and take advantage of the opportunities provided by graphene (other 2D materials are also covered). The Graphene Market Report 2021 contains: Key Topics Covered: 1 EXECUTIVE SUMMARY2 OVERVIEW OF GRAPHENE2.1 History2.2 Types of graphene2.3 Properties3 GRAPHENE QUANTUM DOTS3.1 Composition3.2 Comparison to quantum dots3.3 Properties3.4 Synthesis3.4.1 Top-down method3.4.2 Bottom-up method3.4.3 Comparison of synthesis methods3.5 Applications3.6 Markets3.6.1 Electronics and photonics3.6.2 Energy storage and conversion3.6.3 Sensors3.6.4 Biomedicine and life sciences3.6.5 Anti-counterfeiting3.7 Challenges3.8 Production of graphene quantum dots3.8.1 Current and projected revenues3.8.2 Pricing4 GRAPHENE PRODUCTION4.1 Quality4.2 Assessment of graphene production methods5 REGULATIONS5.1 Environmental, health and safety regulation5.1.1 Europe5.1.2 United States5.1.3 Asia-Pacific5.2 Workplace exposure6 GRAPHENE PATENTS AND PUBLICATIONS7 GRAPHENE PRODUCTION7.1 Commercial production capacities7.2 Graphene oxide and reduced Graphene Oxide production capacities7.2.1 By producer7.2.2 By region7.3 Graphene nanoplatelets production capacities7.3.1 By producer7.3.2 Production capacity by region7.4 CVD graphene film7.4.1 By producer7.5 Graphene production issues and challenges7.5.1 Oversupply7.5.2 Quality7.5.3 Large-volume markets7.5.4 Commoditisation7.5.5 Industrial end-user perspective8 GRAPHENE PRICING8.1 Pristine graphene flakes pricing/CVD graphene8.2 Few-Layer graphene pricing8.3 Graphene nanoplatelets pricing8.4 Graphene oxide (GO) and reduced Graphene Oxide (rGO) pricing8.5 Graphene quantum dots pricing8.6 Multilayer graphene (MLG) pricing8.7 Graphene ink9 MARKETS FOR GRAPHENE9.1 3D PRINTING9.1.1 Market overview9.1.2 Market prospects9.1.3 Market assessment9.1.4 Applications map9.1.5 Global market in tons, historical and forecast to 20319.1.6 Product developers9.2 ADHESIVES9.2.1 Market overview9.2.2 Market prospects9.2.3 Market assessment9.2.4 Applications map9.2.5 Global market in tons, historical and forecast to 20319.2.6 Product developers9.3 AUTOMOTIVE9.3.1 Market overview9.3.2 Market prospects9.3.3 Market assessment9.3.4 Applications map9.3.5 Global market in tons, historical and forecast to 20319.3.6 Product developers9.4 BATTERIES9.4.1 Market overview9.4.1.1 Battery market megatrends9.4.2 Market prospects9.4.2.1 Flexible and stretchable batteries9.4.3 Market assessment9.4.4 Applications Map9.4.5 Global market in tons, historical and forecast to 20319.4.6 Product developers9.5 COMPOSITES9.5.1 Market overview9.5.2 Fiber-based polymer composite parts9.5.2.1 Market prospects9.5.2.2 Market assessment9.5.2.3 Applications map9.5.3 Metal-matrix composites9.5.3.1 Market assessment9.5.4 Global market in tons, historical and forecast to 20319.5.5 Product developers9.6 CONDUCTIVE INKS9.6.1 Market overview9.6.2 Market prospects9.6.3 Market assessment9.6.4 Applications map9.6.5 Global market in tons, historical and forecast to 20319.6.6 Product developers9.7 CONSTRUCTION AND BUILDINGS9.7.1 Market overview9.7.2 Market prospects9.7.3 Market assessment9.7.3.1 Cement9.7.3.2 Asphalt bitumen9.7.3.3 Aerogels9.7.4 Global market in tons, historical and forecast to 20319.7.5 Product developers9.8 ELECTRONICS9.8.1 WEARABLE ELECTRONICS AND DISPLAYS9.8.1.1 Market overview9.8.1.2 Market prospects9.8.1.3 Market assessment9.8.1.4 Global market, historical and forecast to 20319.8.1.5 Product developers9.8.2 TRANSISTORS AND INTEGRATED CIRCUITS9.8.2.1 Market overview9.8.2.2 Market prospects9.8.2.3 Market assessment9.8.2.4 Applications map9.8.2.5 Global market, historical and forecast to 20319.8.2.6 Product developers9.8.3 MEMORY DEVICES9.8.3.1 Market overview9.8.3.2 Market prospects9.8.3.3 Market assessment9.8.3.4 Global market in tons, historical and forecast to 20319.8.3.5 Product developers9.9 FILTRATION9.9.1 Market overview9.9.2 Market prospects9.9.3 Market assessment9.9.4 Applications map9.9.5 Global market in tons, historical and forecast to 20319.9.6 Product developers9.10 FUEL CELLS9.10.1 Market overview9.10.2 Market prospects9.10.3 Market assessment9.10.4 Applications map9.10.5 Global market in tons, historical and forecast to 20319.10.6 Product developers9.11 LIFE SCIENCES AND MEDICINE9.11.1 Market overview9.11.2 Market prospects9.11.2.1 Drug delivery9.11.2.2 Imaging and diagnostics9.11.2.3 Implants9.11.2.4 Medical biosensors9.11.2.5 Woundcare9.11.2.6 Medical wearables9.11.2.7 Gene delivery9.11.3 Market assessment9.11.4 Applications map9.11.5 Global market in tons, historical and forecast to 20319.11.6 Product developers9.12 LIGHTING9.12.1 Market overview9.12.2 Market prospects9.12.3 Market assessment9.12.4 Applications map9.12.5 Global market in tons, historical and forecast to 20319.12.6 Product developers9.13 LUBRICANTS9.13.1 Market overview9.13.2 Market prospects9.13.3 Market assessment9.13.4 Applications map9.13.5 Global market in tons, historical and forecast to 20319.13.6 Product developers9.14 OIL AND GAS9.14.1 Market overview9.14.2 Market prospects9.14.3 Market assessment9.14.4 Applications map9.14.5 Global market in tons, historical and forecast to 20319.14.6 Product developers9.15 PAINTS AND COATINGS9.15.1 Market overview9.15.2 Market prospects9.15.3 Market assessment9.15.4 Applications map9.15.5 Global market in tons, historical and forecast to 20319.15.6 Product developers9.16 PHOTONICS9.16.1 Market overview9.16.2 Market prospects9.16.3 Market assessment9.16.4 Applications map9.16.5 Global market in tons, historical and forecast to 20319.16.6 Product developers9.17 PHOTOVOLTAICS9.17.1 Market overview9.17.2 Market prospects9.17.3 Market assessment9.17.4 Applications map9.17.5 Global market in tons, historical and forecast to 20319.17.6 Product developers9.18 RUBBER AND TIRES9.18.1 Market overview9.18.2 Market prospects9.18.3 Market assessment9.18.4 Applications map9.18.5 Global market in tons, historical and forecast to 20319.18.6 Product developers9.19 SENSORS9.19.1 Market overview9.19.2 Market prospects9.19.3 Market assessment9.19.4 Applications map9.19.5 Global market in tons, historical and forecast to 20319.19.6 Product developers9.20 GRAPHENE IN SMART TEXTILES AND APPAREL9.20.1 Market overview9.20.2 Market prospects9.20.3 Market assessment9.20.4 Applications map9.20.5 Global market in tons, historical and forecast to 20319.20.6 Product developers9.21 GRAPHENE IN SUPERCAPACITORS9.21.1 Market overview9.21.2 Market prospects9.21.3 Market assessment9.21.3.1 Flexible and stretchable supercapacitors9.21.4 Applications map9.21.5 Global market in tons, historical and forecast to 20319.21.6 Product developers9.22 OTHER MARKETS9.22.1 Audio equipment9.22.2 Sporting goods and apparel10 GRAPHENE PRODUCER ASSESSMENT10.1 Types of graphene produced, by producer10.2 Markets targeted, by producer10.3 Graphene product developers target markets11 GRAPHENE COMPANY PROFILES12 GRAPHENE EX-PRODUCERS AND PRODUCT DEVELOPERS12.1 Adama Materials12.2 Anderlab Technologies12.3 Aneeve Nanotechnologies LLC12.4 Apex Graphene12.5 Bluevine Graphene Industries12.6 Carben Semicon Ltd.12.7 Carbon Sciences12.8 California Lithium Battery12.9 Catalyx Nanotech, Inc.12.10 Celtig, LLC12.11 Durham Graphene Science Ltd.12.12 Epi-lab sp. z o.o.12.13 Global Graphene Technologies12.14 Grafetech Europe S.L.12.15 Graphene Devices, Ltd.12.16 Graphene Energy, Inc.12.17 Graphene Frontiers, LLC12.18 Graphene ESD Corporation12.19 Graphene Nanotech S.L.12.20 Graphene-RGY12.21 Graphene Sensors Inc.12.22 Graphene Technologies12.23 GraphenTech12.24 Grox Industries, LLC12.25 Hengli Shengtai (Xiamen) Graphene Technology12.26 Hycarb, Inc.12.27 Nanotech Biomachines, Inc.12.28 Nanotech Engineering, Inc.12.29 National Nanomaterials12.30 Qingdao Haoxin New Energy Technology12.31 Quantum Materials Corporation12.32 Quantum Seed12.33 Redex Nano Lab12.34 Sinocarbon Materials12.35 Solan12.36 SupraG Energy12.37 Tetrels Technology Corporation12.38 United Nanotech Innovations12.39 VN Graphene12.40 Wavve Stream12.41 Xolve, Inc.13 OTHER 2-D MATERIALS14 RESEARCH METHODOLOGY15 REFERENCES For more information about this report visit

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