The goal of this clinical trial is to learn about the effects of Ketamine Assisted Psychotherapy [KAP] on individuals with Post Traumatic Stress Disorder [PTSD]. The main questions it aims to answer are:
Does KAP improve symptoms of PTSD?
What changes in brain network connectivity are seen with KAP?

开始日期2023-12-31

申办/合作机构

The University of New Mexico

[+1]

NCT05889117 / RecruitingN/AIIT

Neurometabolic Effects of Theta-burst Treatment in Mild Traumatic Brain Injury

The goal of this clinical trial is to test a new type of magnetic brain stimulation in patients with persistent post-concussive symptoms. Participants will undergo detailed MRI scans before and after 30 treatment sessions (of 3-10 minutes each). The main questions the study aims to answer are:
Will this new type of treatment result in fewer symptoms and better daily functioning?
What are the effects of this treatment on brain functioning?

开始日期2023-10-30

申办/合作机构

The Mind Research Network

[+1]

NCT06005181 / RecruitingN/AIIT

The Synchrony Study: A Randomized Controlled Trial of Music Training for Children With a Fetal Alcohol Spectrum Disorder (FASD)

The goal of this clinical trial is to examine if music training improves behavioral or cognitive performance in children with prenatal alcohol exposure who meet research criteria for a fetal alcohol spectrum disorder. The main questions it aims to answer are:
Does music training improve behavioral regulation for children with an FASD
Does music training improve cognitive performance (attention and working memory) for children with an FASD.
The study has two interventions for each participant: music listening and piano training. Each participant will either practice piano daily for 12 weeks or listen to pre-selected music daily for 12 weeks. The order of the interventions will be randomized across participants. Assessment will occur before and after participation in each 12 week intervention.

开始日期2023-10-02

申办/合作机构

The Mind Research Network

[+1]

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2024-10-01·Molecular Psychiatry

Differences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset

Article

作者: Turner, Jessica ; Omlor, Wolfgang ; Georgiadis, Foivos ; Nguyen, Dana ; Sharkey, Rachel J ; Sponheim, Scott R ; Ramsay, Ian S ; Homan, Stephanie ; Kaiser, Stefan ; Rootes-Murdy, Kelly ; Preda, Adrian ; Sim, Kang ; Ehrlich, Stefan ; Nickl-Jockschat, Thomas ; Goltermann, Janik ; Salvador, Raymond ; Dannlowski, Udo ; Pomarol-Clotet, Edith ; Demro, Caroline ; Nenadic, Igor ; King, Margaret ; van Erp, Theo ; Karuk, Andriana ; Calhoun, Vince ; Peterson, Zeru ; Kirschner, Matthias ; Spalletta, Gianfranco ; Quidé, Yann ; Stein, Frederike ; Grotegerd, Dominik ; Brosch, Katharina ; Krug, Axel ; Ji, Ellen ; Bacon, Chelsea ; Meinert, Susanne ; Homan, Philipp ; Banaj, Nerisa ; Kircher, Tilo ; Green, Melissa Jane

AbstractFormal thought disorder (FTD) is a clinical key factor in schizophrenia, but the neurobiological underpinnings remain unclear. In particular, the relationship between FTD symptom dimensions and patterns of regional brain volume loss in schizophrenia remains to be established in large cohorts. Even less is known about the cellular basis of FTD. Our study addresses these major obstacles by enrolling a large multi-site cohort acquired by the ENIGMA Schizophrenia Working Group (752 schizophrenia patients and 1256 controls), to unravel the neuroanatomy of FTD in schizophrenia and using virtual histology tools on implicated brain regions to investigate the cellular basis. Based on the findings of previous clinical and neuroimaging studies, we decided to separately explore positive, negative and total formal thought disorder. We used virtual histology tools to relate brain structural changes associated with FTD to cellular distributions in cortical regions. We identified distinct neural networks positive and negative FTD. Both networks encompassed fronto-occipito-amygdalar brain regions, but positive and negative FTD demonstrated a dissociation: negative FTD showed a relative sparing of orbitofrontal cortical thickness, while positive FTD also affected lateral temporal cortices. Virtual histology identified distinct transcriptomic fingerprints associated for both symptom dimensions. Negative FTD was linked to neuronal and astrocyte fingerprints, while positive FTD also showed associations with microglial cell types. These results provide an important step towards linking FTD to brain structural changes and their cellular underpinnings, providing an avenue for a better mechanistic understanding of this syndrome.

2024-10-01·Network Neuroscience

A Bayesian incorporated linear non-Gaussian acyclic model for multiple directed graph estimation to study brain emotion circuit development in adolescence

Article

作者: Cai, Biao ; Calhoun, Vince D. ; Zhang, Aiying ; Wang, Yu-Ping ; Zhang, Gemeng ; Stephen, Julia M. ; Wilson, Tony W.

AbstractEmotion perception is essential to affective and cognitive development which involves distributed brain circuits. Emotion identification skills emerge in infancy and continue to develop throughout childhood and adolescence. Understanding the development of the brain’s emotion circuitry may help us explain the emotional changes during adolescence. In this work, we aim to deepen our understanding of emotion-related functional connectivity (FC) from association to causation. We proposed a Bayesian incorporated linear non-Gaussian acyclic model (BiLiNGAM), which incorporated association model into the estimation pipeline. Simulation results indicated stable and accurate performance over various settings, especially when the sample size was small. We used fMRI data from the Philadelphia Neurodevelopmental Cohort (PNC) to validate the approach. It included 855 individuals aged 8–22 years who were divided into five different adolescent stages. Our network analysis revealed the development of emotion-related intra- and intermodular connectivity and pinpointed several emotion-related hubs. We further categorized the hubs into two types: in-hubs and out-hubs, as the center of receiving and distributing information, respectively. In addition, several unique developmental hub structures and group-specific patterns were discovered. Our findings help provide a directed FC template of brain network organization underlying emotion processing during adolescence.

2024-08-01·Aging and disease

Cross-Vendor Test-Retest Validation of Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) for Evaluating Glymphatic System Function.

Article

作者: Singh, Herpreet ; Wang, Danny J J ; Maillard, Pauline ; Schwab, Kristin ; Ringman, John M ; Barisano, Giuseppe ; Lu, Hanzhang ; Caprihan, Arvind ; Liu, Xiaodan ; Satizabal, Claudia L ; Greenberg, Steven M ; Arfanakis, Konstantinos ; van der Kouwe, Andre ; Habes, Mohamad ; Helmer, Karl G ; Stables, Lara ; Shao, Xingfeng ; Fadaee, Elyas ; Fischl, Bruce ; DeCarli, Charles ; Gold, Brian T ; Jann, Kay

The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method was proposed to evaluate glymphatic system (GS) function. However, few studies have validated its reliability and reproducibility. Fifty participants' DTI data from the MarkVCID consortium were included in this study. Two pipelines by using DSI studio and FSL software were developed for data processing and ALPS index calculation. The ALPS index was obtained by the average of bilateral ALPS index and was used for testing the cross-vendor, inter-rater and test-retest reliability by using R studio software. The ALPS index demonstrated favorable inter-scanner reproducibility (ICC=0.77 to 0.95, P< 0.001), inter-rater reliability (ICC=0.96 to 1, P< 0.001) and test-retest repeatability (ICC=0.89 to 0.95, P< 0.001), offering a potential biomarker for in vivo evaluation of GS function.

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