→
According to an SEC filing
,
Aurinia
’s EVP of research
Robert Huizinga
and CMO
Neil Solomons
are both walking away by Halloween, and while no explanations are given, details of their severance packages were provided. Huizinga had spent the last nine years at Aurinia after the
Isotechnika
merger: first as VP, clinical affairs, then as EVP, corporate development before his latest promotion in 2020. Solomons co-founded Aurinia a decade ago and used to be VP of R&D with
Vifor Pharma
. The
Peter Greenleaf
-led Aurinia
just launched its “Get Uncomfortable” ad campaign
, urging lupus nephritis patients to schedule checkups with their doctor.
→
CRISPR Therapeutics
COO
Lawrence Klein
will not return
next year “to pursue external opportunities,” but he’ll stay until this year draws to a close. Klein was originally appointed VP, strategy in February 2016, eventually receiving promotions to CBO in 2019 and COO a year later. The search begins for a replacement as CRISPR and
Vertex
make their case to the FDA
for
exa-cel
, a once-and-done treatment for sickle cell disease and transfusion-dependent beta-thalassemia, after getting lapped by
bluebird bio
with
Zynteglo
.
→ Pairing up with
Eli Lilly
on AMPK activators a couple of weeks ago
in a deal that almost reaches the $500 million mark
,
Nimbus Therapeutics
has poached
Nathalie Franchimont
from
Biogen
, naming her CMO. Franchimont had recently led the multiple sclerosis and immunology development unit and she held a cornucopia of other positions in her 10 years with Biogen, which is pinning its Alzheimer’s hopes on
lecanemab
after the
Aduhelm
debacle. At
Amgen
, she worked in medical affairs and clinical development, specifically with the bone drug
denosumab
(now marketed as
Xgeva
and
Prolia
).
→
Serge Stankovic
is set to retire
as president of
Acadia Pharmaceuticals
at the end of the year. A former clinical development exec with
Teva
and
Alkermes
, Stankovic was named head of R&D at Acadia in 2015 and president in 2018, helping guide the San Diego biotech to its only approved drug in April 2016. The FDA gave the OK to
Nuplazid
for Parkinson’s disease psychosis, but Acadia’s been shooting bricks lately in other indications,
with CRLs
in
back-to-back years
for dementia- and Alzheimer’s-related psychosis. Upon his retirement, Stankovic will move into a part-time advisory role.
→
Arturo Molina
’s time is winding down as CMO of antibody-drug conjugate developer
Sutro Biopharma
, and Peer Review will keep its eyes peeled for his next destination
after he leaves on Nov. 4
. Sutro CEO
Bill Newell
will stand in for him until a permanent successor is found. Molina was VP of oncology scientific innovation at
J&J
’s California Innovation Center before he joined Sutro,
which struck an ADC deal with
Astellas
for $90 million upfront in late June.
→ As biotech stocks were going subterranean,
it dawned on
Sagimet Biosciences
that an IPO wasn’t prudent for them in March. This week there’s a new sheriff in town at the NASH-centered biotech, with
Dave Happel
taking over for
George Kemble
as chief executive. Since 2020, Happel had been president and CEO of
Cognoa
, and in an earlier role, he was EVP of commercial development and strategy for
Horizon
. With Happel in place, Kemble is sliding into the role of executive chairman, succeeding
Westlake Village BioPartners
managing director
Beth Seidenberg
.
→ It didn’t take long for ex-
Biotheryx
chief
Robert Williamson
to find his next gig,
landing at T cell-focused
Triumvira Immunologics
as president and CBO. Williamson was at the controls for Biotheryx when the protein degradation squad
garnered a $92 million Series E round
in May 2021, and as we told you, he
then became chief business and financial officer
at
OncoMyx
in March. Triumvira says
it’s constructing a new cell therapy manufacturing facility
in South San Francisco for its lead program,
TAC01-HER2
, that should open by next year.
→ Let’s Twist again:
Patrick Finn
has been promoted to
president and COO of DNA synthesis heavyweight
Twist Bioscience
, which
inked a $710 million antibody discovery deal
with
Boehringer Ingelheim
last year. Finn signed on as Twist’s SVP, commercial operations in February 2015 and was elevated to chief commercial officer in 2019. He’s also been VP of sales and marketing for
Enzymatics
, now known as
Qiagen
.
→
Positions are getting filled
left and right at antibody radiation-conjugate (ARC) player
Actinium
:
Jenny Hsieh
(chief strategy officer) was head of corporate strategy and operations with
Immunomedics
as it was being sold to
Gilead
for $21 billion. In March, the large pharma handed out pink slips
to 114 staffers that worked out of Immunomedics’ old HQ
in Morris Plains, NJ;
Sunitha Lakshminarayanan
(head of CMC and product development) previously took on the role of executive director, cell therapy process engineering at
Bristol Myers Squibb
;
Stephen Dressel
(VP, strategic finance and analysis) had a 10-year career at
Regeneron
and just spent a year and a half with
Dewpoint Therapeutics
as senior director, financial planning & analysis;
Peter Baker
(director, drug substance/drug products operations) helped manufacture
Lutathera
and
Pluvicto
as head of production at
Novartis
’
Advanced Accelerator Applications
; and
Micah Riskin
(director, product steward, manufacturing sciences & technology) has Bristol Myers ties and recently led process development and MSAT for
Imvax
.
But wait, there’s more
: Actinium has plucked
Akash Nahar
(VP, clinical development) from
Merck
, where he served as global product development lead for hematology;
Elaina Haeuber
(VP, head of clinical operations) is a veteran of
Syneos Health
who had been VP of operations at
WCG
until May; finally,
Madhuri Vusirikala
(VP, clinical development, bone marrow transplant and cellular therapy) and
Patrik Brodin
(VP, head of radiation sciences) round out the hiring bonanza.
→
Cameron Durrant
will be on the lookout for another COO and CFO as
Tim Morris
decamps from both posts at
Humanigen
and becomes finance chief
at
Opthea
, a retinal disease biotech that will be all set financially for the time being
with $170 million in funding
through
Carlyle
and
Abingworth
’s
Launch Therapeutics
and an additional $90 million private placement. The ex-CFO of
Iovance
and
AcelRx
just took another board seat at
Aquestive Therapeutics
over the summer.
→ As they build a plan around WHIM syndrome drug
mavorixafor
,
X4 Pharmaceuticals
has recruited
Mark Baldry
as chief commercial officer. A former commercial exec at
Shire
, Biogen and
Amicus
, Baldry has held this same post at
Wave Life Sciences
and
Freeline Therapeutics
. The highs haven’t outweighed the lows this year at X4,
scoring a $55 million PIPE
but
cutting 20% of its staff
and pruning the pipeline.
→ There’s a batch of new execs at
Anokion
, while the Swiss autoimmune biotech
also says
that
Stephan Kontos
will relinquish his CSO duties to chair the scientific advisory board.
Alison Long
(CMO) once led clinical R&D at
Spark
and had been the medical chief with now-defunct
Kaleido BioSciences
;
Glenn Booma
(chief strategy officer) is a
Genzyme
alum who had worked as a life sciences consultant for the past nine years; and
Stephanie Haller
(SVP, clinical operations) only needs to replace three letters on her business card after parting ways with
Alexion
, where she was senior director, clinical operations, therapeutic area lead, nephrology. Additionally, Anokion promoted
Kristie Grebe
from VP, clinical & translational development to SVP, immunology & translational medicine.
Pfizer
invested $35 million
into Anokion’s celiac disease therapy
KAN-101
last week.
→ The glycoproteomics specialists at
InterVenn Biosciences
have promoted
Erwin Estigarribia
to president and COO. Estigarribia brought plenty of diagnostics experience before coming to InterVenn in 2019, with stints as an operations exec at
CardioDx
and
Applied Proteomics
— and further back, he had a series of leadership roles with
Chiron
, Novartis and
Geron
.
→ We have all sorts of other CMO appointments to discuss, and
Edward Kim
is first up
at Swedish mental illness and addiction disorder biotech
Orexo
. Kim steps away from
Biohaven
, where he was head of medical affairs, and he’s a Novartis neuro alum who has further Big Pharma connections as the former schizophrenia therapeutic area leader at J&J’s
Janssen
.
→
PaxMedica
’s
modest IPO
may have been under the radar a couple months ago, but the New York biotech
has added some gravitas to the staff
with Big Pharma alum
Stefan Schwabe
as CMO. Schwabe spent more than a decade in neuro roles at J&J, Novartis and
Sanofi
, and since 2012 he had been CMO and EVP of R&D at
Supernus
, getting out of Dodge not long after the FDA
threw cold water on the latest pitch
for its Parkinson’s drug
SPN-830
earlier this month. PaxMedica is advancing its lead asset
PAX-101
(
intravenous suramin
) in autism spectrum disorder, with a preclinical study of the drug in the works for Fragile X-associated tremor/ataxia syndrome (FXTAS).
→
Mark Deeg
has been named
medical chief at
Enveda Biosciences
, a Boulder, CO startup that chalked up the cash
with a $51 million Series A
in June 2021. Deeg was once the chief medical and safety officer for Eli Lilly’s
Chorus
in his 10 years with the Indianapolis pharma, and the ex-
Regulus
CMO recently oversaw global clinical development at
Cullgen
. Elsewhere, Deeg earned a promotion to VP of R&D at
Pear Therapeutics
before taking the Cullgen job last year.
→ As Rob Thomson shed the interim label this season and is now bound for the World Series as manager of the Philadelphia Phillies, will we say the same someday
for interim CMO
Richard Graydon
’s job status at Seattle breast cancer biotech
Atossa Therapeutics
? Graydon worked on such drugs as
Carvykti
(
cilta-cel
) and
Imbruvica
as the senior director of clinical development for Janssen, and he has served as director of clinical development at
Daiichi Sankyo
.
→
Jens Würthner
has jumped on board
as CMO of Amsterdam’s
Scenic Biotech
, which allied with
Roche
two years ago in a development deal involving genetic modifiers
and raised $31 million in March
. Würthner’s Big Pharma background includes stops at
AstraZeneca
,
GSK
and as a clinical program leader at Novartis before pivoting to
ADC Therapeutics
in 2016. He had led global clinical development at ADC since January 2020.
→ To close this CMO loop, antimicrobial developer
Adaptive Phage Therapeutics
has tapped
Edward Fang
for the position. Fang has held this post before at
Adenium Biotech
and US-China outfit
MicuRx Pharmaceuticals
. In April, Adaptive Phage topped off the cash tank from its Series B from May 2021
to bring the total to $61 million
, and the following month it began the Phase I/II trial for its diabetic foot osteomyelitis treatment.
→ Ex-
Antios
chief
Greg Mayes
is shoring up his leadership
at Toronto psychedelics player
Reunion Neuroscience
with
Edward Smith
as CFO and
Aviva Asnis-Alibozek
as VP, medical affairs. Smith has held a string of CFO posts at
Lava Therapeutics
,
Marinus Pharmaceuticals
and
PolyMedix
, and he’s a board member at
Benitec Biopharma
. A one-time medical affairs director at AstraZeneca, Asnis-Alibozek was EVP of medical affairs during her six years at
TRM Oncology
.
→
Travis May
’s healthcare information upstart
Datavant
— a relative in the
Vivek Ramaswamy
family of “vants” — has crunched the numbers
and selected
Marla Kessler
as chief marketing officer. The Pfizer marketing vet followed up her 13 years at
IQVIA
with a recent yearlong stay at
Aetion
as chief customer officer.
→
Things can only get Better
: J&J alum
Diane Gomez-Thinnes
has joined
San Francisco-based
Better Therapeutics
as chief commercial officer. Last year, Gomez-Thinnes finished her 17-year tenure at J&J as the worldwide president of its medtech
Mentor
, and from there she became the president of US operations for
Galderma
.
→
Kleanthis Xanthopoulos
’ cell therapy crew at
Shoreline Biosciences
has welcomed
Charles Calderaro III
as chief technical officer. Calderaro knows his way around the space from his days at
Kite
, where he was in charge of CAR-T manufacturing as global head of technical operations. After several leadership positions in a 14-year period at
Genentech
, Calderaro moved on to
BioMarin
as SVP, global manufacturing from 2016-19.
→ CRO
Sannova Analytical
has saddled up
Jason Apter
as CEO and
Stephen Unger
as CFO. This isn’t Apter’s first time running things in the CEO seat, having called the shots previously as CEO at
Johnson Matthey’s
health division. Apter also has experience under his belt from
Millipore Sigma
and
Sigma-Aldrich
. Meanwhile, Unger hops aboard after a stint as CFO at
Quotient
and
Circulogene
Theranostics
.
→
Genuv
has named
Jenny Choih
president of its new Cambridge, MA-based subsidiary Genuv US. Choih joined Genuv in 2016, most recently serving as director of development. Earlier in her career, Choih was a consultant at
McKinsey
.
→
Intellia
CEO
John Leonard
is joining the likes of
Sean Parker
and
John Connolly
on the board of directors at
3T Biosciences
, a TCR startup that pulled together a $40 million Series A led by chairman
Sean Harper
and the folks at Westlake Village BioPartners. The
Abbott
and
AbbVie
alum is also a board member at IQVIA.
→ As
Redonda Miller
exits from the board of directors at
Invivyd
,
Christine Lindenboom
will step in
during a time of tumult
marked by last week’s layoffs and executive departures
after
Tillman Gerngross
bailed as CEO in February. An Amgen and Pfizer vet, Lindenboom is
Alnylam
’s SVP of investor relations & corporate communications.
→ Fred Hutch’s
Tom Lynch
has sewn up a spot
on the board of directors at
Flagship
’s
Foghorn Therapeutics
. Lynch’s appointment comes after the FDA threw down the stop sticks
with a full clinical hold
on Foghorn’s blood cancer drug
FHD-286
in August. A partial hold
was handed out
a few months before.
→
Expansion Therapeutics
has elected
Raymond Kelleher
to the board of directors at a time when drugging RNA continues to attract interest. Kelleher, a faculty member at Massachusetts General Hospital and Harvard Medical School, is managing director of
Cormorant Asset Management
.
→
Ubiquigent
has announced that
the company’s CSO
Sheelagh Frame
has joined its board of directors. Frame began her career at Ubiquigent in 2018 as head of biology before being promoted to her current position last year. Prior to this role, Frame was with
Cyclacel
and
Onyx
Pharmaceuticals
.
→
TC Biopharm
has finished setting up
its scientific advisory board, which now consists of:
Blythe Sather
(VP and head of research at
Tune
Therapeutics
),
Erin Adams
(professor at the University of Chicago),
Chris Bond
(experience from
Genentech
,
OncoMed
,
Juno
,
Celgene
and
Kite
),
Isabelle Riviere
(director of the cell therapy and cell engineering laboratory at Memorial Sloan Kettering Cancer Center),
Daniel Olive
(researcher at the Cancer Research Center of Institut Paoli-Calmettes), and
Uma Lakshmipathy
(head of patheon translation services and cell therapy R&D pharma services group at
Thermo
Fisher
).
→
Trinity Biotech
is adding a fresh face to its board of directors as two others hit the exit.
Tom Lindsay
joins as non-executive director, having served previously as president of
Alere’s
(now a part of
Abbott
) business in Africa and currently serves as a board member at
Genedrive
. At the same time, directors
Seon Kyu Jeon
and
Michael Sung Soo Kim
are heading out the door.
Illustration: Kim Ryu for Endpoints News