This research project will develop, deliver, and assess the efficacy of a new sexual violence (SV) prevention program for college students. The MOON program (Moving ON against sexual violence) aims to prevent sexual violence amongst university students, who are known to be an at-risk population for this form of violence.
The MOON program follows a bystander approach, aiming to teach and capacitate young adults to be active agents of prevention within their communities. To do so, the program combines education on several SV-related topics with skills-training activities.
Throughout five online sessions, the participants will be educated on topics such as sexual violence and consent, gender stereotypes, SV myths and bystander attitudes and behaviors. The main goal is to promote discussion forums, increase the participants knowledge on these topics and deconstruct pre-conceived beliefs/ideas that promote societal tolerance and acceptance of SV The program follows a bystander approach to support young adults in the development of bystander attitudes and behaviors that will help them act in situations of risk of SV. To achieve this goal, the program sessions will also have a major focus on building bystander prevention skills through online practical exercises (e.g., training scenarios).
Finally, the program also focuses on promoting empathy towards others, specifically in the context of sexual violence prevention. This focus aims to deconstruct victim blaming narratives and to build victim-support skills, to enhance the students' sense of responsibility and their proclivity to act and help others in need. Being empathic towards others is perceived as a crucial component in the bystander decision-making to intervene.
This clinical trial will apply the MOON program with university students nationwide in the Portuguese context and compare the participants who will take part in the program (experimental group) with other students who will not (control group). Thus, the RCT will be conducted with the following goals:
1. To assess the treatment's efficacy, by evaluating the program's ability to significantly reduce gender stereotypes, sexism, and rape myths; and to significantly increase active bystander attitudes and behaviors and empathy towards other people.
2. To examine the extent to which any changes are maintained three, six and nine months after the program's completion.
3. To assess mechanisms of change, i.e., to test whether changes in cognitive outcomes, namely in rape myth endorsement, are associated with changes over time in behavioral outcomes, as bystander attitudes/behaviors.
4. To investigate the role of age and gender as moderators of change over time in SV perpetration, gender stereotypes, sexism, rape myths, bystander attitudes and behaviors and empathy.

开始日期2025-02-10

申办/合作机构

University of Porto

[+2]

NCT06879639

/ CompletedN/A

The Effect of 10 Weeks of Physical Exercise on Glycated Hemoglobin and Blood Pressure in Elderly People with Multimorbidity Conditions: a Controlled and Randomized Study

The main objective of the study is to compare the effect of two different types of physical exercise modalities on glycated hemoglobin and blood pressure in elderly individuals with multimorbidity. The main characteristic of the proposal is that it is experimental, with two intervention groups with physical exercise that will be randomized in the order of participation of the groups and forwarded to the researchers regarding the evaluations and training periods. In addition, the study will be controlled, as it has a control group that will not perform any intervention with physical exercises during the study period. To allocate the participants in each exercise group and for the control group, the researchers will use the 1:1 method, the user will receive an automatic generator through the random.org website.
The main questions raised by the studies will be: Is land-based training more effective than aquatic training for this population in improving the primary outcomes? Is there a difference between training at these intensities and not doing any physical exercise in this population with these primary outcomes?
Participants in the 2 intervention groups will:
Train 3x per week for 10 weeks at intensities that will progress over the weeks.

开始日期2024-09-09

申办/合作机构

University of Porto

[+1]

NCT06830278

/ Active, not recruitingN/A

The Efficacy of a New Sexual Violence Primary Prevention Program for Adolescents: a Cluster Randomized Trial of the Stand Up Now Against Sexual Violence (SUN) Program

This research project will develop, deliver, and evaluate a new school-based sexual violence prevention program for high-school adolescents. The SUN program (Stand Up Now against sexual violence) aims to prevent the occurrence of sexual violence among adolescents. The program approaches sexual violence as a complex phenomenon which occurs in many contexts throughout life. This program approaches specific concepts associated with sexual violence, such as sexual consent, while acknowledging the association between this form of violence and other violent phenomena. The program uses a bystander approach to support adolescents in the development of bystander attitudes and behaviors, which can be used in situations where the risk of sexual violence may be present. These may include behaviors such as confronting someone who is trying to take advantage of another person or reporting someone who committed sexual violence. The program aims to reduce myths associated with sexual violence, to increase empathy in this context and to improve bystander skills. Program sessions will combine group discussions with skills-building exercises.
This study will apply the SUN program in school settings and compare the adolescents who will take part in the program with adolescents who will not. The study will evaluate changes in sexual violence myths, sexism, empathy, and bystander attitudes and behaviors. The authors hypothesize that by decreasing myths associated with sexual violence and sexism, and by increasing empathy in this context, the program will be able to increase the adolescents' capacity to intervene in real-world situations to prevent sexual violence (i.e., bystander attitudes and behaviors). Additionally, the programs' acceptability will be assessed through focus groups conducted with students. It is expected that this project will improve scientific knowledge regarding sexual violence prevention.

开始日期2024-06-01

申办/合作机构

University of Porto

[+3]

100 项与 Foundation for Science & Technology of Portugal 相关的临床结果

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0 项与 Foundation for Science & Technology of Portugal 相关的专利（医药）

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项与 Foundation for Science & Technology of Portugal 相关的文献（医药）

2024-01-01·Drone Systems and Applications

A critical theory of the drone in archaeology: on space, epistemology, and automation

作者: Carvalho, Daniel

This article seeks to establish a theoretical framework surrounding the drone and its use in archaeology. More than just a tool, this vehicle has revolutionized not only the practice of the discipline but also the way archaeologists approach their object of study. To highlight its theoretical components, we have established a dialog with the philosophy of technology and the archaeological dimension, to understand the implications and impositions that the drone implies for the activities of archaeologists. Passing through the verticalization of the gaze, the machinic rhythms and choreographies, and, finally, the theme of automation, we understand that the theory of the drone in archaeology is fertile ground for a critique of how technique shapes the discipline.

2012-02-01·Journalism

Interpretive journalism: A review of concepts, operationalizations and key findings

作者: Strömbäck, Jesper ; Salgado, Susana

The overall purpose of this article is to review theory and research on interpretive journalism, one of the key concepts in research on the style and character of news journalism. While it is often claimed that news journalism over recent decades has changed from being predominantly descriptive to becoming increasingly interpretive, our review suggests that there is a lack of systematic research in this area. The literature is furthermore characterized by different conceptualizations and operationalizations of interpretive journalism, as well as by different normative assumptions. Taken together, this suggests not only insufficient conceptual clarity, but also problems related to the comparability and cumulativity of findings. To remedy this, and based on our review of how interpretive journalism has been conceptualized and operationalized, this article suggests how interpretive journalism should be conceptualized and operationalized in order to increase conceptual clarity, comparability across studies, and ultimately research cumulativity.

Archeion

Web archives as research infrastructure for digital societies: the case study of Arquivo.pt

作者: Gomes, Daniel

项与 Foundation for Science & Technology of Portugal 相关的新闻（医药）

2024-11-01

·药事纵横

即将公布数据，诺和诺德命悬CagriSema

声明：因水平有限，错误不可避免，或有些信息非最及时，欢迎留言指出。本文仅作医疗健康相关药物介绍，非治疗方案推荐（若涉及）;本文不构成任何投资建议。诺和诺德近期诸事不顺长期浸润在semaglutide带来鸿利之中的诺和诺德最近颇感受到“兴尽而悲”的滋味，诺和的股票近三个月下跌了13%左右，从高峰时期的938丹麦克朗（约合136美元，8月30日股价）跌至10月25日的783丹麦克朗（约合114美元）。诺和的市值，从7月6日的6407亿美元跌至10月25日的5109亿美元，暴跌20%（图1）。图1.诺和诺德市值走势图。（图片来源：Companiesmarketcap.com）除此之外，诺和基金会收购Catalent的交易也被美国参议员Elizabeth Warren投诉，后者上述美国联邦贸易委员会（FCT），警告诺和诺德收购Catalent可能会违背反不正当竞争法案，并希望FCT严查诺和的这笔交易。就连罗氏都站出来指责诺和基金会收购Catalent将阻碍蓬勃发展的减肥药市场。在这种“卧听竹屋萧萧响”的局面下，曾经“山顶千门次第开”的诺和诺德急需继续提振士气的催化剂，而他们倚重的减肥药“后浪”CagriSema有可能在年底的第四季度提供令诺和重返巅峰的关键临床读数。诺和诺德命悬CagriSema CagriSema是由诺和诺德开发的一种固定剂量组合药物，包含cagrilintide和semaglutide。Cagrilintide是一种胰淀素（Amylin）类似物，而semaglutide是Wegovy和Ozempic的有效成分。CagriSema设计用于每周一次的皮下注射，主要用于治疗肥胖、2型糖尿病和MASH（代谢功能障碍相关脂肪性肝炎）。 CagriSema的治疗假设基于其两种成分的互补机制。Cagrilintide作为胰淀素受体激动剂，帮助调节食欲和胃排空。胰淀素是一种与胰腺β 细胞一起释放的肽，其作用与GLP-1大致相同，既能减缓胃排空，又能诱导饱腹感，它不会直接引起胰岛素分泌。而semaglutide作为GLP-1受体激动剂，增强胰岛素分泌，抑制胰高血糖素释放，并减缓胃排空。通过这些作用，CagriSema可以改善血糖控制，减少体重，并可能在治疗MASH方面提供益处。 Citeline估计，CagriSema将在2030年实现年销售额210亿美元的高度，包括肥胖症和2型糖尿病。诺和诺德将于今年第四季度公布CagriSema的III期关键数据，这对于目前股价走低的诺和诺德来说可谓性命攸关。减肥候选药最重要的临床数据无疑是减重率，任何低于25%减重率的结果都可能对诺和诺德的股价造成严重的打击。安进肥胖症资产MariTide 的 II期数据也将在今年第四季度公布，如果减重率未能达到20-25%的区间，MariTide的前景将不被看好。 CagriSema跳过了肥胖症的II期试验，这得益于其有效成分cagrilintide和semaglutide已经分别针对肥胖症进行了临床研究。2022年，诺和诺德开始了CagriSema肥胖症的III期临床研究REDEFINE 1。Semaglutide的巨大成功已经将投资者的胃口吊得很高，CagriSema不得不面临一种“不审势即宽严皆误”的境地，临床数据不佳造成的负面影响将远远大于优秀临床结果对于股价的正向影响。所谓的积极临床数据阈值，对于CagriSema来说意味着25%的减重率，这是一个几乎可以匹敌减肥手术的减重率。与之形成对比的是，Wegovy在其关键肥胖症临床试验中的减重率为15%，而礼来的Zepbound在72周后的减重率约为23%。对于CagriSema设定如此之高的期待值，也反映了减肥药大干快上之后投资者一山望着一山高的心态。分析师已经对CagriSema临床数据对诺和诺德股价的影响做出了预测：如果CagriSema达到了25%的目标，诺和的股价可能上涨10%，而礼来的股价则可能受到蝴蝶效应的影响而下跌5%。然而如果CagriSema的表现不优于Wegovy，诺和的股价可能会暴跌10-20%，而如果CagriSema比Wegovy差，诺和的市值可能将瞬间蒸发20%甚至30%。如果CagriSema表现与Zepbound不相上下，这对诺和股价的影响很难预测，但礼来似乎可以坐收渔翁之利而坐享股价略微上涨。 CagriSema的另一个潜在问题是安全性，Bernstein的分析师曾经指出，在Cagrisema 的糖尿病II 期试验中，联合用药的胃肠道不良事件发生率几乎是单独使用每种药物的两倍，CagriSema为58%，semaglutide为32%，cagrilintide为33%。除了即将公布关键数据的REDEFINE 1之外，CagriSema还有一系列的III期临床研究将陆续公布结果： Ref. Cairns, E. Gaming Out The Scenarios For Cagrisema And MariTide. Scrip. 22. 10. 2024. Cairns, E. Cagrisema Leads The Charge For 2025. Scrip. 19.0 06. 2024 -END- 2025CMC-CHINA药博会 • 展位火热预定中！

并购临床2期

2023-10-13

·生物制品圈

2023年，生物制药圈的并购交易情况如何？（附统计表）

2023年，生物制药圈的并购交易不算多，也不算大。百时美施贵宝（BMS）以48亿美元收购Mirati Therapeuticsi的交易，是最近生物制药市场M&A（Mergers and Acquisitions）领域内的热门话题。这笔交易也折射出了2023年生物医药领域融资与M&A方面的现状。以BMS如此体量的生物制药公司48亿美元的价格收购Mirati的交易来看，反映出了2023年大型公司对较小“补强”型收购（Bolt-on）的普遍兴趣（Bolt-on 表示一家公司通过小规模的收购或合并，将新获得的业务或资产无缝地整合到其现有运营中，以实现战略增长和扩张。这种策略有助于最大限度地利用已有的资源和能力）。BMS将向 Mirati 支付每股 58美元(总计约48亿美元)，如果合并后七年内 Krazati（Mirati现有产品）的两项申请之一得到了批准，则将另外支付每股 12 美元 (总计约10 亿美元)。随着备受关注的 XBI 生物技术指数今年下跌 13%，每笔生物制药领域内的并购交易都有助于提振市场情绪。但BMI的这次收购却仍然投资者意兴阑珊，这个小型补强收购的价格并不令人满意。图1. 2023年上半年生物制药收购的交易总额与数量与往年比较图。（图片来源：Evaluate Pharma）2019 年，生物制药行业的收购交易创造了纪录，在那一年百时美施贵宝斥资 740 亿美元收购了Celgene，艾伯维630 亿美元收购了Allergan。2019年的前十大收购总额超过了 2000 亿美元。但随着新冠疫情的爆发，这一数字到 2021 年骤降至 530 亿美元。2022 年寒意依然犹在，高额并购活动更加稀缺，直到 12 月安进拟议以 278 亿美元收购 Horizon，才将年度总额推向了650 亿美元。经过 2022 年的低迷之后，生物制药领域内的并购活动在 2023 年有所回升（图1）。但几位大型制药公司的CEO一致表示，在当今环境下，大型交易是他们敬而远之的项目，有可能会对公司的核心目标和战略方向产生干扰甚至破坏。但到 2023 年中期，为了缓解专利悬崖和填补收入缺口，以及大型公司对于已上市或者后期资产的渴望，仍然推动了十几笔价值超过 10 亿美元的交易。包括辉瑞430亿美元收购Seagen（尚未完成，涉及四种已上市的癌症药物和众多临床阶段的后续项目）、默沙东108亿美元收购Promtheus（溃疡性结肠炎和克罗恩病的 III 期抗体，以及另一种临床抗体项目）、Astellas 59亿美元收购Iveric Bio（当时已经提交申请的补体C5抑制剂，治疗罕见的视网膜疾病地图样萎缩）、诺华32亿美元收购 Chinook Therapeutics（两种治疗罕见慢性肾病的晚期临床候选药物）等。但这些交易相对于2019年百时美施贵宝豪掷740亿美元收购Celgene的大手笔来说，从体量上看无不相形见绌。然而值得警醒的是，正是被收购的Celgene，其2023年在BMS内部资产销售额已经缩水到了只有7%的水平。虽然2023年也存在辉瑞收购Seagen的大手笔，但从整体来看，规模较小的补强交易是 2023 年并购领域的基调。除了商业风险较低之外，还可能避免被FTC（美国联邦贸易委员会）盯上的麻烦（反垄断法）。GlaxoSmithKline 20 亿美元收购 Bellus Health （3 期慢性咳嗽药物camlipixant），以及 Chiesi 在 2023 年初12.5 亿美元收购罕见疾病公司 Amyrt Pharma 的交易都符合这一模式。未来影响生物制药企业M&A的掣肘因素，除了市场本身的力量之外，还在于FCT对于反垄断法的监督和IRA（降低通胀法案）的影响。有两笔大型交易目前仍在 FTC 审查之下：辉瑞在 2023 年初以 430 亿美元收购 Seagen，以及安进去年年底宣布拟以 280 亿美元收购 Horizon。FTC对于超级并购案的高度关注，可能会对生物制药企业进行大宗交易的热情产生抑制作用。这在一定程度上也推动了补强型交易在今年的盛行。美国药品价格立法的影响是另一个潜在的抑制因素。一些行业观察人士表示，新法律将导致生物制剂比小分子产品更受青睐，并使多适应症产品（包括孤儿药）的吸引力降低。例如在今年完成了32亿美元收购Chinook Therapeutics交易的诺华，其CEO Vas Narasimhan 表示，诺华试图降低或者避免 IRA对其收购的不利影响。至于收购Chinook的交易，也是在考虑到适应症因素的基础上谨慎做出的，因为针对罕见慢性肾病的交易就IRA来说基本是可控的。在医药资本的寒潮下，在各种政策的掣肘下，生物制药的融资并购交易未来走向如何？您怎么看？附表：2023年生物制药企业并购交易 (截止2023年10月8日)Ref.Bristol Myers Squibb Strengthens and Diversifies Oncology Portfolio With Acquisition of Mirati Therapeutics. BMS. 08. 10. 2023.Swift, R. Astellas Pharma buys Iveric Bio for $5.9 billion. Reuters. 01. 05. 2023.Waldron, J. 'That's certainly on our minds': Novartis, GSK mull impact of IRA on R&D, M&A strategies. FierceBiotech. 26. 07. 2023.Feuerstein, A. Bristol ‘take-under’ of Mirati is not so great for biotech, but company’s new cancer target has potential. STAT. 09. 10. 2023.Dunleavy, K. Patent cliffs, divestitures and maturing biotechs all point to more pharma M&A: analysts. FiercePharma. 07. 09. 2023.Armstrong, A. et al. Fierce Biotech M&A Tracker 2023: Applied Molecular Transport finds a buyer; Atriva, Biocure ink reverse takeover. FierceBiotech. 05. 10. 2023.Biopharma Company Acquisition. Evaluate Pharma. Aug. 2023.

并购临床3期专利到期

100 项与 Foundation for Science & Technology of Portugal 相关的药物交易

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100 项与 Foundation for Science & Technology of Portugal 相关的转化医学

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