Delving into the Latest Updates on BiomEdit LLC with Synapse

概览

疾病领域	数量

感染	1

排名前五的药物类型	数量

重组多肽	1

排名前五的靶点	数量

CAMP(cathelicidin家族抗菌肽)	1

关联

1

项与 BiomEdit LLC 相关的药物

WO2023049162

专利挖掘

靶点

CAMP

作用机制-

在研机构

BiomEdit LLC

原研机构

BiomEdit LLC

在研适应症

感染

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期-

100 项与 BiomEdit LLC 相关的临床结果

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0 项与 BiomEdit LLC 相关的专利（医药）

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1

项与 BiomEdit LLC 相关的文献（医药）

Safety and efficacy of host-associated Latilactobacillus curvatus strains for potential probiotic applications in farmed Atlantic salmon (Salmo salar)

作者: Kumar, Arvind ; Gangaiah, Dharanesh ; Cathers, Hannah S. ; Krishnamurthy, Madan ; Wolter, Marilyn ; Mane, Shrinivasrao P. ; MacDonald, Alicia ; Tawari, Nilesh R. ; Martin, Roberto E. ; Nagireddy, Akshitha ; Plata, Germán ; Balakuntla, Jayanth ; Millman, Gregory ; Briones, Julian ; Baxter, Niel

AbstractSalmon aquaculture is the fastest growing animal protein production system in the world; however, intensive farming leads to poor weight gain, stress, and disease outbreaks. Probiotics offer the potential to enhance growth performance and feed efficiency in Atlantic salmon, as well as immunostimulate fish against common pathogens, benefitting farmers and consumers with more efficient production. Here, we isolated and identified 900 native microbial isolates including 18 Lactobacilli from farmed salmon intestines. Based on whole-genome sequencing and phylogenetic analysis, the Lactobacillus candidates belonged to Latilactobacillus curvatus (L. curvatus) species and formed two distinct phylogenetic groups.Using bioinformatics and in vitro analyses, we selected two candidates L. curvatus ATCC PTA-127116 and L. curvatus ATCC PTA-127117, which showed desirable safety and probiotic properties. The two L. curvatus candidates were evaluated for safety and efficacy in Atlantic salmon alongside spore-forming Bacilli isolated from salmon, poultry, and swine. All the tested candidates were safe to salmon with no adverse effects. While we did not see efficacy in any Bacillus supplemented groups, compared to untreated group, the group administered with the two L. curvatus strains consortium in feed for seven weeks showed significant improvement in final body weight by 4.2%. Similarly, the two L. curvatus candidates were also evaluated for safety and efficacy in Atlantic salmon in saltwater; the group administered with the two L. curvatus strains consortium in feed for 11 weeks showed significant improvement in final body weight by 4.7%. Comprehensive metabolomics analyses in the presence of different prebiotics and/or additives identified galactooligosaccharide as a potential prebiotic to enhance the efficacy of two L. curvatus candidates. All together, these data provide in silico and in vivo evidence of safety and efficacy of two novel endogenous L. curvatus candidates for potential economical and sustainable probiotic applications in salmon and likely other aquatic species.

100 项与 BiomEdit LLC 相关的药物交易

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100 项与 BiomEdit LLC 相关的转化医学

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