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项与 Upjohn Pharmaceuticals Ltd. 相关的药物

U-88999E

靶点

calcium channel

作用机制

calcium channel抑制剂

在研机构-

原研机构

Pharmacia & Upjohn Co., Inc.

在研适应症-

非在研适应症

脑血管疾病

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

U-92032

靶点

VDCCs

作用机制

VDCCs阻滞剂

在研机构-

原研机构

Pharmacia Corp.

在研适应症-

非在研适应症

认知障碍 [+1]

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

100 项与 Upjohn Pharmaceuticals Ltd. 相关的临床结果

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0 项与 Upjohn Pharmaceuticals Ltd. 相关的专利（医药）

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38

项与 Upjohn Pharmaceuticals Ltd. 相关的文献（医药）

2011-04-12·Journal of Pharmacy and Pharmacology3区 · 医学

Bioavailability of Bropirimine 250 mg Tablet in Dogs: Effect of Food

3区 · 医学

Article

作者: Yokohama, Shigeharu ; Nishihata, Toshiaki ; Emori, Hisatoshi ; Yamamoto, Ken

AbstractThe postprandial effect on the bioavailability of bropirimine in dogs after oral administration of bropirimine tablets (Bropirimine 250 mg Tablet) was investigated.At a dose of 500 mg bropirimine (two tablets of bropirimine 250 mg), the maximum plasma concentration under the postprandial condition was about twice that observed under the fasting condition, and the area under the plasma concentration vs time curve under the postprandial condition was also twice that under the fasting condition. The absolute oral bioavailabilities of bropirimine were 41.1% under the fasting condition and 83.5% under the postprandial condition.It is considered that the longer gastric residence time and larger volume of the gastric fluid induced by food-intake caused the increase in dissolution of bropirimine which increased the bioavailability after oral dosing of bropirimine 250-mg tablets.

2011-04-12·Journal of Pharmacy and Pharmacology3区 · 医学

Enhanced rectal absorption of itazigrel formulated with polysorbate 80 micelle vehicle in rat: role of co-administered esterase

3区 · 医学

Article

作者: Yamamoto, Ken ; Nishihata, Toshiaki ; Shah, Ashok C

AbstractWe investigated the effect of esterase on rectal absorption in the rat of itazigrel using polysorbate 80 (PS-80) micelle as a vehicle to overcome the poor aqueous solubility of itazigrel. The itazigrel formulation prepared with PS-80 increased the absorption compared with a 0·25% carmellose sodium suspension, probably by supplying the itazigrel solute to keep a high concentration at the epithelial surface. When esterase was co-administered with the formulations containing PS-80, the absorption of itazigrel from rat rectum was accelerated further, by rapid release of itazigrel from the micelle vehicle after enzymatic degradation of the PS-80 micelle.

2011-04-12·Journal of Pharmacy and Pharmacology3区 · 医学

Use of Enzymatic Activity for Design of Orally Administered Enteric Dosing Forms

3区 · 医学

Article

作者: Ishizaka, Mayumi ; Nishihata, Toshiaki ; Yamamoto, Ken

AbstractLiquid and semi-solid enteric dosage forms were prepared by entrapping drug with an appropriate partition coefficient in a lipid base vehicle which would then be released by the action of intestinal enzymes. Lipid ester derivatives such as glyceryl monocaprylate and polysorbate 80 were used as vehicles. These vehicles readily dissolved the poorly water-soluble compounds used in the study, itazigrel, indomethacin and the dye, sudan II, and were digested by lipase and esterase, releasing the test drugs with time profiles similar to those observed in dissolution studies. The vehicles released little or only a small amount of the drugs into aqueous medium in the absence of an appropriate enzyme. The enzyme-sensitive enteric vehicles when containing sudan II did not release the dye in the stomach of rats after oral administration, but released significant amounts of the dye in the small intestine.

100 项与 Upjohn Pharmaceuticals Ltd. 相关的药物交易

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100 项与 Upjohn Pharmaceuticals Ltd. 相关的转化医学

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