BioElectron Technology Corp.

近日，基因治疗龙头企业PTC Therapeutics（简称“PTC”）首席执行官Stuart Peltz 博士宣布，他将辞去已任职25年的CEO职位。 近日，基因治疗龙头企业PTC Therapeutics（简称“PTC”）首席执行官Stuart Peltz 博士宣布，他将辞去已任职25年的CEO职位。 Stuart Peltz 博士 自1998年PTC成立以来，Peltz博士就一直担任该公司首席执行官。在他的领导下，PTC已经从一个小体量的药物研究机构发展成为一家已上市的国际生物制药企业。Peltz博士辞去CEO职务后，将担任该公司的高级顾问，并加入其科学顾问委员会。 Matthew Klein博士 现任首席运营官Matthew Klein博士已被任命为公司新的首席执行官。在2019年加入PTC之前，Klein博士是BioElectron Technology Corporation的首席执行官兼首席医疗官，BioElectron Technology Corporation是一家生物技术公司，专注于开发用于线粒体疾病和氧化应激相关疾病的氧化还原活性小分子。PTC于2019年收购了BioElectron。作为BioElectron的首席执行官和首席营销官，Klein博士领导了公司的重组，成功实施了新的运营计划，并领导了两种针对CNS疾病的新型小分子的开发。Klein博士于2022年1月，被提拔为PTC的首席运营官，在AAV基因疗法Upstaza获欧盟批准上市的工作中发挥了主导作用。

- Chief Operating Officer Matthew Klein, M.D., M.S., F.A.C.S. to become Chief Executive Officer and join the Board of Directors – - Conference call to be held today, Fri., March 24th at 8:30 am ET - SOUTH PLAINFIELD, N.J., March 24, 2023 /PRNewswire/ -- PTC Therapeutics, Inc. (NASDAQ: PTCT). Stuart Peltz, Ph.D., founding Chief Executive Officer (CEO) of PTC Therapeutics announced today that he is stepping down after 25 years. Dr. Peltz has led PTC Therapeutics as its CEO since its founding in 1998 and pioneered the field of RNA-directed drug development. Under his leadership, PTC has grown from a research organization with expertise in the control of RNA processes to a publicly traded, integrated, global biopharmaceutical company focused on the discovery, development and commercialization of innovative therapies for the treatment of neurological and neuromuscular disorders, metabolic disorders, and cancer. "I have been involved with PTC almost since its inception. What Stuart and the team have achieved in 25 years is extraordinary," said Michael Schmertzler, Chairman of the Board of Directors. "The Board and I are confident in the team Stuart has built and their ability to continue to deliver transformative treatments to those living with rare diseases. We wish Stuart all the best in his future endeavors and look forward to his continuing contributions to the company." Matthew Klein, M.D., M.S., F.A.C.S., current Chief Operating Officer, has been named the company's CEO and will join the Board of Directors. The transition is effective immediately. Dr. Peltz will serve as a Senior Consultant to the Company and join its Scientific Advisory Board following his retirement. Prior to joining PTC in 2019, Dr. Klein was CEO and Chief Medical Officer at BioElectron Technology Corporation, a biotechnology company focused on the development of redox-active small molecules for mitochondrial disease and related disorders of oxidative stress. PTC acquired BioElectron's assets in 2019. As CEO and CMO of BioElectron, Dr. Klein led the restructuring of the company with successful implementation of new strategic and operational plans and led the development of two novel small molecules targeting CNS diseases from discovery to early and late clinical development stages. In addition, he oversaw the formation of an oncology platform that yielded several novel preclinical compounds with novel approaches to targeting cancer. Dr. Klein joined PTC as Global Head of Gene & Mitochondrial Therapies and then assumed the role of Chief Development Officer prior to promotion to COO in January 2022. At PTC, he has overseen the Company's broad development pipeline now with five ongoing registration-directed clinical trials and headed the efforts in achieving EMA approval for Upstaza, the first ever gene therapy directly administered to the brain. Dr. Klein holds a Bachelor of Arts in history, and graduated summa cum laude and phi beta kappa from the University of Pennsylvania. He received his Doctor of Medicine degree with honors from Yale University. In addition, Dr. Klein holds a Masters of Epidemiology degree from the University of Washington. Prior to leading BioElectron, he was the Auth-Washington Research Foundation Endowed Chair for Restorative Burn Surgery at the University of Washington. He has authored or co-authored over 100 peer-reviewed scientific publications and has served on the Research Advisory Board of the Shriners Hospitals for Children for over 15 years. "The PTC team and patients and families around the world have benefited tremendously from Stu's scientific expertise and leadership. I am grateful to the Board for its confidence in appointing me as his successor," said Dr. Klein. "I am extremely proud to have the opportunity to lead PTC's experienced and dedicated team into its next quarter century as we advance our pioneering science to develop valuable and transformative therapies for children and adults with unmet medical needs. We will enrich PTC's unwavering commitments to patients and to prudent enterprise growth based on our robust product portfolio, global commercial infrastructure, and unique scientific and drug development strengths." Today's Conference Call and Webcast information: To access the call by phone, please click here to register and you will be provided with dial-in details. To avoid delays, we recommend participants dial in to the conference call 15 minutes prior to the start of the call. The webcast conference call can be accessed on the Investor section of the PTC website at . A replay of the call will be available approximately two hours after completion of the call and will be archived on the company's website for 30 days following the call. About PTC Therapeutics, Inc. PTC is a science-driven, global biopharmaceutical company focused on the discovery, development and commercialization of clinically differentiated medicines that provide benefits to patients with rare disorders. PTC's ability to globally commercialize products is the foundation that drives investment in a robust and diversified pipeline of transformative medicines and our mission to provide access to best-in-class treatments for patients who have an unmet medical need. The company's strategy is to leverage its strong scientific expertise and global commercial infrastructure to maximize value for its patients and other stakeholders. To learn more about PTC, please visit us at and follow us on Facebook, on Twitter at @PTCBio, and on LinkedIn. For More Information: Investors: Kylie O'Keefe +1 (908) 300-0691 kokeefe@ptcbio.com Media: Jeanine Clemente +1 (908) 912-9406 jclemente@ptcbio.com Forward-Looking Statements: This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. All statements contained in this release, other than statements of historic fact, are forward-looking statements, including statements regarding PTC's strategy, future operations, future financial position, future revenues, projected costs; and the objectives of management. Other forward-looking statements may be identified by the words "guidance," "plan," "anticipate," "believe," "estimate," "expect," "intend," "may," "target," "potential," "will," "would," "could," "should," "continue," and similar expressions. PTC's actual results, performance or achievements could differ materially from those expressed or implied by forward-looking statements it makes as a result of a variety of risks and uncertainties, including the factors discussed in the "Risk Factors" section of PTC's most recent Annual Report on Form 10-K as well as any updates to these risk factors filed from time to time in PTC's other filings with the SEC. You are urged to carefully consider all such factors. The forward-looking statements contained herein represent PTC's views only as of the date of this press release and PTC does not undertake or plan to update or revise any such forward-looking statements to reflect actual results or changes in plans, prospects, assumptions, estimates or projections, or other circumstances occurring after the date of this press release except as required by law. Company Codes: NASDAQ-NMS:PTCT

SAN CARLOS, Calif. & SEATTLE--(BUSINESS WIRE)-- Nautilus Biotechnology, Inc., a company pioneering a single-molecule protein analysis platform for quantifying the human proteome, today announced the appointment of Matt Murphy, Esq., as General Counsel. This press release features multimedia. View the full release here: Matt Murphy Mr. Murphy brings more than 25 years of experience in senior legal counsel roles for companies on the cutting edge of life sciences technologies with specialization in biotechnology and diagnostics. He was previously the Vice President and General Counsel for 10x Genomics and Vice President of Intellectual Property and General Counsel for Pacific Biosciences. Prior to joining Nautilus, Mr. Murphy advised a wide range of leading technology companies including BioElectron Technology Corporation, Siluria Technologies, Inc., Nanosys, and Caliper Technologies. He previously served on the board of the Friends of School of the Arts Foundation, a non-profit corporation supporting arts and academic learning for students. Mr. Murphy received his B.S. in Microbiology and Fermentation Science from the University of California, Davis, and his J.D. from the University of San Francisco School of Law. “Matt is an accomplished leader with an exceptional background in building and defending intellectual property portfolios for life science and technology companies,” said Sujal Patel, co-founder and CEO of Nautilus Biotechnology. “We’re thrilled to welcome him to our executive leadership team as we scale our proteomic analysis platform in our mission to create a new standard for measuring the human proteome.” “In seeking to build a greater understanding of the proteome, Nautilus is looking to unlock the next level of understanding of biology beyond that already presented by the blueprint of genomics,” said Mr. Murphy. “I look forward to leading the company’s legal operations to support its continued growth and commitment to expanding rapid and comprehensive access and understanding of the proteome.” Nautilus is developing a unique proteomic analysis platform to accelerate the generation of proteomics-based insight, drive new discoveries, and propel the field forward to better understand our fundamental biology and the molecular mechanisms of disease. The company entered a definitive merger agreement with Arya Sciences Acquisition Corp III (Nasdaq: ARYA) (“ARYA III”) to be completed in the second quarter of 2021. Upon closing, Arya III will redomicile as a Delaware corporation, be renamed Nautilus Biotechnology, Inc. (the “Combined Company”) and its common stock is expected to be listed on Nasdaq under the ticker symbol “NAUT”. About Nautilus Biotechnology Nautilus is a biotechnology company who is developing a proteomics platform that aims to deliver superior sensitivity more quickly, more completely, and less expensively than is currently possible. Nautilus Biotechnology aims to enable a dramatic acceleration of basic science research, significantly improve the success rate of therapeutic development, and enhance opportunities for personalized and predictive medicine. Nautilus’ corporate headquarters is in Seattle, Washington and scientific research and development is being conducted from its San Carlos, California office and labs. About Arya III Arya III is a blank check company newly incorporated as a Cayman Islands exempted company for the purpose of effecting a merger, share exchange, asset acquisition, share purchase, reorganization or similar business combination with one or more businesses or entities. Arya III is led by Chairman Joseph Edelman, Chief Executive Officer Adam Stone, Chief Financial Officer Michael Altman and Chief Business Officer Konstantin Poukalov. Important Information and Where to Find It A full description of the terms of the proposed business combination transaction between ARYA III and Nautilus (the “Business Combination”) is set forth in a registration statement on Form S-4 (File No. 333-254796) filed with the Securities and Exchange Commission (“SEC”) by Arya III that includes a prospectus with respect to the Combined Company’s securities to be issued in connection with the Business Combination and a proxy statement with respect to the shareholder meeting of Arya III to vote on the Business Combination. Arya III and Nautilus urge their investors, shareholders and other interested persons to read the preliminary proxy statement/prospectus as well as other documents filed with the SEC because these documents contain important information about Arya III, Nautilus Biotechnology and the Business Combination. After the registration statement is declared effective, the definitive proxy statement/prospectus to be included in the registration statement will be mailed to shareholders of Arya III as of a record date to be established for voting on the proposed Business Combination. Shareholders of Arya III may also obtain a copy of the S-4, including the proxy statement/prospectus, and other documents filed with the SEC without charge, by directing a request to: ARYA Sciences Acquisition Corp III, 51 Astor Place, 10th Floor, New York, New York 10003, Attn: Secretary. The preliminary and, once available, definitive proxy statement/prospectus to be included in the registration statement can also be obtained, without charge, at the SEC’s website ( ). Participants in the Solicitation Arya III and Nautilus Biotechnology and their respective directors and executive officers may be considered participants in the solicitation of proxies with respect to the potential Business Combination under the rules of the SEC. Information about the directors and executive officers of Arya III is set forth in Arya III’s final prospectus filed with the SEC pursuant to Rule 424(b) of the Securities Act of 1933, as amended (the “Securities Act”) on August 10, 2020 and is available free of charge at the SEC’s website at or by directing a request to: ARYA Sciences Acquisition Corp III, 51 Astor Place, 10th Floor, New York, New York 10003, Attn: Secretary. Information regarding the persons who may, under the rules of the SEC, be deemed participants in the solicitation of the Arya III shareholders in connection with the potential Business Combination is set forth in the registration statement on Form S-4 containing the preliminary proxy statement/prospectus filed with the SEC. These documents can be obtained free of charge from the sources indicated above. Non-Solicitation This press release is not a proxy statement or solicitation of a proxy, consent or authorization with respect to any securities or in respect of the potential Business Combination and shall not constitute an offer to sell or a solicitation of an offer to buy the securities of Arya III, the Combined Company or Nautilus Biotechnology, nor shall there be any sale of any such securities in any state or jurisdiction in which such offer, solicitation, or sale would be unlawful prior to registration or qualification under the securities laws of such state or jurisdiction. No offer of securities shall be made except by means of a prospectus meeting the requirements of the Securities Act. Special Note Regarding Forward-Looking Statements This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act and Section 21E of the Securities Exchange Act of 1934, as amended, that are based on beliefs and assumptions and on information currently available. In some cases, you can identify forward-looking statements by the following words: “may,” “will,” “could,” “would,” “should,” “expect,” “intend,” “plan,” “anticipate,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “ongoing” or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. These statements involve risks, uncertainties and other factors that may cause actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. Although we believe that we have a reasonable basis for each forward-looking statement contained in this press release, we caution you that these statements are based on a combination of facts and factors currently known by us and our projections of the future, about which we cannot be certain. Forward-looking statements in this press release include, but are not limited to, statements regarding the proposed Business Combination, statements about the potential attributes and benefits of Nautilus Biotechnology’s proteomics platform, the potential market opportunity, and the development and performance of Nautilus Biotechnology’s platform. We cannot assure you that the forward-looking statements in this press release will prove to be accurate. These forward looking statements are subject to a number of risks and uncertainties, including, among others, the ability to complete the business combination due to the failure to obtain approval from Arya III’s shareholders or satisfy other closing conditions in the business combination agreement, the occurrence of any event or other circumstances that could give rise to the termination of the business combination agreement, the outcome of any legal proceedings that may be instituted against Nautilus Biotechnology or Arya III following announcement of the transactions, the risk that the proposed business combination disrupts Nautilus Biotechnology’s or Arya III’s current plans and operations as a result of the announcement of the transactions, the ability to recognize the anticipated benefits of the business combination, costs related to the business combination, the amount of redemption requests made by Arya III’s stockholders, changes in applicable laws or regulations, the possibility that the expected timeframe for, and other expectations regarding the development and performance of, Nautilus Biotechnology’s proteomic platform will differ from current assumptions, and other risks and uncertainties, including those included under the header “Risk Factors” in the registration statement on Form S-4 filed by Arya III with the SEC and those included under the header “Risk Factors” in the final prospectus of Arya III related to its initial public offering. Furthermore, if the forward-looking statements prove to be inaccurate, the inaccuracy may be material. In light of the significant uncertainties in these forward-looking statements, you should not regard these statements as a representation or warranty by Nautilus, ARYA III, the Combined Company or any other person that we will achieve our objectives and plans in any specified time frame, or at all. The forward-looking statements in this press release represent our views as of the date of this press release. We anticipate that subsequent events and developments will cause our views to change. Except as otherwise required by applicable law, Nautilus Biotechnology, Arya III and the Combined Company disclaim any duty to update any forward-looking statements. You should, therefore, not rely on these forward-looking statements as representing our views as of any date subsequent to the date of this press release.